Results 51 to 60 of about 542,971 (347)

Run 2 Upgrades to the CMS Level-1 Calorimeter Trigger [PDF]

, 2015
The CMS Level-1 calorimeter trigger is being upgraded in two stages to maintain performance as the LHC increases pile-up and instantaneous luminosity in its second run.
Aggleton, R., Apanasevich, L., Baber, M., Ball, F., Barbieri, R., Beaudette, F., Berryhill, J., Brooke, J., Bundock, A., Cadamuro, L., Cali, I. A., Cavanaugh, R., Cepeda, M., Citron, M., Dasu, S., Dodd, L., Durkin, T., Elwood, A., Forbes, R., Foudas, C., Gorski, T., Guilbaud, M., Hall, G., Harder, K., Harper, S., Iles, G., Innocenti, G. M., Klabbers, P., Kreis, B., Laner, C., Lee, Y. -J., Levine, A., Li, W., Marrouche, J., Mastrolorenzo, L., Mishra, K., Newbold, D., Northup, M., Ojalvo, I., Paramesvaran, S., Penning, B., Rivera, R., Roland, C., Romanteau, T., Rose, A., Ruggles, T., Sauvan, J. B., Shepherd-Themistocleous, C., Smith, D., Smith, N., Smith, W., Strebler, T., Svetek, A., Tapper, A., Thea, A., Tikalsky, J., Tran, B., Uplegger, L., Vicente, M., Wardle, N., Williams, T., Wyslouch, B., Zabi, A., Zhang, J.   +63 more
core   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Relaxation Dynamics of a Granular Pile on a Vertically-Vibrating Plate

, 2018
Nonlinear relaxation dynamics of a vertically-vibrated granular pile is experimentally studied. In the experiment, the flux and slope on the relaxing pile are measured by using a high-speed laser profiler.
Katsuragi, Hiroaki, Otsuki, Michio, Tsuji, Daisuke   +2 more
core   +1 more source

On Piles [PDF]

The Boston Medical and Surgical Journal
n ...
openaire   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Contact forces in regular 3D granular pile

, 1998
We present exact results for the contact forces in a three dimensional static piling of identical, stiff and frictionless spheres. The pile studied is a pyramid of equilateral triangular base (``stack of cannonballs'') with a FCC (face centered cubic ...
Brockbank, Claudin, Edwards, G. Oron, H.J. Herrmann, Hong, Huntley, Liffman, Liffman, Luding, Wittmer   +10 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Post-yield characterisation of metals with significant pile-up through spherical indentations

, 2006
Finite element simulations of spherical indentations accounting for frictional contact provide validated load–indentation output for assessing and improving existing methods used to determine the stress–strain curve of materials with significant pile-up.
Habbab, H., Mellor, B.G., Syngellakis, S.   +2 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

High count rate {\gamma}-ray spectroscopy with LaBr3:Ce scintillation detectors

, 2012
The applicability of LaBr3:Ce detectors for high count rate {\gamma}-ray spectroscopy is investigated. A 3"x3" LaBr3:Ce detector is used in a test setup with radioactive sources to study the dependence of energy resolution and photo peak efficiency on ...
B. Löher, D. Savran, Devanathan, E. Fiori, Iltis, Kulisek, Kurosawa, M. Miklavec, M. Vencelj, Milbrath, Moses, Moszynski, Moszynski, N. Pietralla, Novak, Quarati, Régis, Smith, van Loef, Vencelj, Zhu   +20 more
core   +1 more source