Results 121 to 130 of about 58,639 (259)
FEBS Open Bio, 2014 While most attention has been focused on physiologically generated blebs, the molecular mechanisms for fixation-induced cell blebbing are less investigated. We show that protein-fixing (e.g. aldehydes and picric acid) but not lipid-stabilizing (e.g. OsO4
Siyuan Zhao +5 more
doaj +1 more source
Examining the role of insulin in the regulation of cardiovascular health [PDF]
, 2013 A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core +1 more source
PIP2 Influences the Conformational Dynamics of Membrane bound KRAS4b
bioRxiv, 2019 KRAS4b is a small GTPase involved in cellular signaling through receptor tyrosine kinases. Activation of KRAS4b is achieved through the interaction with nucleotide exchange factors while inactivation is regulated by through interaction with GTPase ...
M. McLean, A. Stephen, S. Sligar
semanticscholar +1 more source
Journal of Anatomy, EarlyView.The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell +6 more
wiley +1 more source
Dual Regulation of Kv1.2 Activation by PIP2 [PDF]
Biophysical Journal, 2011 Phosphatidylinositol (4,5)-bisphosphate is now recognized as a ubiquitous regulator of ion channels and transporters. We report here that PIP2 regulates activation of Kv1.2, a Shaker family voltage-gated potassium channel. In inside-out macropatches of Xenopus laevis oocytes, loss of PIP2 induced a leftward shift in the voltage-dependence of activation
Rodriguez-Menchaca, Aldo A. +2 more
openaire +1 more source
So far, yet so close: α-Catenin dimers help migrating cells get together [PDF]
, 2017 Epithelial cells in tissues use their actin cytoskeletons to stick together, whereas unattached cells make active plasma membrane protrusions to migrate. In this issue, Wood et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612006) show that the
Benjamin +12 more
core +2 more sources
Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception
Orthodontics &Craniofacial Research, EarlyView.ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley +1 more source
SALM1 controls synapse development by promoting F‐actin/PIP2‐dependent Neurexin clustering
EMBO Journal, 2019 Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis‐regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified synaptic
Marinka Brouwer +10 more
semanticscholar +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Calcium ion (Ca2+) is an essential plant nutrient required for cell structure establishment, as well as a counter‐cation of an anion and an intracellular messenger. Calcium is absorbed from soil by roots and delivered to shoots through the xylem. The process must be finely balanced to avoid excessive accumulation.
Bojuan Liu +10 more
wiley +1 more source
Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice [PDF]
, 2015 Spiral ganglion neurons (SGNs) relay acoustic code from cochlear hair cells to the brainstem, and their stimulation enables electrical hearing via cochlear implants. Rapid adaptation, a mechanism that preserves temporal precision, and a prominent feature
Browne, L +4 more
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