Results 1 to 10 of about 4,923,870 (255)

PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo [PDF]

G3: Genes, Genomes, Genetics, 2018
In the C. elegans embryo, the germline lineage is established through successive asymmetric cell divisions that each generate a somatic and a germline daughter cell.
Timothy J. Gauvin, Bingjie Han, Michael J. Sun, Erik E. Griffin   +3 more
doaj   +4 more sources

Saffron-Derived Antioxidant and Passiflora incarnata L. Extract Preserve Cerebellar Fetuin-A and Protect Purkinje Cells Against MPTP/MPP⁺-Induced Injury [PDF]

Antioxidants
Oxidative stress contributes to neuronal injury in Parkinson’s disease (PD), and the cerebellum is increasingly recognized as an affected region. We previously reported that Fetuin-A (alpha-2-HS-glycoprotein) is reduced in cerebellar Purkinje cells in ...
Seohee Choi, Chae-Young Kim, Kayoung Ko, Miri Jo, Jinhye Kim, Isaac Jinwon Yi, Sang-Soep Nahm, Kiyoung Kim, Sun-Shin Yi   +8 more
doaj   +2 more sources

Dysregulation of cholesterol metabolism decreases cervical cancer cells’ migratory ability caused by propofol in vitro [PDF]

Scientific Reports
Cervical cancer is a prevalent gynecological malignancy, and surgical resection can be curative for early-stage disease. Propofol is a commonly used intravenous anesthetic during cervical cancer surgery. However, the effects of propofol on the biological
Mengyun Zhao, Pan Liu, Chen Sun, Fengling Luo, Yuguang Huang, Lijian Pei   +5 more
doaj   +2 more sources

PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing [PDF]

Nature Communications, 2023
RNA-binding proteins (RBPs) are essential for gene regulation, but it remains a challenge to identify their RNA targets across cell types. Here we present PIE-Seq to investigate Protein-RNA Interaction with dual-deaminase Editing and Sequencing by ...
Xiangbin Ruan, Kaining Hu, Xiaochang Zhang   +2 more
doaj   +2 more sources

A combined PIE-FRET and FCS assay to monitor RNA dynamics and cleavage by SARS-CoV-2 Nsp15 [PDF]

Scientific Reports
Nsp15 is an endoribonuclease, highly conserved among coronaviruses, that helps the virus evade detection in host cells by cleaving uridine-rich viral RNA sequences. Those sequences would otherwise trigger immune response pathways.
Kenya Gordon, Zoe M. Wright, Cameron R. Stephens, Meredith N. Frazier, Benjamin S. Clark, Isha M. Wilson, Irene Silvernail, Robin E. Stanley, Sharonda J. LeBlanc   +8 more
doaj   +2 more sources

Thermal Inactivation of Cells of Salmonella spp. in Pot Pies Prepared With a Beef, Chicken, or Meat Alternative Filling, With and Without Gravy, During Cooking in a Convection Oven

Journal of Food Protection
Cooking parameters elaborated in the U.S. Department of Agriculture’s Food Safety and Inspection Service Cooking Guideline for Meat and Poultry Products (Appendix A) were evaluated for inactivation of Salmonella spp. in pot pies. To prepare dough for pot
Anna C.S. Porto-Fett, Laura E. Shane, Bradley A. Shoyer, Manuela Osoria, Aaron Beczkiewicz, Kristina Barlow, Brad Webb, Bryce Merrill, Marie Hooker, Bryan T. Vinyard, John B. Luchansky   +10 more
doaj   +3 more sources

Anti-inflammatory and Antioxidant Effects of Pluchea indica Leaf Extract in TNF-α-Induced Human Endothelial Cells

Walailak Journal of Science and Technology, 2021
Pluchea indica is a shrub plant found in mangrove forests. The leaves are consumed as food and herbal tea and exhibit various biological effects, such as antioxidant and anti-inflammatory activities, in macrophages and animal models.
Klaokwan SRISOOK, Suthasinee JINDA, Ekaruth SRISOOK   +2 more
doaj   +3 more sources

Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection

Frontiers in Immunology, 2021
Previously, we constructed a library of Ligilactobacillus salivarius strains from the intestine of wakame-fed pigs and reported a strain-dependent capacity to modulate IFN-β expression in porcine intestinal epithelial (PIE) cells.
Yuhki Indo, Yuhki Indo, Shugo Kitahara, Shugo Kitahara, Mikado Tomokiyo, Mikado Tomokiyo, Shota Araki, Md. Aminul Islam, Md. Aminul Islam, Md. Aminul Islam, Binghui Zhou, Binghui Zhou, Leonardo Albarracin, Leonardo Albarracin, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hisashi Aso, Hideki Takahashi, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Julio Villena, Haruki Kitazawa, Haruki Kitazawa   +30 more
doaj   +1 more source

Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling. [PDF]

PLoS ONE, 2016
In this work, we aimed to characterize the antiviral response of an originally established porcine intestinal epithelial cell line (PIE cells) by evaluating the molecular innate immune response to rotavirus (RVs).
Takamasa Ishizuka, Paulraj Kanmani, Hisakazu Kobayashi, Ayako Miyazaki, Junichi Soma, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Julio Villena, Haruki Kitazawa   +12 more
doaj   +1 more source

Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression. [PDF]

PLoS ONE, 2013
BACKGROUND: We previously showed that evaluation of anti-inflammatory activities of lactic acid bacteria in porcine intestinal epithelial (PIE) cells is useful for selecting potentially immunobiotic strains. OBJECTIVE: The aims of the present study were:
Yohsuke Tomosada, Julio Villena, Kozue Murata, Eriko Chiba, Tomoyuki Shimazu, Hisashi Aso, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Haruki Kitazawa   +9 more
doaj   +1 more source