Results 1 to 10 of about 17,022 (157)

Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy

Neurobiology of Disease, 2016
Astroglia, the most abundant glial cells in the mammalian central nervous system (CNS), are considered an emerging key player in seizure induction and progression. Although astrocytes undergo reactive gliosis in temporal lobe epilepsy (TLE) with dramatic
Jerome Clasadonte, Lydie Morel, Camila M. Barrios-Camacho, Ming Sum R. Chiang, Jinhua Zhang, Lakshmanan Iyer, Philip G. Haydon, Yongjie Yang   +7 more
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Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. [PDF]

PLoS ONE, 2016
Carboxypeptidase A6 (CPA6) is an extracellular matrix metallocarboxypeptidase that modulates peptide and protein function by removal of hydrophobic C-terminal amino acids.
Mark William Lopes, Matthew R Sapio, Rodrigo B Leal, Lloyd D Fricker   +3 more
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Influence of Pilocarpine Eyedrops on the Ocular Biometric Parameters and Intraocular Lens Power Calculation

Journal of Ophthalmology, 2023
Objective. To evaluate the influence of pilocarpine eyedrops on the ocular biometric parameters and whether these parameter changes affect the intraocular lens (IOL) power calculation in patients with primary angle-closure glaucoma (PACG).
Ruxin Gao, Jinkun Liu, Xiaojie Zhou, Luping Huang, Weiyi Huang, Yingying Xue, Fei Wang, Songjian Gong, Renyi Wu, Yuhong Wang   +9 more
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Case report: Ten cases of acquired idiopathic generalized anhidrosis treated with oral pilocarpine

Journal of Cutaneous Immunology and Allergy
Acquired idiopathic generalized anhidrosis is a rare disease characterized by systemic anhidrosis or hypohidrosis without other systemic diseases. However, its etiology remains unclear.
Hanako Miyahara, Noriko Kubota, Mari Okune, Yoshiyuki Ishii, Naoko Okiyama, Toshifumi Nomura, Junichi Furuta   +6 more
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In vitro effects of Pilocarpus microphyllus extracts and pilocarpine hydrochloride on Rhipicephalus (Boophilus) microplus

Revista Brasileira de Parasitologia Veterinária, 2016
The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and pilocarpine hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus ...
Karina Neoob de Carvalho Castro, David Fernandes Lima, Dolores Wolschick, Ivanilza Moreira de Andrade, Raimunda Cardoso dos Santos, Francisco José de Seixas dos Santos, Leiz Maria Costa Veras, Lívio Martins Costa-Júnior   +7 more
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Transdermal pilocarpine on the skin over salivary glands to increase salivation: an in vivo study

BMC Oral Health
Background Hyposalivation is treated using oral cholinergic drugs; however, systemic side effects occasionally lead to discontinuation of treatment.
Natsuko Ishida, Ayano Katsura, Koichi Takagaki, Hiroshi Arakawa, Tsutomu Shimada, Satoshi Mizuno, Yoshimichi Sai, Yukio Kato, Hiroyuki Nakamura, Yukio Suga, Ryo Matsushita   +10 more
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Ocular hypotensive effects of a Rho-associated protein kinase inhibitor in rabbits

Clinical Ophthalmology, 2017
Muhammad Irfan Kamaruddin,1,2 Momoko Nakamura-Shibasaki,1 Yu Mizuno,1 Yoshiaki Kiuchi1 1Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Ophthalmology ...
Kamaruddin MI, Nakamura-Shibasaki M, Mizuno Y, Kiuchi Y   +3 more
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Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury

Frontiers in Pharmacology, 2020
Traumatic brain injury (TBI) commonly leads to development of seizures, accounting for approximately 20% of newly diagnosed epilepsy. Despite the high clinical significance, the mechanisms underlying the development of posttraumatic seizures (PTS) remain
Marina Ben Shimon, Efrat Shavit-Stein, Efrat Shavit-Stein, Keren Altman, Chaim G. Pick, Nicola Maggio, Nicola Maggio, Nicola Maggio   +7 more
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Taurine/Pilocarpine Interaction in the Malnourished Rat Brain: A Behavioral, Electrophysiological, and Immunohistochemical Analysis

Frontiers in Neuroscience, 2019
This study aimed to evaluate the possible protective role of taurine on anxiety-like behavior, brain electrical activity and glial cell immunoreactivity in well-nourished and malnourished rats that were treated with a subconvulsing dose of pilocarpine ...
Elian da Silva Francisco, Rosângela Figueiredo Mendes-da-Silva, Cássia Borges Lima de Castro, Geórgia de Sousa Ferreira Soares, Rubem Carlos Araújo Guedes   +4 more
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Evaluation of the neuroprotective effect of taurine and green tea extract against oxidative stress induced by pilocarpine during status epilepticus

Journal of Basic and Applied Zoology, 2015
Status epilepticus (SE) has functional and structural consequences resulting in brain damage. The present study aims to investigate the role of taurine and green tea extract in the neuroprotection against oxidative stress and changes in ...
Neveen A. Noor, Haitham S. Mohammed, Yasser A. Khadrawy, Heba S. Aboul Ezz, Nasr M. Radwan   +4 more
doaj   +1 more source