Results 61 to 70 of about 17,022 (157)

Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico?

Arquivos de Neuro-Psiquiatria, 2010
The objective of the present study was to evaluate the neuroprotective effects of ascorbic acid (AA) in rats, against the neuronal damage and memory deficit caused by seizures.
Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas   +2 more
doaj   +1 more source

Construction of a pilocarpine-induced temporal lobe epilepsy model in mice based on severe seizure behavior

Zhongguo Linchuang Yixue
Objective To explore the approach to establish a temporal lobe epilepsy model via intraperitoneal pilocarpine injection in C57BL/6J mice, and to summarize behavioral indicators predicting successful modeling during the acute phase of epileptic seizures ...
Fangchao TONG, Yiying CAI, Yuanfang LI, Qiang WANG, Jing DING, Xin WANG   +5 more
doaj   +1 more source

The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

Frontiers in Neurology, 2019
The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is involved in many central nervous system diseases, including epilepsy.
Natália Ferreira Mendes, Aline Priscila Pansani, Elis Regina Ferreira Carmanhães, Poliana Tange, Juliana Vieira Meireles, Mayara Ochikubo, Jair Ribeiro Chagas, Alexandre Valotta da Silva, Glaucia Monteiro de Castro, Luciana Le Sueur-Maluf   +9 more
doaj   +1 more source

Pilocarpine [PDF]

Reactions Weekly, 2020
  +4 more sources

Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia

Journal of Dental Research, Dental Clinics, Dental Prospects, 2013
Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its ...
Farid Abbasi, Sareh Farhadi, Mostafa Esmaili   +2 more
doaj   +1 more source

Efficacy of combined administration of Baekhogainsam-Tang and low-dose pilocarpine on frequent intractable xerostomia: Study protocol for a randomized controlled trial.

PLoS ONE
BackgroundIntractable xerostomia is defined as the subjective perception of dry mouth and persistent salivary gland hypofunction. Pilocarpine is an approved salivary sialagogue that is frequently prescribed for the treatment of intractable xerostomia ...
Su Il Kim, Young Chan Lee, Ji Won Kim, Bo-Hyung Kim, Junhee Lee, Young-Gyu Eun   +5 more
doaj   +1 more source

Development and characterization of niosomes loaded mucoadhesive biodegradable ocular inserts for extended release of pilocarpine HCl

Future Journal of Pharmaceutical Sciences
Background Pilocarpine HCl is a non-selective muscarinic receptor agonist that is prescribed for the treatment of glaucoma. The use of pilocarpine conventional eye drops is associated with several side effects, such as loss of visual acuity, and the need
Tamara Ahmad Alotaibi, Affiong Iyire, Shereen Assaf, Eman Zmaily Dahmash   +3 more
doaj   +1 more source

Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential

Medicina
Background and Objectives: Pilocarpine is used in experimental studies for testing antiepileptic drugs, but further characterization of this model is essential for its usage in testing novel drugs. The aim of our study was to study the behavioral and EEG
Dolika Vasović, Olivera Stanojlović, Dragan Hrnčić, Nikola Šutulović, Milena Vesković, Aleksandar J. Ristić, Nebojša Radunović, Dušan Mladenović   +7 more
doaj   +1 more source

Efficacy and Safety of Pilocarpine Eye Drops Combinations for Treating Presbyopia in a Thai Population: A Randomized Crossover Trial

Siriraj Medical Journal
Objective: This study aimed to assess and compare the effectiveness and side effects of various concentrations of pilocarpine eye drops (1.5%, 1.25%, and 1%), with and without 0.1% brimonidine, in treating presbyopia, specifically in a Thai population.
Thammanoon Surachatkumtonekul, Pinpilai Jutasompakorn, Anchalika Klinniyom, Wasawat Sermsripong, Kiatthida Hokierti, Prapasson Sangsre, Ketchanya Rungsiri   +6 more
doaj  

Intranasal Diazepam Outperforms Midazolam and Lorazepam in Early Seizure Control in Pilocarpine-Induced Mice Model. [PDF]

Neurochem Res
Tong AH, Zhao J, Li J, Ban W, Wang RJ, Xie Y, Zhang Y, Zuo Z.   +7 more
europepmc   +1 more source