Results 41 to 50 of about 11,131 (244)

Tmc1 point mutation affects Ca2+ sensitivity and block by dihydrostreptomycin of the mechanoelectrical transducer current of mouse outer hair cells [PDF]

, 2016
The transduction of sound into electrical signals depends on mechanically sensitive ion channels in the stereociliary bundle. The molecular composition of this mechanoelectrical transducer (MET) channel is not yet known.
Corns, Laura F, Johnson, Stuart L, Kros, Corne J, Marcotti, Walter   +3 more
core   +3 more sources

Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

eLife, 2021
How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni, Jonathan Marquez, Priya Date, Rosa Ventrella, Brian J Mitchell, Mustafa K Khokha   +5 more
doaj   +1 more source

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1 [PDF]

, 2017
Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human ...
A Rosenhouse-Dantsker, AA Caro, AE Dubin, AF Seasholtz, AK Amin, AR Amin, C Asker, C Iavazzo, C Zhu, CAM Huser, CE Combs, CR Chu, DA Lovejoy, DA Lovejoy, DK Grammatopoulos, DP Behan, E Gonzalez-Rey, EW Hillhouse, F Finger, FJ Blanco, H Muir., H Xu, H Zhao, HI Roach, I Borbiro, J Tao, J Tao, J Tao., J Vaughen, J Wu, JB Calixto, JP Urban, KM Lawrence, KM Lawrence, KM Lawrence, L Fedrizzi, L Leistad, L Volkers, M Kohno, M Sisignano, M Uzuki, MB Goldring, MH Perrin, MR Servin-Vences, N Yatugi, NY Intekhab-Alam, PP Srinivasan, R Barrett-Jolley, R Lewis, R Lewis, RF Loeser, S Hashimoto, SA Gudipaty, SN Bagriantsev, SY Hsu, T Blank, T Smani, TT Chowdhury, W Lee, WA Pedersen, WA Pedersen, XF Li, Y Huang   +62 more
core   +1 more source

Pharmacology of PIEZO1 channels

British Journal of Pharmacology
AbstractPIEZO1 is a eukaryotic membrane protein that assembles as trimers to form calcium‐permeable, non‐selective cation channels with exquisite capabilities for mechanical force sensing and transduction of force into effect in diverse cell types that include blood cells, endothelial cells, epithelial cells, fibroblasts and stem cells and diverse ...
Jacob A. Kinsella, Marjolaine Debant, Gregory Parsonage, Lara C. Morley, Muath Bajarwan, Charlotte Revill, Richard Foster, David J. Beech   +7 more
openaire   +3 more sources

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

Cell Death and Disease, 2021
Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes.
Jiahao He, Bin Fang, Shengzhou Shan, Yun Xie, Chuandong Wang, Yifan Zhang, Xiaoling Zhang, Qingfeng Li   +7 more
doaj   +1 more source

Cellular Mechanosensitivity: Validation of an Adaptable 3D-Printed Device for Microindentation

Nanomaterials, 2022
Mechanotransduction refers to the cellular ability to sense mechanical stimuli from the surrounding environment and convert them into biochemical signals that regulate cellular physiology and homeostasis.
Giulio Capponi, Martina Zambito, Igor Neri, Francesco Cottone, Maurizio Mattarelli, Massimo Vassalli, Silvia Caponi, Tullio Florio   +7 more
doaj   +1 more source

Heterologous Expression of the Piezo1-ASIC1 Chimera Induces Mechanosensitive Currents with Properties Distinct from Piezo1 [PDF]

Neuron, 2017
Piezo1 represents a prototype of the mammalian mechanosensitive cation channel, but its molecular mechanism remains elusive. In a recent study, we showed that C-terminal region, which contains the last two TMs, of 2189-2547 of Piezo1 forms the bona fide pore module, and systematically identified the pore-lining helix and key pore-property-determining ...
Qiancheng, Zhao, Kun, Wu, Shaopeng, Chi, Jie, Geng, Bailong, Xiao   +4 more
openaire   +2 more sources

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

3D Microfluidic Bone Tumor Microenvironment Comprised of Hydroxyapatite/Fibrin Composite [PDF]

, 2019
Bone is one of the most common sites of cancer metastasis, as its fertile microenvironment attracts tumor cells. The unique mechanical properties of bone extracellular matrix (ECM), mainly composed of hydroxyapatite (HA) affect a number of cellular ...
Abbasi Aval, Ahn, Ahn, Ahn, Ahn, Alépée, Baek, Bersini, Bielenberg, Camps, Chen, Chung, Coleman, Coste, Dey, Du, Ducy, Friedrich, Gill, Han, Hanawa, Hung, Hytönen, Jacob, Jusoh, Kammori, Karnoub, Katoh, Katt, Kim, Kloss, Lai, LaValley, Li, Li, Lin, Liu, Ma, Mancini, Meena, Mehta, Michor, Mueller-Klieser, Noori, Oh, Pardo-Pastor, Pathi, Pathi, Pietras, Pilmane, Ramaswamy, Rao, Rao, Ribeiro, Rodrigues, Sei, Shamloo, Shi, Sundermeyer, von Tell, Wang, Weis, Yamaguchi, Yin, Yoneda, Yoshikawa, Zhang, Zhu, Zhu   +68 more
core   +2 more sources

Piezo1 activation gains traction

The FASEB Journal, 2020
A major unanswered question in biology is how mechanical forces are generated, detected and transduced by cells to impact biochemical and genetic programs. Our work is aimed at uncovering the mechanical principles at play in cells and tissues using novel molecular, imaging and bioengineering tools.
openaire   +1 more source