eLife, 2017 Here we report multiple lines of evidence for a comprehensive model for retinal energy metabolism. Metabolic flux, locations of key enzymes and our finding that glucose enters the neural retina almost entirely through photoreceptors support a ...
Mark A. Kanow +16 more
semanticscholar +5 more sources
Dual roles of the retinal pigment epithelium and lens in cavefish eye degeneration [PDF]
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2019 AbstractAstyanax mexicanus consists of two forms, a sighted surface dwelling form (surface fish) and a blind cave‐dwelling form (cavefish). Embryonic eyes are initially formed in cavefish but they are subsequently arrested in growth and degenerate during larval development.
Li Ma +4 more
openaire +6 more sources
Malignancy of eye melanomas originating in the retinal pigment epithelium of transgenic mice after genetic ablation of choroidal melanocytes. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1992 Eye tumors of the retinal pigment epithelium (RPE) have been thought generally to be benign, whereas choroidal ones are malignant. To test this assumption in mice, the W/Wv (Kit) mutant genotype was introduced into melanoma-prone transgenic mice whose ...
B. Mintz, Andres J Klein-Szanto
semanticscholar +2 more sources
Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium
Cell Reports, 2020 When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives within a hypoxic niche in the eye.
Celia M. Bisbach +6 more
semanticscholar +3 more sources
Disk shedding in the absence of a pigment epithelium in the lizard parietal eye
Vision Research, 1993 The photoreceptors and pigment epithelia of vertebrate retinas rhythmically synthesize and degrade photosensitive membrane, but the origin of the signal to shed the outer segment tips remains unknown. The parietal eye of lizards contains cone-like photoreceptors but no pigment epithelium.
Ahmed, Jameel, Engbretson, G.
openaire +5 more sources
Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease [PDF]
Diabetes, 2001 Retinal neovascularization characterizes proliferative diabetic retinopathy (PDR). Pigment epithelium-derived factor (PEDF) has been shown to be a major antiangiogenic growth factor in the mammalian eye. PEDF expression is suppressed by hypoxia, and changes in PEDF have been correlated to the development of retinal neovascularization in animal models ...
Vincent J. Cristofalo +10 more
openaire +5 more sources
Comparison of retinal pigment epithelium cell preparations from the bovine eye [PDF]
Experientia, 1990 Retinal pigment epithelium (RPE) cells were collected from bovine eyes using a new method. The cells were harvested by vortexing the RPE and underlying choroid in 0.05 M citrate phosphate buffer, pH 5. RPE cells recovered by this method were compared to a standard method by microscopic examination of cell integrity, estimation of total protein, and ...
D. Malsbury +2 more
openaire +4 more sources
Journal of Basic and Applied Zoology, 2016 The structure of the pigment epithelium, photoreceptors and the cornea in the eye of a teleost, Sardinella aurita was examined by light and electron microscopy.
Mostafa Ali Salem
doaj +2 more sources
Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases. [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2016 Clinical-grade manufacturing of a functional retinal pigment epithelium (RPE) monolayer requires reproducing, as closely as possible, the natural environment in which RPE grows.
Nathan A Hotaling +8 more
semanticscholar +2 more sources
Pigment Epithelium-Derived Factor (PEDF) Peptide Eye Drops Reduce Inflammation, Cell Death and Vascular Leakage in Diabetic Retinopathy in Ins2Akita Mice [PDF]
Molecular Medicine, 2012 Inflammation, neurodegeneration and microvascular irregularities are included in the spectrum of defects associated with diabetic retinopathy. Here, we evaluated intraocular deliverability features of two pigment epithelium-derived factor (PEDF ...
Yanling Liu +5 more
semanticscholar +2 more sources