Results 91 to 100 of about 23,348 (143)

Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus [PDF]

, 2006
Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Balkau, Forst, Haffner, Haffner, Hedblad, Howard, Huupponen, Langenfeld, Maseri, Matthews, Morrow, Nissen, Paice, Pfützner, Pfützner, Pfützner, Pfützner, Pfützner, Pfützner, Pfützner, Ridker, Ridker, Ridker, Ridker, Ridker, Ridker, Riveline, Ross, Saito, Sellmayer, Serrano Rios, Simpson, Willerson, Yudkin   +33 more
core   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Pioglitazone improves in vitro viability and function of endothelial progenitor cells from individuals with impaired glucose tolerance.

PLoS ONE, 2012
BackgroundEvidence suggests that the PPARγ-agonist insulin sensitizer pioglitazone, may provide potential beneficial cardiovascular (CV) effects beyond its anti-hyperglycaemic function.
Valentina Spigoni, Angela Picconi, Monia Cito, Valentina Ridolfi, Sabrina Bonomini, Chiara Casali, Ivana Zavaroni, Luigi Gnudi, Marco Metra, Alessandra Dei Cas   +9 more
doaj   +1 more source

Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices

Clinical Anatomy, Volume 39, Issue 3, Page 325-331, April 2026.
ABSTRACT Recently, great attention has been given to understanding the new pathogenetic mechanisms underlying aortic stenosis (AS). The study aims to understand the role of mature adipocytes in AS and their association with histologic, clinical, and echocardiographic data, an area previously overlooked in AS research.
Elena Zoico, Tanaz Saatchi, Silvia Urbani, Vanni Rizzatti, Gloria Mazzali, Francesco Fantin, Silvia Faccioli, Alessandro Gavras, Mauro Zamboni, Anna Giani   +9 more
wiley   +1 more source

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]

, 2011
OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael, Jick, Susan S., Krähenbühl, Stephan, Meier, Christian, Meier, Christoph R.   +4 more
core   +2 more sources

Assessing Research Impact With Bibliometrics and Altmetrics: The Case of the Canadian Network for Observational Drug Effect Studies (CNODES)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Purpose Our purpose was to measure the research output and impact of the Canadian Network for Observational Drug Effect Studies (CNODES). Methods We used OpenAlex to collect metadata on citation counts for all 115 CNODES articles published between January 2011 and March 2022. We obtained the altmetric scores from Altmetric.com.
Alexandra M. Yip, Ingrid S. Sketris, Samuel A. Stewart, Pauline Reynier, Philippe Mongeon, Kristian B. Filion   +5 more
wiley   +1 more source

P-537: Pioglitazone blunts the blood pressure response to angiotensin II in insulin-resistant zucker rats [PDF]

, 2017
Thiazolidinediones are high-affinity agonists of peroxisome proliferator-activated receptors (PPAR)-γ which have been found to lower blood pressure (BP) in animal models of diabetes and reno-vascular hypertension.
Brunner, Hans R., Burnier, Michel, Maillard, Marc, Nussberger, Juerg, Perregaux, Christine, Zanchi, Anne   +5 more
core  

The Pecularities of Correlation Between Insulin Resistance, Carbohydrate and Lipid Metabolism Indices in Patients with Graves'disease [PDF]

, 2017
Aim. The number of patients with endocrine disorders in the world, in particular, Graves' disease is continuously increasing. Recent studies have determined the fact of insulin resistance in thyroid disorders.
Kikhtyak, O. (Olesya), Lishchuk, O. (Orysia), Moskva, K. (Khrystyna)   +2 more
core   +2 more sources

The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta‐Analysis

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
SGLT2 inhibitors reduce skeletal muscle mass modestly in older adults with type 2 diabetes. Forest plot (a) and count our funnel plot (b) show a small but significant pooled reduction in muscle mass (SMD = −0.36, 95% CI [−0.56, −0.15]; I2 = 24.1%), with weight loss occurring predominantly through fat mass reduction.
Weena Joongpan, Nittaya Boonmuen, Pimthong Sinchai, Sarawut Lapmanee, Natawat Klamsakul, Nutthapoom Pathomthongtaweechai   +5 more
wiley   +1 more source

Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Ameliorates Chronic Kidney Disease by Enhancing Antioxidative Capacity and Attenuating Angiogenesis in the Kidney of a 5/6 Nephrectomized Rat Model

Cellular Physiology and Biochemistry, 2016
Background/Aims: Pioglitazone is a type of peroxisome proliferator-activated receptor γ agonist and is capable of alleviating renal ischemia-reperfusion injury.
Li Sun, Quan Yuan, Tianhua Xu, Li Yao, Jiangmin Feng, Jianfei Ma, Lining Wang, Changlong Lu, Danan Wang   +8 more
doaj   +1 more source