Results 141 to 150 of about 2,960,448 (354)

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Additional file 4 of Integrative analysis of metabolome and transcriptome profiles provides insight into the fruit pericarp pigmentation disorder caused by ‘Candidatus Liberibacter asiaticus’ infection

, 2021
Feiyan Wang, Yunli Wu, Wen Wu, Yongjing Huang, Congyi Zhu, Ruimin Zhang, Jiezhong Chen, Jiwu Zeng   +7 more
openalex   +2 more sources

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

Advanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu   +13 more
wiley   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From 13C and 1H Solid‐State NMR

Angewandte Chemie, EarlyView.
Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink‐Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang   +11 more
wiley   +2 more sources

524 SASH1 is a novel gene involved in human pigmentation disorders [PDF]

, 2017
Adam R. Almeida, Caroline Lambert, Nathaniel B. Goldstein, Stanca A. Birlea, Nabanita Mukherjee, K. P. Janssen, Donald S. Backos, Maranke I. Koster, David A. Norris, Kristin Artinger, Theresa R. Pacheco, Yiqun G. Shellman   +11 more
openalex   +1 more source

Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants

Advanced Science, EarlyView.
Magnetically controllable degradable milliscale swimmers (MDMS) offer a promising alternative to commercial intraocular drug implants, reducing complications like implant dislocation and uncontrolled drug release. MDMS achieve high velocities in ocular environments, enable real‐time imaging, and deliver drugs effectively without disrupting retinal ...
Erdost Yildiz, Ugur Bozuyuk, Eray Yildiz, Fan Wang, Mertcan Han, Alp Can Karacakol, Devin Sheehan, Yan Yu, Metin Sitti   +8 more
wiley   +1 more source

Association of iris pigmentation with hearing disorders in patients presenting at a tertiary care hospital of Punjab, Pakistan.

, 2023
Nauman Aziz, Muskan Shafique, Aman Mehboob, Azka Khan, Muhammad Junaid Iqbal, Muhammad Waseem   +5 more
openalex   +2 more sources

CsPbBr3 Perovskite‐Based Heterostructures in Photocatalysis: Mechanisms, Stability, and Multifunctional Performance

Advanced Science, EarlyView.
This review synthesizes breakthroughs in CsPbBr3 heterostructure photocatalysis: 1) Mechanistic insights on band alignment engineering (Type‐II/Z/S‐scheme) for suppressed charge recombination; 2) Stabilization strategies via interfacial encapsulation and defect passivation overcoming hydrolysis; 3) Multifunctional design principles enabling efficient ...
Kuanxin Lv, Zhenzhen Li, Xing Huang, Zetong Cheng, Zhongyan Wang, Hang Zhao   +5 more
wiley   +1 more source

Bone Density Status and Vitamin D and Calcium Concentrations in Pregnant and Non-Pregnant Women [PDF]

, 2016
Background: The aim of this study was to analyse differences in bone density and vitamin D and calcium concentrations between pregnant and non-pregnant women. Methods: This was an analytical, cross-sectional study of women aged 30 years or over, residing
Adriani, M. (Merryana), Setiarsih, D. (Dini), Wirjatmadi, B. (Bambang)   +2 more
core