Results 121 to 130 of about 73,428 (238)

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Semi‐Reduction of Allenes to Access Deuterated Allylic Isotopomers, Isotopologs and Enantioisotopomers

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Modular and Precise Deuteration: The synthesis of molecules precisely deuterated at allylic, vinylic or both positions remains a challenging task. This work discloses a modular semi‐reductive deuteration that enables the synthesis of various isotopologs including precisely labeled d1‐, d2‐, d3‐, d5‐, and d7‐products.
Lihan Qi, Raviraj Ananda Thorat, Brad D. Maxwell, Jeffery A. Gladding, Aniel J. Rivera Arzola, Shashank P. Sancheti, Reilly E. Sonstrom, Xulin Tang, Isaac J. Anderson, Brooks H. Pate, Joseph R. Clark   +10 more
wiley   +2 more sources

Revised self-consistent continuum solvation in electronic-structure calculations

, 2011
The solvation model proposed by Fattebert and Gygi [Journal of Computational Chemistry 23, 662 (2002)] and Scherlis et al. [Journal of Chemical Physics 124, 074103 (2006)] is reformulated, overcoming some of the numerical limitations encountered and ...
Andreussi, Oliviero, Dabo, Ismaila, Marzari, Nicola   +2 more
core   +3 more sources

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, EarlyView.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 275-281, March/April 2025.
We present an original proof‐of‐concept methodology to probe radical generation from allergens in contact with photoexposed skin, using electron paramagnetic resonance and spin trapping in a reconstructed human epidermis model mimicking real‐life exposure scenarios.
Yannick Port‐Lougarre, Guillaume Voegeli, Bertrand Vileno, Elena Giménez‐Arnau   +3 more
wiley   +1 more source

Pyrene‐Conjugated, 2‐Pyridinecarboxaldehyde Derivatives as N‐Terminus‐Specific Tags for MALDI‐ and LALDI‐MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Background Proteolytic processing is a fundamental post‐translational modification. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) workflows are powerful for degradomic analyses but inherently sacrifice spatial information, a critical aspect for investigating biological systems such as aberrant extracellular matrix remodeling and ...
Mujia Jenny Li, Murat Kucukdisli, Florian Braun, David W. Will, Nadine Meier, Bettina Wehrle, Larissa Chiara Meyer, Melanie Christine Föll, Oliver Schilling   +8 more
wiley   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, Volume 121, Issue 4, Page 870-882, April 2026.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Effects of Cannabidiol on TAFAZZIN‐Deficient B‐Lymphoblastoid Cells

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Deficiency of the cardiolipin remodeling enzyme TAFAZZIN causes Barth syndrome (BTHS), resulting in cardiolipin loss, monolysocardiolipin (MLCL) accumulation, and electron transport chain (ETC) abnormalities in B‐lymphoblastoid cells. Effects of the non‐psychotropic phytocannabinoid cannabidiol (CBD) were examined on B‐lymphoblastoid cells from ...
John Z. Chan, Antonia N. Berdeklis, Ming Rong Liu, Fasih A. Rahman, Michelle V. Tomczewski, Mackenzie Q. Graham, Musa Musa, Alex D. Cocco, Ken D. Stark, Joe Quadrilatero, Robin E. Duncan   +10 more
wiley   +1 more source

Mehr als nur ein biochemischer Puffer: Tris als Designer und Regulator einer Metall–Oxo‐Assemblierung

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Tris(hydroxymethyl)aminomethan – schematisch als Oktopus dargestellt – wirkt gleichzeitig als Alkoxy‐Ligand, Chelator und strukturleitender Puffer und programmiert in Wasser die Speziation, die Nukleation und die Heterometall‐Insertion von Polyoxometallaten. ZUSAMMENFASSUNG Polyoxometallate (POMs; molekulare Metall–Oxo‐Cluster) werden typischerweise in
Nadiia I. Gumerova, Annette Rompel
wiley   +1 more source