Frontiers in Cell and Developmental Biology, 2022 A mechanosensitive ion channel, Piezo1 induces non-selective cation flux in response to various mechanical stresses. However, the biological interpretation and underlying mechanisms of cells resulting from Piezo1 activation remain elusive.
Heon-Su Kim +15 more
doaj +1 more source
Human phenotypes caused by PIEZO1 mutations; one gene, two overlapping phenotypes? [PDF]
, 2018 PIEZO1 is a large mechanosensitive ion channel protein. Diseases associated with PIEZO1 include autosomal recessive Generalised Lymphatic Dysplasia of Fotiou (GLDF) and autosomal dominant Dehydrated Hereditary Stomatocytosis with or without ...
Albuisson +30 more
core +1 more source
On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels [PDF]
, 2017 In a healthy adult, the transport of O2 and CO2 between lungs and tissues is performed by about 2 · 1013 red blood cells, of which around 1.7 · 1011 are renewed every day, a turnover resulting from an average circulatory lifespan of about 120 days ...
Lew, VL, Tiffert, JT
core +1 more source
Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton [PDF]
, 2015 The invasive blood-stage malaria parasite - the merozoite - induces rapid morphological changes to the target erythrocyte during entry. However, evidence for active molecular changes in the host cell that accompany merozoite invasion is lacking. Here, we
Angrisano, Fiona +6 more
core +5 more sources
Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line [PDF]
, 2017 The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function. We sought to investigate the expression and functional relevance of MS channels in human platelets.
Agboh +72 more
core +1 more source
Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis
Channels, 2022 Ovarian cancer (OC) is a highly malignant cancer with great metastatic potential. Here we aimed to investigate the role of Piezo1, a gene related to the mechanical environment of the tumor, in promoting the metastasis of OC. We performed Piezo1 knockdown
Yanjie Xiong +9 more
doaj +1 more source
The changing landscape of membrane protein structural biology through developments in electron microscopy [PDF]
, 2016 Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts.
Albuisson J +7 more
core +1 more source
Single-particle tracking reveals heterogeneous PIEZO1 diffusion
Biophysical Journal, 2022 ABSTRACTThe mechanically-activated ion channel PIEZO1 is critical to numerous physiological processes, and is activated by diverse mechanical cues. The channel is gated by membrane tension and has been found to be mobile in the plasma membrane. We employed single particle tracking (SPT) of endogenous, tdTomato-tagged PIEZO1 using Total Internal ...
Alan T. Ly +6 more
openaire +2 more sources
Osteoarthritis year in review 2015: mechanics [PDF]
, 2015 Motivated by the conceptual framework of multi-scale biomechanics, this narrative review highlights recent major advances with a focus on gait and joint kinematics, then tissue-level mechanics, cell mechanics and mechanotransduction, matrix mechanics ...
Grodzinsky, Alan J, Varady, Nathan H.
core +1 more source
Piezo1 opposes age‐associated cortical bone loss
Aging Cell, 2023 AbstractAs we age, our bones undergo a process of loss, often accompanied by muscle weakness and reduced physical activity. This is exacerbated by decreased responsiveness to mechanical stimulation in aged skeleton, leading to the hypothesis that decreased mechanical stimulation plays an important role in age‐related bone loss.
Xuehua Li +8 more
openaire +2 more sources