Results 141 to 150 of about 11,131 (244)

Cellular response to short-time mechanical stimuli: mediating Ca2+ influx via PIEZO1

European Cells & Materials
Physical activity shows a positive correlation with overall health, and vigorous intermittent lifestyle physical activity (VILPA) similarly offers advantages in reducing the risk of all-cause mortality.
Fuan Wang, Hongkun Chen, Zhongyuan He, Jianfeng Li, Zhengya Zhu, Tao Tang, Junhong Li, Jiaxiang Zhou, Qiuxiao Tan, Zhen Li, Martin J. Stoddart, Xizhe Liu, Manman Gao, Zhiyu Zhou, Shaoyu Liu   +14 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway

Bone Research
Piezo1, a key mechanosensor in bone homeostasis, plays a crucial role in fracture healing. However, the mechanisms through which Piezo1 regulates chondrocytes and affects endochondral ossification remain poorly understood. This study aimed to investigate
Tao Zhang, Hongzhi Lv, Siming Jia, Lijun Wang, Weijian Liu, Kai Ding, Xiaofeng Du, Guangzhao Hou, Zhiyong Hou, Yingze Zhang, Weiguo Zou, Wei Chen, Yanbin Zhu   +12 more
doaj   +1 more source

Piezo1-related physiological and pathological processes in glioblastoma

Frontiers in Cell and Developmental Biology
IntroductionGlioblastoma (GBM) is the most malignant of the astrocytomas, primarily involving the cerebral hemispheres and cerebral cortex. It is one of the fatal refractory solid tumors with a 5-year survival rate of only 5% in adults.
Weijia Fu, Weijia Fu, Weijia Fu, Xue Hou, Xue Hou, Xue Hou, Lijuan Ding, Lijuan Ding, Lijuan Ding, Jiaying Wei, Jiaying Wei, Jiaying Wei, Wei Hou, Wei Hou, Wei Hou   +14 more
doaj   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Emerging S100A11 roles: Regulation of focal adhesion dynamics and mechanosensing

Cell Structure and Function
S100A11 is a small calcium-binding protein that has been studied in the context of growth regulation and membrane repair. However, it has recently been linked to the disassembly of focal adhesions.
Tareg Omer Mohammed, Mahmoud I. Shoulkamy, Djamel Eddine Chafai   +2 more
doaj   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients

Cancer Management and Research, 2020
Shanqiang Qu,1,* Shuting Li,2,* Zhicheng Hu3 1Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China; 2Department of Plastic Surgery, The First Affiliated Hospital, Sun Yat ...
Qu S, Li S, Hu Z
doaj  

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, Volume 6, Issue 3, March 2026.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source