Results 61 to 70 of about 77,765 (343)

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]

, 2015
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja, Esteve-Rudd, Julian, Jiang, Mei, Lillo, Concepción, Lopes, Vanda S, Rump, Agrani, Williams, David S   +6 more
core   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Disease Models & Mechanisms, 2018
Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula.
Hernán H. Dieguez, Horacio E. Romeo, María F. González Fleitas, Marcos L. Aranda, Georgia A. Milne, Ruth E. Rosenstein, Damián Dorfman   +6 more
doaj   +1 more source

A latitudinal cline in the efficacy of endogenous signals: evidence derived from retinal cone contraction in fish. [PDF]

, 2011
Like many physiological systems synchronised to the light:dark cycle, retinomotor movements in 'lower' vertebrates are controlled by both the ambient illumination and input from endogenous circadian oscillators.
Allemand, Allemand, Arey, Besharse, Burnside, Burnside, Burnside, Cahill, Cahill, Costa, Dearry, Douglas, Douglas, Douglas, Douglas, Easter, Foster, Foster, Foster, Goldman, Green, Gwinner, Hastings, Hau, Iigo, Iuvone, John, John, John, John, Johnsen, Joshi, Joshi, Keny, Kirsch, Konings, Kullander, Kyriacou, Lamb, Lankinen, Lankinen, Levinson, Lofts, Lu, Lythgoe, Mayer, McCormack, McCormack, McCormack, McFarland, Menger, Michael, Olla, Perlman, Pflüger, Pittendirgh, Pittendrigh, Ribelayga, Satralkar, Satralkar, Sawyer, Shand, Simunovic, Tosini, Tosini, Wagner, Weeks, Weitzman, Welsh, Whitmore, Wigger, Yeates-Burghart   +71 more
core   +1 more source

Dexamethasone Increases Pigment Epithelium-Derived Factor in Perfused Human Eyes [PDF]

Current Eye Research, 2008
To investigate the effects of dexamethasone (DEX) on pigment epithelium-derived factor (PEDF) cDNA and secreted protein in human trabecular meshwork (TM).
Elizabeth M, Perruccio, Laura Leigh S, Rowlette, Nuria, Comes, Silvia, Locatelli-Hoops, Luigi, Notari, S Patricia, Becerra, Teresa, Borrás   +6 more
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Giant retinal pigment epithelium tears with membranous nephropathy: a case report and literature review

BMC Ophthalmology
Background Kidney and eye diseases may be closely linked. Tears of the retinal pigment epithelium (RPE) have been reported to be related to kidney diseases, such as IgA nephropathy and light-chain deposition disease.
Rui Dou, Yanhua Chu, Quanhong Han, Wei Zhang, Xue Bi   +4 more
doaj   +1 more source

Comparative evaluation of melanin content in melanosomes and melanolipofuscin granules from the human retinal pigment epithelium cells

Офтальмохирургия, 2018
Purpose. Comparative study of the melanin content in melanosomes and melanolipofuscin granules from cells of the retinal pigment epithelium of the human eye. Material and methods.
N. L. Sakina, A. E. Dontsov, E. N. Degtyarev, A. L. Kovarsky, P. M. Arbukhanova, S. A. Borzenok, M. A. Ostrovsky   +6 more
doaj   +1 more source

The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration.

PLoS ONE, 2020
ObjectiveToxic metals are suspected to play a role in the pathogenesis of age-related macular degeneration. However, difficulties in detecting the presence of multiple toxic metals within the intact human retina, and in separating primary metal toxicity ...
Roger Pamphlett, Svetlana Cherepanoff, Lay Khoon Too, Stephen Kum Jew, Philip A Doble, David P Bishop   +5 more
doaj   +1 more source

Excipient Emulsion–Based Delivery Systems for Enhancing Carotenoid Bioavailability: Advances in Formulation and Gastrointestinal Fate

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Excipient emulsion systems improve carotenoid solubilization, protect against degradation, and enhance gastrointestinal absorption through optimized formulation and digestion behavior. ABSTRACT Carotenoids are bioactive compounds that contribute to human health through antioxidant, provitamin A, and disease‐preventive effects.
Tugce Ceyhan, Elifsu Nemli, Esra Capanoglu, Merve Tomas   +3 more
wiley   +1 more source