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Molecular Mechanisms of PINK1-Related Neurodegeneration
Current Neurology and Neuroscience Reports, 2011PINK1 is a mitochondrially targeted kinase that has been linked to a rare monogenic form of Parkinson's disease (PD), a common neurodegenerative disease characterized by the degeneration of selected dopaminergic neurons. Intensive research using many model systems has clearly established a fundamental role for PINK1 in preventing mitochondrial ...
Joe H, Pogson +2 more
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Parkin stabilizes PINK1 through direct interaction
Biochemical and Biophysical Research Communications, 2009Parkinson disease (PD) is the most common movement disorder and is characterized by dopaminergic dysfunction. The majority of PD cases are sporadic; however, the discovery of genes linked to rare familial forms of the disease has provided crucial insight into the molecular mechanisms of disease pathogenesis.
Kahori, Shiba +6 more
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Induction of PINK1/Parkin-Mediated Mitophagy
2017PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are activated to promote the proteasomal degradation of mitochondrial outer membrane proteins and selective elimination of ...
Shigeto, Sato, Norihiko, Furuya
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iPS models of Parkin and PINK1
Biochemical Society Transactions, 2015Parkinson disease (PD) is a degenerative disorder of the central nervous system resulting from depletion of dopaminergic neurons and currently remains incurable despite enormous international research efforts. The development of induced pluripotent stem cell (iPSC) technology opened up the unique possibility of studying disease mechanisms in human ...
Aleksandar, Rakovic +2 more
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[Molecular genetics of PINK1].
Brain and nerve = Shinkei kenkyu no shinpo, 2007PTEN-induced putative kinase 1 (PINK1) is a causative gene for autosomal recessive early onset parkinsonism. Mutations in PINK1 were identified originally in PARK6-linked parkinsonism families from Italy and Spain. PINK1 contains 8 exons spanning 1.8 kb, and encodes a protein of 581 amino acids with a mitochondrial targeting motif and a serine ...
Manabu, Funayama, Nobutaka, Hattori
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PINK1: Multiple mechanisms of neuroprotection
2021Britney N, Lizama +2 more
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Autophagy
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development
Cell, 2023Panagiotis D Velentzas, Eric H Baehrecke
exaly