Background. The problem of finding new effective plant protection products remains an urgent task of modern agrochemistry. It is known that tetrahydropyridine derivatives exhibit a broad spectrum of biological activity, including fungicidal activity ...
Evgeniya V. Ivanova+5 more
doaj +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Biofluorescent Worlds I: Global Biological Fluorescence as a Biosignature [PDF]
In this paper, we analyze a new possible biological surface feature for habitable worlds orbiting other stars: biofluorescence. High ultraviolet (UV) and blue radiation fluxes drive the strongest biofluorescence in terrestrial fluorescent pigments and proteins.
arxiv +1 more source
Pigment composition of the bright skin in the poison toad, Melanophryniscus rubriventris (Anura: Bufonidae) from Argentina [PDF]
The determination of the basis of skin colour is important to better understand the evolutionary and ecological relevance of colour variation in aposematic species.
Bonansea, Maria Ines+2 more
core
Growth, photosynthetic pigments, phenolic content and biological activities of Foeniculum vulgare Mill., Anethum graveolens L. and Pimpinella anisum L. (Apiaceae) in response to zinc [PDF]
The effect of zinc (Zn) on phenols, antioxidant activities (free radicals' scavenging activities, inhibition of lipid peroxidation, chelating activity and reducing power), and enzyme inhibition activities of acetylcholinesterase, lipoxygenase and ...
Ben Kaab, Leila Bettaieb+6 more
core +1 more source
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren+8 more
wiley +1 more source
Delocalized Electronic Excitations and their Role in Directional Charge Transfer in the Reaction Center of Rhodobacter Sphaeroides [PDF]
In purple bacteria, the fundamental charge-separation step that drives the conversion of radiation energy into chemical energy proceeds along one branch - the A branch - of a heterodimeric pigment-protein complex, the reaction center. Here, we use first principles time-dependent density functional theory (TDDFT) with an optimally-tuned range-separated ...
arxiv
Artificial photosynthetic reaction centers coupled to light-harvesting antennas [PDF]
We analyze a theoretical model for energy and electron transfer in an artificial photosynthetic system. The photosystem consists of a molecular triad (i.e., with a donor, a photosensitive unit, and an acceptor) coupled to four accessory light-harvesting antennas pigments.
arxiv +1 more source
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui+5 more
wiley +1 more source