Results 11 to 20 of about 77,821 (282)

Early stages of retinal development depend on Sec13 function [PDF]

, 2013
Summary ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Cavodeassi, Florencia, Feng, Yi, Schmidt, Katy, Stephens, David J   +3 more
core   +3 more sources

Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]

, 2012
The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Aisenbrey, Alcazar, Alge, Bhutto, Bodaghi, Burke, Campochiaro, Christoph Szober, Chu, Claudia Alge-Priglinger, Clegg, Cornelia Deeg, Deeg, Deeg, Deeg, Deeg, Deeg, Degroote, Doherty, Dunn, Eberhardt, Ehrenhofer, Greer, Gullapalli, Gundersen, Ham, Hamel, Hauck, Hauck, Hauck, Hauck, Ho, Huang, Karl, Kerstin Euler, Kristina Fröhlich, Li, Limb, Machemer, Marius Ueffing, McBee, Milyushina, Mochizuki, Muramatsu, Nagai, Parker, Philp, Rizzolo, Rotilio, Singer, Stefanie Hauck, Strauss, Vacanti, Wolf, Wu   +54 more
core   +3 more sources

Methods for culturing retinal pigment epithelial cells: a review of current protocols and future recommendations

Journal of Tissue Engineering, 2016
The retinal pigment epithelium is an important part of the vertebrate eye, particularly in studying the causes and possible treatment of age-related macular degeneration.
Aaron H Fronk, Elizabeth Vargis
doaj   +1 more source

Near-infrared fundus autoflorescence imaging in solar retinopathy

GMS Ophthalmology Cases, 2017
Solar retinopathy is a rare clinical entity caused by photochemical damage to the retinal pigment epithelium layer and photoreceptors of the fovea. Here we describe a case of a 33-year-old female patient diagnosed by near-infrared fundus autofluorescence
Czepita, Maciej, Machalińska, Anna, Czepita, Damian   +2 more
doaj   +1 more source

Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium

Cell Reports, 2020
Summary: When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye.
Celia M. Bisbach, Daniel T. Hass, Brian M. Robbings, Austin M. Rountree, Martin Sadilek, Ian R. Sweet, James B. Hurley   +6 more
doaj   +1 more source

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

eLife, 2017
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors ...
Mark A Kanow, Michelle M Giarmarco, Connor SR Jankowski, Kristine Tsantilas, Abbi L Engel, Jianhai Du, Jonathan D Linton, Christopher C Farnsworth, Stephanie R Sloat, Austin Rountree, Ian R Sweet, Ken J Lindsay, Edward D Parker, Susan E Brockerhoff, Martin Sadilek, Jennifer R Chao, James B Hurley   +16 more
doaj   +1 more source

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. [PDF]

, 2014
Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Al-Ubaidi, Muayyad, Cheng, Guo, Deng, Jun, Kassai, Miki, Kawaguchi, Riki, Sun, Hui, Ter-Stepanian, Mariam, Zhong, Ming   +7 more
core   +1 more source

Structure and function of the retinal pigment epithelium, photoreceptors and cornea in the eye of Sardinella aurita (Clupeidae, Teleostei)

Journal of Basic and Applied Zoology, 2016
The structure of the pigment epithelium, photoreceptors and the cornea in the eye of a teleost, Sardinella aurita was examined by light and electron microscopy.
Mostafa Ali Salem
doaj   +1 more source

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration

Cell Reports, 2020
Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss. To better understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we present a comprehensive database of human retina and retinal pigment ...
Luz D. Orozco, Hsu-Hsin Chen, Christian Cox, Kenneth J. Katschke, Jr., Rommel Arceo, Carmina Espiritu, Patrick Caplazi, Sarajane Saturnio Nghiem, Ying-Jiun Chen, Zora Modrusan, Amy Dressen, Leonard D. Goldstein, Christine Clarke, Tushar Bhangale, Brian Yaspan, Marion Jeanne, Michael J. Townsend, Menno van Lookeren Campagne, Jason A. Hackney   +18 more
doaj   +1 more source

Serpentine retinal pigment epithelial tear

Taiwan Journal of Ophthalmology, 2021
We report a case of retinal pigment epithelial tear in a patient with peripheral exudative hemorrhagic chorioretinopathy (PEHCR). A 60-year-old diabetic female presented with left eye metamorphopsia. Fundus examination showed bilateral peripheral retinal
Aditya Maitray, Piyush Kohli, Naresh Babu   +2 more
doaj   +1 more source