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The retinal pigment epithelium as a gateway for monocyte trafficking into the eye [PDF]
The EMBO Journal, 2016 The choroid plexus epithelium within the brain ventricles orchestrates blood-derived monocyte entry to the central nervous system under injurious conditions, including when the primary injury site is remote from the brain. Here, we hypothesized that the retinal pigment epithelium (RPE) serves a parallel role, as a gateway for monocyte trafficking to ...
Inbal Benhar +3 more
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Setting Eyes on the Retinal Pigment Epithelium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The neural component of the zebrafish eye derives from a small group of cells known as the eye/retinal field. These cells, positioned in the anterior neural plate, rearrange extensively and generate the optic vesicles (OVs). Each vesicle subsequently folds over itself to form the double-layered optic cup, from which the mature eye derives.
Tania Moreno-Marmol +4 more
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The retinal pigment epithelium of the eye regulates the development of scleral cartilage
Developmental Biology, 2010 The majority of vertebrate species have a layer of hyaline cartilage within the fibrous sclera giving an extra degree of support to the eyeball. In chicks, this is seen as a cuplike structure throughout the scleral layer. However, the mechanisms that control the development of scleral cartilage are largely unknown.
Thompson, H +3 more
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Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium [PDF]
Journal of Visualized Experiments, 2011 The retinal pigment epithelium (RPE) lies at the back of the mammalian eye, just under the neural retina, which contains the photoreceptors (rods and cones). The RPE is a monolayer of pigmented cuboidal cells and associates closely with the neural retina just above it.
Alexander J.R. Bishop, Alison B. Claybon
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The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye [PDF]
Pigment Cell Research, 2006 SummaryVertebrate retinal pigment epithelium (RPE) cells are derived from the multipotent optic neuroepithelium, develop in close proximity to the retina, and are indispensible for eye organogenesis and vision. Recent advances in our understanding of RPE development provide evidence for how critical signaling factors operating in dorso‐ventral and ...
Heinz Arnheiter +4 more
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chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis
Developmental Biology, 2005 Despite the importance of the retinal pigment epithelium (RPE) for vision, the molecular processes involved in its specification are poorly understood. We identified two new mutant alleles for the zebrafish gene chokh (chk), which display a reduction or absence of the RPE.
Agustin Rojas-Muñoz +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Retinal degenerative diseases affect specific regions of the retinal pigment epithelium (RPE), suggesting the presence of functionally different RPE subpopulations.
D. Ortolan +9 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The chromosome 10q26 locus is the genetic region most strongly associated with elevated risk of age-related macular degeneration (AMD), but the underlying genetic defects initiating disease are unresolved. Using human-derived eye tissues, we
B. Williams +15 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Background: The aim of this study was to test the feasibility and safety of subretinal transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) cells into the healthy margins and within areas of degenerative
A. Duarri +15 more
semanticscholar +1 more source
Photodynamic Therapy Treatment for Eyes with Drusenoid Pigment Epithelium Detachment [PDF]
Korean Journal of Ophthalmology, 2008 We report the clinical course of photodynamic therapy (PDT) in a patient with drusenoid pigment epithelium detachment (PED). A patient with drusenoid PED underwent PDT follow-up was carried out at one week, one month, three months, six months and one year after treatment.
Ki Seok Kim, Na Young Lee
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