Results 1 to 10 of about 158,569 (182)

Tumor immune microenvironment score predicts efficacy of immune checkpoint inhibitors-based regimens in advanced non-small cell lung cancer [PDF]

Journal of Translational Medicine
Background Immune checkpoint inhibitor (ICI)-based regimens have become the standard first-line treatment for advanced non-small cell lung cancer (NSCLC).
Jiacheng Dai, Huan Yan, Yangqian Chen, Yuda Zhang, Zhe Huang, Zhaohui Ruan, Fang Tian, Haoyue Qin, Qinqin Xu, Jin Wang, Xing Li, Peng Cheng, Changbin Zhu, Nong Yang, Liang Zeng, Yongchang Zhang   +15 more
doaj   +2 more sources

Scarless circular mRNA-based CAR-T cell therapy elicits superior antitumor efficacy [PDF]

Signal Transduction and Targeted Therapy
Messenger RNA (mRNA)-based transient expression of chimeric antigen receptors (CARs) results in optimal safety profiles and provides promising opportunities to address existing challenges associated with viral vector-based CAR-T-cell therapies and to ...
Qinchao Hu, Hui Zhao, Kaicheng Zhou, Xuefei Tian, Qian Wang, Xianxin Hua, Xuyao Zhang   +6 more
doaj   +2 more sources

PieParty: visualizing cells from scRNA-seq data as pie charts [PDF]

Life Science Alliance, 2021
Single-cell RNA sequencing (scRNA-seq) has been a transformative technology in many research fields. Dimensional reduction techniques such as UMAP and tSNE are used to visualize scRNA-seq data in two or three dimensions for cells to be clustered in biologically meaningful ways.
Stefan Kurtenbach, James J Dollar, Anthony M Cruz, Michael A Durante, Christina L Decatur, J William Harbour   +5 more
openaire   +3 more sources

PIE-FLIM Measurements of Two Different FRET-Based Biosensor Activities in the Same Living Cells [PDF]

Biophysical Journal, 2020
ABSTRACTWe report the use of pulsed interleaved excitation-fluorescence lifetime imaging microscopy (PIE-FLIM) to measure the activities of two different biosensor probes simultaneously in single living cells. Many genetically encoded biosensors rely on the measurement of Förster resonance energy transfer (FRET) to detect changes in biosensor ...
Reissaus, Christopher A., Day, Kathleen H., Mirmira, Raghavendra G., Dunn, Kenneth W., Pavalko, Fredrick M., Day, Richard N.   +5 more
openaire   +3 more sources

Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection

Frontiers in Immunology, 2021
Previously, we constructed a library of Ligilactobacillus salivarius strains from the intestine of wakame-fed pigs and reported a strain-dependent capacity to modulate IFN-β expression in porcine intestinal epithelial (PIE) cells.
Yuhki Indo, Yuhki Indo, Shugo Kitahara, Shugo Kitahara, Mikado Tomokiyo, Mikado Tomokiyo, Shota Araki, Md. Aminul Islam, Md. Aminul Islam, Md. Aminul Islam, Binghui Zhou, Binghui Zhou, Leonardo Albarracin, Leonardo Albarracin, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hisashi Aso, Hideki Takahashi, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Julio Villena, Haruki Kitazawa, Haruki Kitazawa   +30 more
doaj   +1 more source

Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling. [PDF]

PLoS ONE, 2016
In this work, we aimed to characterize the antiviral response of an originally established porcine intestinal epithelial cell line (PIE cells) by evaluating the molecular innate immune response to rotavirus (RVs).
Takamasa Ishizuka, Paulraj Kanmani, Hisakazu Kobayashi, Ayako Miyazaki, Junichi Soma, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Julio Villena, Haruki Kitazawa   +12 more
doaj   +1 more source

Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression. [PDF]

PLoS ONE, 2013
BACKGROUND: We previously showed that evaluation of anti-inflammatory activities of lactic acid bacteria in porcine intestinal epithelial (PIE) cells is useful for selecting potentially immunobiotic strains. OBJECTIVE: The aims of the present study were:
Yohsuke Tomosada, Julio Villena, Kozue Murata, Eriko Chiba, Tomoyuki Shimazu, Hisashi Aso, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Haruki Kitazawa   +9 more
doaj   +1 more source

PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing

Nature Communications, 2023
RNA-binding proteins (RBPs) are essential for gene regulation, but it remains a challenge to identify their RNA targets across cell types. Here we present PIE-Seq to investigate Protein-RNA Interaction with dual-deaminase Editing and Sequencing by ...
Xiangbin Ruan, Kaining Hu, Xiaochang Zhang   +2 more
doaj   +1 more source

A dendrite in every pie [PDF]

Virulence, 2012
Dendritic cells (DC) are a heterogeneous population of innate immune cells that are fundamental to initiating responses against invading pathogens and regulating immune responses. Myeloid DC (mDC) act as a bridge between the innate and adaptive immune response during virus infections but their role in immunity to human immunodeficiency virus (HIV ...
Wonderlich, Elizabeth R., Barratt-Boyes, Simon M.   +1 more
openaire   +2 more sources

Effect of Aerobic Exercise on Oxidative Stress and Inflammatory Response During Particulate Matter Exposure in Mouse Lungs

Frontiers in Physiology, 2022
Regular exercise provides several health benefits that can improve the cardiovascular and musculoskeletal systems, but clear evidence on the effect of exercise-induced hyperventilation in particulate matter (PM) exposure is still lacking.
Byunghun So, Jinhan Park, Junho Jang, Wonchung Lim, Saba Imdad, Saba Imdad, Chounghun Kang, Chounghun Kang   +7 more
doaj   +1 more source