Results 51 to 60 of about 39,152 (265)

Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy [PDF]

, 2010
High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone.
Cmejla, Roman, Finnerty, Gerald T, Jefferys, John G R, Jiruska, Premysl, Lofti, Noosheen, Powell, Andrew D   +5 more
core   +3 more sources

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Primary argon laser trabeculoplasty vs pilocarpine 2% in open angle glaucoma : Two years follow-up study

Indian Journal of Ophthalmology, 1997
In a prospective study, the efficacy of argon laser trabeculoplasty (ALT) was evaluated and compared with pilocarpine 2% as primary treatment in newly diagnosed primary open angle glaucoma (POAG).
Sharma Ashok, Gupta Amod
doaj  

Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus

Neurobiology of Disease, 2012
Mouse strains differ from one another in their susceptibility to seizure-induced excitotoxic cell death. Previously, we have demonstrated that mature inbred strains of mice show remarkable genetic differences in susceptibility to the neuropathological ...
P. Elyse Schauwecker
doaj   +1 more source

Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms [PDF]

International Journal of Ophthalmology, 2016
AIM: To examine the cytotoxic effect of pilocarpine, an anti-glaucoma drug, on human corneal stromal (HCS) cells and its underlying cytotoxic mechanisms using an in vitro model of non-transfected HCS cells.
Xiao-Long Yuan, Qian Wen, Meng-Yu Zhang, Ting-Jun Fan   +3 more
doaj   +1 more source

The site of emetic action of veratrum derivatives. [PDF]

, 1951
Thesis (M.A.)--Boston ...
Swiss, Edward D
core   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

A Systematic Review and Meta-Analysis on the Efficacy and Safety of Topical Pilocarpine 1.25% in Presbyopia Treatment

Journal of Current Ophthalmology
Purpose: To do a qualitative and quantitative assessment of the existing literature on the effectiveness and safety of pilocarpine 1.25% eye drops in presbyopia management. Methods: Relevant articles were extracted from the online database using keywords
Mamta Singh, Bibhuti Prassan Sinha, Siddhartha Dutta, Kunal Khanderao Deokar, Deepak Mishra, Khyati Goswami   +5 more
doaj   +1 more source

Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy

Neurobiology of Disease, 2016
Astroglia, the most abundant glial cells in the mammalian central nervous system (CNS), are considered an emerging key player in seizure induction and progression. Although astrocytes undergo reactive gliosis in temporal lobe epilepsy (TLE) with dramatic
Jerome Clasadonte, Lydie Morel, Camila M. Barrios-Camacho, Ming Sum R. Chiang, Jinhua Zhang, Lakshmanan Iyer, Philip G. Haydon, Yongjie Yang   +7 more
doaj   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source