Results 31 to 40 of about 10,899,927 (248)

Lactiplantibacillus plantarum Strains Modulate Intestinal Innate Immune Response and Increase Resistance to Enterotoxigenic Escherichia coli Infection

Microorganisms, 2022
Currently, probiotic bacteria with not transferable antibiotic resistance represent a sustainable strategy for the treatment and prevention of enterotoxigenic Escherichia coli (ETEC) in farm animals.
Ayelen Baillo, Julio Villena, Leonardo Albarracín, Mikado Tomokiyo, Mariano Elean, Kohtaro Fukuyama, Sandra Quilodrán-Vega, Silvina Fadda, Haruki Kitazawa   +8 more
doaj   +1 more source

Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes

Frontiers in Immunology, 2020
Previously, we evaluated the effect of the immunobiotic strain Lactobacillus rhamnosus CRL1505 on the transcriptomic response of porcine intestinal epithelial (PIE) cells triggered by the challenge with the Toll-like receptor 3 (TLR-3) agonist poly(I:C ...
Leonardo Albarracin, Leonardo Albarracin, Valeria Garcia-Castillo, Valeria Garcia-Castillo, Yuki Masumizu, Yuhki Indo, Md Aminul Islam, Yoshihito Suda, Apolinaria Garcia-Cancino, Hisashi Aso, Hisashi Aso, Hideki Takahashi, Hideki Takahashi, Haruki Kitazawa, Haruki Kitazawa, Julio Villena, Julio Villena   +16 more
doaj   +1 more source

Characterising hyperinsulinaemia induced insulin resistance in human skeletal muscle cells.

Journal of Molecular Endocrinology, 2020
Hyperinsulinemia potentially contributes to insulin resistance in metabolic tissues, such as skeletal muscle. The purpose of these experiments was to characterise glucose uptake, insulin signalling and relevant gene expression in primary human skeletal ...
M. C. Turner, N. R. Martin, D. Player, R. Ferguson, P. Wheeler, C. Green, E. Akam, M. Lewis   +7 more
semanticscholar   +1 more source

Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis by Differentially Modulating the Transcriptomic Response of Intestinal Epithelial Cells

Frontiers in Immunology, 2020
Immunobiotics have emerged as a promising intervention to alleviate intestinal damage in inflammatory bowel disease (IBD). However, the beneficial properties of immunobiotics are strain dependent and, therefore, each strain has to be evaluated in order ...
Nana Sato, Nana Sato, Valeria Garcia-Castillo, Valeria Garcia-Castillo, Mao Yuzawa, Mao Yuzawa, Md. Aminul Islam, Md. Aminul Islam, Md. Aminul Islam, Leonardo Albarracin, Leonardo Albarracin, Leonardo Albarracin, Mikado Tomokiyo, Mikado Tomokiyo, Wakako Ikeda-Ohtsubo, Wakako Ikeda-Ohtsubo, Apolinaria Garcia-Cancino, Hideki Takahashi, Hideki Takahashi, Julio Villena, Julio Villena, Haruki Kitazawa, Haruki Kitazawa   +22 more
doaj   +1 more source

Transcriptomic Analysis of the Innate Antiviral Immune Response in Porcine Intestinal Epithelial Cells: Influence of Immunobiotic Lactobacilli

Frontiers in Immunology, 2017
Lactobacillus rhamnosus CRL1505 and Lactobacillus plantarum CRL1506 are immunobiotic strains able to increase protection against viral intestinal infections as demonstrated in animal models and humans.
L. Albarracín, Hisakazu Kobayashi, Hikaru Iida, Nana Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa, J. Villena   +9 more
semanticscholar   +1 more source

Evaluating cellular polyfunctionality with a novel polyfunctionality index. [PDF]

PLoS ONE, 2012
Functional evaluation of naturally occurring or vaccination-induced T cell responses in mice, men and monkeys has in recent years advanced from single-parameter (e.g. IFN-γ-secretion) to much more complex multidimensional measurements.
Martin Larsen, Delphine Sauce, Laurent Arnaud, Solène Fastenackels, Victor Appay, Guy Gorochov   +5 more
doaj   +1 more source

Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol

BMJ Open, 2015
Introduction Pre-eclampsia is a major complication of pregnancy, globally responsible for 60 000 maternal deaths per year, and far greater numbers of fetal losses. There is no definitive treatment other than delivery.
C. Cluver, S. Walker, B. Mol, G. Theron, D. Hall, R. Hiscock, N. Hannan, S. Tong   +7 more
semanticscholar   +1 more source

Connecting PIE-FCCS Measurements to Dimerization Affinity to Resolve the Role of GPCR Dimerization in Live Cells [PDF]

Biophysical Journal, 2016
Since the rhodopsin crystal structure was reported over 15 years ago, the structure and dynamics of class A G-protein coupled receptors (GPCR) have been a growing area of investigation. A significant body of research has shown the existence of GPCR dimers and possibly higher order oligomers in native tissue.
openaire   +1 more source

Genetic Association of the Porcine C9 Complement Component with Hemolytic Complement Activity [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
The complement system is a part of the natural immune regulation mechanism against invading pathogens. Complement activation from three different pathways (classical, lectin, and alternative) leads to the formation of C5-convertase, an enzyme for ...
D. V. A. Khoa, K. Wimmers
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source