Results 101 to 110 of about 10,899,927 (248)
Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome
Advanced Science, EarlyView.This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang +11 morewiley +1 more sourceCsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis
Advanced Science, EarlyView.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin +14 morewiley +1 more sourceMultiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma
Hepatology, EarlyView., 2022 Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims
Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara +29 morewiley +1 more sourceExpression of cytokines in porcine intestinal epithelial (PIE) cells after stimulation with heat-stable Enterotoxigenic Escherichia coli (ETEC) pathogen-associated molecular patterns (PAMPs).
, 2013 Tomosada Yohsuke, Villena Julio, M. Kozue, Chiba Eriko, Shimazu Tomoyuki, Aso Hisashi, Iwabuchi Noriyuki, Xiao Jin-zhong, Saito Tadao, Kitazawa Haruki +9 moresemanticscholar +1 more sourcePseudocapacitance-boosted ultrafast Na storage in a pie-like FeS@C nanohybrid as an advanced anode material for sodium-ion full batteries.
Nanoscale, 2018 Bao‐Hua Hou, Ying‐Ying Wang, Jin-Zhi Guo, Qiu‐Li Ning, Xiao-tong Xi, Wei-Lin Pang, A. Cao, Xinlong Wang, Jingping Zhang, Xing-long Wu +9 moresemanticscholar +1 more sourcePro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors
Advanced Science, EarlyView.Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao +11 morewiley +1 more sourceEssential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària +12 morewiley +1 more sourceTrasplante de células madre autólogas en el miembro inferior isquémico de un paciente con arteriosclerosis obliterante crítica Transplant of autologous stem cells in the ischemic lower limb of a patient with severe arteriosclerosis obliterans
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2005 Se presenta el caso de un paciente masculino de 72 años, que fue hospitalizado por dolor de reposo intenso en la extremidad inferior derecha y necrosis isquémica del tercer y cuarto dedos del pie con tendencia a extenderse al quinto dedo y al dorso del ...Porfirio Hernández Ramírez, Elvira Dorticós Balea, Carlos Hernández Padrón, Lázaro Cortina Rosales, Vianed Marsán Suárez, Consuelo Macías Abraham, Miriam Sánchez Segur, José M Ballester Santovenia, Lázaro O del Valle Pérez, Natalia Pol Marrón, Pedro Goicochea Díaz, Ángela Blanco Díaz, Dinorah González Viñales, Heriberto Artaza Sanz, Alberto Martínez Sardiñas, Francisco Díaz Ramírez +15 moredoaj
