Results 61 to 70 of about 73,428 (238)

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Four human (h) carbonic anhydrase isoforms (CA, EC 4.2.1.1), hCA I, II, IV, and VII, were investigated for their activation profile with piperazines belonging to various classes, such as N-aryl-, N-alkyl-, N-acyl-piperazines as well as 2,4-disubstituted ...
Andrea Angeli, Niccolò Chiaramonte, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran   +4 more
doaj   +1 more source

Thermal Degradation and Corrosion of Amines for CO2 Capture [PDF]

, 2015
This report examines the thermal degradation and corrosion of various amine solvents as they apply to amine scrubbing for CO2 capture. Amines were placed in stainless steel cylinders and heated in convective ovens to simulate the stripping conditions ...
Hatchell, Daniel
core  

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade

Angewandte Chemie, EarlyView.
A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra, Ruzal Sitdikov, Hasil Aman, Alyssio Calis, Gergely Laczkó, Virgile Rouffeteau, Maxime R. Vitale, Imre Pápai, Oscar Verho   +8 more
wiley   +2 more sources

Effect of different Dosage Infection Ascaridia galli and Piperazine Treatment on Total Worm and Layers’ Body Weight

Animal Production: Indonesian Journal of Animal Production, 2009
The aim of this research was to study effect of different dosage Infection Ascaridia galli (A. galli) and anthelmintic piperazine treatment to total worm and layers’ body weight. The research was based on Randomized Completely Design with Factorial (3x2)
L Zalizar, F Satrija
doaj  

Scalable Layer‐by‐Layer Electrospray‐Assisted Interfacial Polymerization: Enabling Large‐Area Polyamide Membrane Fabrication

Advanced Materials Technologies, EarlyView.
We report a multi‐jet, layer‐by‐layer electrospray‐assisted interfacial polymerization (LBL‐EAIP) approach for the scalable fabrication of polyamide reverse osmosis (RO) membranes. The method enables precise control of polymerization, uniform polyamide coverage, and tunable polyamide film thickness, while delivering consistently high filtration ...
Yue Feng, Feng Gao, Mert Can Hacifazlioglu, Jason Zhao, Jeffrey R. McCutcheon, Yuepeng Zhang   +5 more
wiley   +1 more source

The alpha-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations [PDF]

, 2009
Five-membered secondary amine heterocycles containing an α-heteroatom were prepared and shown to be ineffective as catalysts for the iminium ion catalysed Diels–Alder reaction between cinnamaldehyde and cyclopentadiene.
Cavill, Julie L., Elliott, Richard L., Evans, Gareth, Gibbs, Timothy J. K., Jones, Ian L., Platts, James A, Porzelle, Achim, Tomkinson, Nick   +7 more
core   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents [PDF]

Journal of Medicinal Chemistry, 2017
The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents.
Nishad Thamban Chandrika, Sanjib K. Shrestha, Huy X. Ngo, Oleg V. Tsodikov, Kaitlind C. Howard, Sylvie Garneau-Tsodikova   +5 more
openaire   +2 more sources

Surface‐Bound Superoxide Radical‐Mediated Photo‐Fenton Mineralization of Ciprofloxacin on Fe‐Sillenite Nanosheets

Advanced Science, EarlyView.
This study systematically compares the degradation efficiency of CIP in a H2O2‐alone system and a novel Bi12FeO20‐H2O2 photo‐Fenton system. It reveals for the first time the presence of a quinone‐imine intermediate in the H2O2‐alone system, which exhibits toxicity comparable to CIP.
Wenting Qiu, Ji Liu, Hengjun Shang, Yaning Zhang, Shuai Dou, Jing Xu, Ying Zhang, Yang Lou, Yongfa Zhu, Chengsi Pan   +9 more
wiley   +1 more source