Results 41 to 50 of about 3,933 (191)

Role of Colesevelam in Combination Lipid-Lowering Therapy [PDF]

, 2013
Hyperlipidemia is associated with an increased risk of cardiovascular events; reducing low-density lipoprotein cholesterol (LDL-C), the primary target for cholesterol-lowering therapy, lowers the risk for such events. Although bile acid sequestrants were
Michael R. Jones, Oliseyenum M. Nwose
core   +1 more source

Simultaneous estimation of metformin hydrochloride and pioglitazone hydrochloride by RPHPLC method from combined tablet dosage form

Indian Journal of Pharmaceutical Sciences, 2008
A high performance reverse phase liquid chromatographic procedure is developed for simultaneous estimation of metformin hydrochloride and pioglitazone hydrochloride in combined tablet dosage form. The mobile phase used was a combination of acetonitrile:water:acetic acid (60:40:0.3) and the pH was adjusted to 5.5 by adding triethylamine.
Sahoo, P. K., Sharma, R., Chaturvedi, S. C.   +2 more
openaire   +3 more sources

Effective utilization of oral hypoglycemic agents to achieve individualized HbA1c targets in patients with type 2 diabetes mellitus [PDF]

, 2016
YesType 2 diabetes is a progressive condition that may require the combination of three oral treatments to achieve optimal glycemic management to prevent microvascular and macrovascular complications whilst minimizing the risk of acute complications and ...
Bannister, Margaret, Berlanga, J.
core   +2 more sources

Box–Behnken design assisted HPTLC method for quantification of teneligliptin hydrobromide hydrate, metformin hydrochloride and pioglitazone hydrochloride in pharmaceutical dosage form

Discover Chemistry
A Design of expert approach was used to develop and validate a high-performance thin layer chromatography method for simultaneously determining Teneligliptin hydrobromide hydrate, Metformin hydrochloride, and Pioglitazone hydrochloride in tablets.
Patel Kalpana, Babariya Raj, Shah Hitaxi, Tandel Devang, Patel Subhashchandra, Gandhi Tejal   +5 more
doaj   +1 more source

Integrated LC–MS/MS bioanalysis for the simultaneous quantification of metformin HCl, pioglitazone HCl, and teneligliptin HBr hydrate in human plasma

Journal of Applied Pharmaceutical Research
Background: Combination therapy is widely prescribed in Type II diabetes mellitus to maintain effective glycemic control. The rising use of multidrug regimens demands selective and reliable bioanalytical methods capable of simultaneously quantifying ...
Sejal H. Pandya, Hitesh J. Vekariya
doaj   +1 more source

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

Organ Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

Emerging pharmacotherapy for cancer patients with cognitive dysfunction [PDF]

, 2013
Advances in the diagnosis and multi-modality treatment of cancer have increased survival rates for many cancer types leading to an increasing load of long-term sequelae of therapy, including that of cognitive dysfunction.
A Parachikova, A Prakash, B Gagnon, BP Daly, C Cunningham, C Gottesmann, CD Aluise, CJ Nelson, CM Reid, D Greene-Schloesser, D Holmes, D Jaturapatporn, D Kim, David M Ashley, DD Correa, EE Lower, EG Shaw, EJ Jacobs, EM Yazlovitskaya, ES Yang, F Joly, F Xia, Fiona M Ahlberg, G Winocur, G Winocur, H Cimarosti, HG Mar Fan, HM Conklin, J Kim, J Lindsay, JC Adair, JH Kang, JM Leoutsakos, JS Wefel, JS Wefel, JS Wefel, Justin Davis, K Gehring, K Hermelink, K Hermelink, L Blackhall, L Lundorff, M Batalo, M Berbee, M Berk, M Inouye, M Khasraw, M Khasraw, M Khasraw, MC Janelsins, ME Robbins, Michael Berk, MJR Howes, Mustafa Khasraw, N Biglia, N Volkow, PD Brown, RK Mulhern, S Kohli, SJ Thompson, SM Castellino, T Scammell, TE Wilens, TM Engber, V Dutta, V Tiwari, W Lasheen, Y Liu   +67 more
core   +2 more sources

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, Volume 21, Issue 1, January 2026.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

TRIPS implementation and secondary pharmaceutical patenting in Brazil and India [PDF]

, 1978
This article compares national approaches toward secondary pharmaceutical patents. Because secondary patents can extend periods of exclusivity and delay generic competition, they can raise prices and reduce access to medicines. Little is known about what
Bhaven N. Sampat, Kenneth C. Shadlen, T Amin, M Basso, ER Berndt, P Drahos, P Drahos, R Falvey, R Falvey, J Farrell, KM Gopakumar, CS Hemphill, CS Hemphill, CS Hemphill, L Howard, O Ivus, A Kapczynski, A Kapczynski, VYM Kunisawa, MK Kyle, S La Croix, M Lemley, M Liu, J-F Morin, WG Park, Y Qian, BN Sampat, FM Scherer, A Sengupta, KC Shadlen, KC Shadlen, CM Sweet, N Vernaz   +32 more
core   +1 more source

Sustainable RP‐HPLC Approach for Profiling Pioglitazone and Related Substances

Journal of Chemistry, Volume 2026, Issue 1, 2026.
A sustainable RP‐HPLC method for the comprehensive fingerprinting of pioglitazone and its related substances was developed and validated in alignment with green analytical chemistry principles. Utilizing eco‐friendly solvents and reducing waste generation were used to optimize chromatographic conditions.
Tahani Y. A. Alanazi, Samar M. Mahgoub, Fahad M. Alminderej, Yasmeen G. Abou El-Reash, Omkulthom Al kamaly, Sayed M. Saleh, Mahmoud A. Mohamed, Munmun Bardhan   +7 more
wiley   +1 more source