Results 141 to 150 of about 58,639 (259)
Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα.
PLoS ONE, 2014 The C2 domain of PKCα (C2α) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine.
Antonio L Egea-Jiménez +5 more
doaj +1 more source
PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Despite the availability of many drugs to treat epilepsy, nearly one-third of patients are not responsive to pharmacotherapy. Retigabine (RTG) is the first approved antiepileptic drug that acts by promoting activation of potassium channels ...
Robin Y. Kim, S. Pless, Harley T. Kurata
semanticscholar +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure.
Yu-Jia Zhai +11 more
doaj +1 more source
PKC regulation of ion channels: The involvement of PIP2
Journal of Biological Chemistry, 2022 Kirin D Gada, D. Logothetis
semanticscholar +1 more source
Journal of Biological Chemistry, 2018 Phosphatidylinositol 4,5-bisphosphate (PIP2) in the plasma membrane regulates the function of many ion channels, including M-type (potassium voltage-gated channel subfamily Q member (KCNQ), Kv7) K+ channels; however, the molecular mechanisms involved ...
F. Choveau +4 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Developmental changes in the hair‐bundle structure of outer hair cells (OHCs) and inner hair cells (IHCs) were examined in control and shaker‐1 mutant (Myo7aSh1/Sh1) mice, which carry a spontaneous missense mutation in the Myo7a gene that produces a non‐functional MYO7A protein.
Anna Underhill +7 more
wiley +1 more source
Rsp5 promotes Gene Activation mediated by 9aaTAD Transcription Factors Oaf1 and Gal4 [PDF]
, 2009 Nine-amino-acid transactivation domain, 9aaTAD, defines a large superfamily of yeast and mammals transcription factors. The transactivation of the 9aaTAD has been addressed to multiple general co-activators TAF9, MED15, CBP and p300.
Joachim Lipp +2 more
core +1 more source
Front. Cell Dev. Biol., 2018 Egg activation at fertilization in mammalian eggs is caused by a series of transient increases in the cytosolic free Ca2+ concentration, referred to as Ca2+ oscillations. It is widely accepted that these Ca2+ oscillations are initiated by a sperm derived
Jessica R. Sanders +4 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend During the first few days of development, zebrafish acquire the ability to produce increasingly refined movements that rely progressively less on the activity of primary motoneurons. At the same time, primary motoneurons undergo functional maturation, becoming increasingly capable of repetitive firing.
Stephanie F. Gaudreau, Tuan V. Bui
wiley +1 more source
Dynamic role of the tether helix in PIP2-dependent gating of a G protein–gated potassium channel
The Journal of General Physiology, 2017 G protein–gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases.
Emre Lacin +8 more
semanticscholar +1 more source