Results 61 to 70 of about 52,550 (248)

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

RETINAL PIGMENT EPITHELIUM CONDITION AFTER LASER AND ULTRASOUND PHACOFRAGMENTATION. ELECTRON MICROSCOPY IN EXPERIMENT. REPORT 1

Офтальмохирургия, 2015
Purpose. To perform a comparative evaluation of a macular retinal pigment epithelium condition after laser and ultrasound phacofragmentations in experiment.Material and method.
S. Y. Kopayev, V. G. Kopayeva, S. A. Borsenok, V. U. Alborova   +3 more
doaj  

Preclinical in vivo dosimetry of healthy tissues in radiopharmaceutical therapy: implementation of a physiologically realistic mouse eye model in GATE

EJNMMI Research
Background Targeted radionuclide therapy is a rapidly growing treatment modality that has shown great promise in managing metastatic cancers. However, the affinity of certain radiopharmaceuticals for off-target healthy tissues necessitates accurate ...
Elodie Jouberton, Nicolas Sas, Tommy Billoux, Philippe Auzeloux, Sébastien Schmitt, Leslie Mazuel, Jean-Michel Chezal, Elisabeth Miot-Noirault, Isabelle Ranchon-Cole, Florent Cachin   +9 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Electronics‐Free Visual Monitoring of Dry Eye Disease‐Related Tear Biomarkers Using Smart Scleral Lenses

Advanced Science, EarlyView.
An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang, Sang Mok Park, Dawn Meyer, Seul Ah Lee, Yumin Dai, Tianhao Yu, Taewoong Park, Feiyang Li, Jason Gerard Jedlicka, Tristan Michael Long, Oluwabunmi T. Oladele, Gillian C. Shaw, Shin Ae Park, Pete S. Kollbaum, Young L. Kim, Chi Hwan Lee   +15 more
wiley   +1 more source

In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes

Ophthalmology Science, 2023
To image healthy retinal pigment epithelial (RPE) cells in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of RPE cell features as a function of age, axial length (AL), and eccentricity.Single-center, exploratory, prospective, and descriptive clinical study.Forty-nine eyes (AL: 24.03 ± 0.93 mm; range: 21.9-26.7 mm) from 29 ...
Kowalczuk, Laura, Dornier, Rémy, Kunzi, Mathieu, Iskandar, Antonio, Misutkova, Zuzana, Gryczka, Aurélia, Navarro, Aurélie, Jeunet, Fanny, Mantel, Irmela, Behar-Cohen, Francine, Laforest, Timothé, Moser, Christophe   +11 more
openaire   +4 more sources

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

Retinal Pigment Epithelium Responses to Selective Retina Therapy in Mouse Eyes

Investigative Opthalmology & Visual Science, 2016
To investigate the characteristics of retinal pigment epithelium (RPE) and retinal damage induced by selective retina therapy (SRT) in mice, and to elucidate longitudinal changes in RPE cells.C57BL/6J mice received SRT and continuous-wave laser photocoagulation (cwPC).
Hoon Dong, Kim, Sun Young, Jang, Si Hyung, Lee, Young Shin, Kim, Young-Hoon, Ohn, Ralf, Brinkmann, Tae Kwann, Park   +6 more
openaire   +2 more sources

Ultra-high resolution optical coherence tomography analysis of bull's eye maculopathy in chloroquine users

Revista Brasileira de Oftalmologia, 2014
Purpose: Register and compare anatomical changes, structural and quantitative found in optical coherence tomography Stratus and Topcon 3D in chronic users of chloroquine.
Celso Morita, Daniel Araujo Ferraz, Thais Zamudio Igami, Beatriz Sayuri Takahashi, Tiago Faria e Arantes, Walter Yukihiko Takahashi   +5 more
doaj   +1 more source