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Axonal Transport Deficits in Parkinson's Disease: Insights from Neurotoxin, Genetic, and Sporadic Models. [PDF]
Brain SciWang X, Liu Z, Smith WW.
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Effect of yeast selenium on autophagy and PINK1/Parkin expression in Diquat-induced chicken liver and kidney cells. [PDF]
Poult SciJin Y +6 more
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Dietary 3,4-Dihydroxybenzalacetone alleviates LPS-induced intestinal injury in Leizhou black ducks by improving mitochondrial function and suppressing apoptosis. [PDF]
Poult SciYang W, Ma W, You Y, Ma Y, Wu H, Chen Z.
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Hsp70 participates in PINK1-mediated mitophagy by regulating the stability of PINK1
Neuroscience Letters, 2018Loss-of function mutations in PTEN-induced putative kinase 1 (PINK1) is one of the most common causes of autosomal recessive Parkinson's disease (PD). PINK1-mediated mitophagy is critical to mitochondrial quality control and plays an important role in PD pathogenesis.
Jifeng Guo, Jieqiong Tan, Chunyu Wang
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Autophagy
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Armaan Fallahi +2 more
exaly +3 more sources
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Armaan Fallahi +2 more
exaly +3 more sources
Biochemical and Biophysical Research Communications, 2023
Parkinson's disease is presently thought to have its molecular roots in the alteration of PINK1-mediated mitophagy and mitochondrial dynamics. Finding new suppressors of the pathway is essential for developing cutting-edge treatment approaches. Our study shows that FUNDC1 suppressed PINK1 mutant phenotypes in Drosophila.
Jing, Xu +4 more
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Parkinson's disease is presently thought to have its molecular roots in the alteration of PINK1-mediated mitophagy and mitochondrial dynamics. Finding new suppressors of the pathway is essential for developing cutting-edge treatment approaches. Our study shows that FUNDC1 suppressed PINK1 mutant phenotypes in Drosophila.
Jing, Xu +4 more
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PINK1: The guard of mitochondria
Life Sciences, 2020PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has been highlighted for its role in early-onset Parkinson's disease. In recent years, an increasing number of studies have revealed the involvement of PINK1 in regulation of a variety of cell physiological and pathophysiological processes, of which regulation of ...
Nan, Wang +8 more
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Science, 2014
Mitochondria lacking a Parkinson’s disease–associated kinase harbor a functionally important phosphorylation defect.
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Mitochondria lacking a Parkinson’s disease–associated kinase harbor a functionally important phosphorylation defect.
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PINK1 and Parkin: The odd couple
Neuroscience Research, 2020In 2004, PINK1 was established as a gene linked to early onset of autosomal recessive juvenile Parkinsonism. Since then, tremendous efforts allowed involving the gene product in diverse events but with a strong focus on its partnership with the protein Parkin for the degradation of damaged mitochondria through mitophagy.
Yoboue, Edgar Djaha, Valente, Enza Maria
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