Results 61 to 70 of about 50,998 (262)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery

Molecular Therapy: Nucleic Acids, 2017
Pigment epithelium derived factor (PEDF) is a potent antiangiogenic, neurotrophic, and neuroprotective molecule that is the endogenous inhibitor of vascular endothelial growth factor (VEGF) in the retina.
Laura Garcia-Garcia, Sergio Recalde, Maria Hernandez, Jaione Bezunartea, Juan Roberto Rodriguez-Madoz, Sandra Johnen, Sabine Diarra, Corinne Marie, Zsuzsanna Izsvák, Zoltán Ivics, Daniel Scherman, Martina Kropp, Gabriele Thumann, Felipe Prosper, Patricia Fernandez-Robredo, Alfredo Garcia-Layana   +15 more
doaj   +1 more source

Near-infrared transillumination imaging combined with aperture photometry for the quantification of melanin in the iris pigment epithelium.

PLoS ONE, 2020
Near-infrared transillumination is used in the diagnosis and the management of different eye diseases. In particular, it enables the visualization of melanin in the pigment epithelium of the iris.
Maciej Czepita
doaj   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Idiopathic pigmented vitreous cyst without autofluorescence: a case report

BMC Ophthalmology, 2017
Background Vitreous cysts are rare clinical findings and seldom cause visual disturbance. They are generally classified as congenital or acquired and are considered idiopathic when the etiology can not be determined.
Jing Lu, Yan Luo, Lin Lu
doaj   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Identification of Pigment Epithelium-Derived Factor in the Interphotoreceptor Matrix of Bovine Eyes

Protein Expression and Purification, 1995
Pigment epithelium-derived factor (PEDF) is a neurotrophic protein and a member of the serine protease inhibitor superfamily. Here we describe the identification of PEDF in bovine eyes and optimization of its purification from this natural source.
Y Q, Wu, V, Notario, G J, Chader, S P, Becerra   +3 more
openaire   +2 more sources

Understanding the spacing of placodes in the eye: A comparative study across age and species

The Anatomical Record, EarlyView.
Abstract The conjunctival placodes of the avian eye form in an intriguing and conserved sequence in a circular annulus around the cornea. These 13–16 placodes develop into papillae that are essential for inducing underlying intramembranous flat bones, known as scleral ossicles, which form an important part of the ocular skeleton.
Florence Joseph, Tamara A. Franz‐Odendaal   +1 more
wiley   +1 more source

Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV

GMS Ophthalmology Cases, 2020
Objective: To report on the survival of a retinal pigment epithelium (RPE)-choroid graft translocated to treat a patient with drusenoid pigment epithelial detachment (DPED).Methods: We describe a patient with bilateral high-risk DPED where one eye was ...
Sillen, Hedwig, Ruys, Joke, Schauwvlieghe, Pieter-Paul, Veckeneer, Marc   +3 more
doaj   +1 more source

Retinal Pigment Epithelium Responses to Selective Retina Therapy in Mouse Eyes

Investigative Opthalmology & Visual Science, 2016
To investigate the characteristics of retinal pigment epithelium (RPE) and retinal damage induced by selective retina therapy (SRT) in mice, and to elucidate longitudinal changes in RPE cells.C57BL/6J mice received SRT and continuous-wave laser photocoagulation (cwPC).
Hoon Dong, Kim, Sun Young, Jang, Si Hyung, Lee, Young Shin, Kim, Young-Hoon, Ohn, Ralf, Brinkmann, Tae Kwann, Park   +6 more
openaire   +2 more sources