Results 171 to 180 of about 39,960 (300)

PIPERAZINE [PDF]

Chemical & Engineering News Archive, 1957
openaire   +1 more source

Evaluation of Epithelial Integrity in Human Precision‐Cut Kidney Slices

APMIS, Volume 134, Issue 4, April 2026.
ABSTRACT Renal epithelial cells are pivotal in renal regulation of body fluid and electrolyte balance. While rodent models are commonly used to study renal physiology, species‐specific differences limit their translational relevance. To bridge this gap, we used human precision‐cut kidney slices (PCKS), an ex vivo tissue‐based model that maintains ...
Gitte A. Pedersen, Benjamin B. Green, Camilla Merrild, Søren H. Elsborg, Mia G. Madsen, Anna K. Keller, Henricus A. M. Mutsaers, Rikke Nørregaard, Lene N. Nejsum   +8 more
wiley   +1 more source

Brief Report: Dolutegravir-Based Therapy, Diet, Physical Activity, and Weight Gain: A 48-week Prospective Cohort in South Africa. [PDF]

J Acquir Immune Defic Syndr
Tien D, Chandiwana N, Shazi G, Chen G, Mabweazara S, Moosa MS, Gupta RK, Pillay D, Marconi VC, Hedt-Gauthier B, Venter WDF, Siedner MJ, McCluskey SM, Manne-Goehler J.   +13 more
europepmc   +1 more source

Piperazine [PDF]

, 2020
openaire   +1 more source

Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones.

Organic Letters, 2016
S. Hsieh, J. Bode
semanticscholar   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Ammonium Zincates as Catalysts for the Microwave-Enhanced Synthesis of Symmetric Piperazines by Regioselective Opening of Aziridines. [PDF]

Chem Asian J
Alberti M, Dariol A, Panza N, Abbiati G, Caselli A.   +4 more
europepmc   +1 more source

Stability of Synthetic Piperazines in Human Whole Blood.

Journal of Analytical Toxicology, 2018
Timothy Lau, Raquel LeBlanc, Sabra R Botch-Jones   +2 more
semanticscholar   +1 more source

Attempts to Achieve Targeted Covalent Inhibition of Hsp90β

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
Electrophilic warheads were incorporated into Hsp90β‐selective inhibitors to covalently modify Lys58, which occupies the solvent‐exposed region of the binding pocket. Although many inhibitors display nanomolar affinity towards Hsp90β over a 24‐h period, analyses to determine covalent bond formation with this residue were inconclusive.
Terin D'Amico, Tyelor S. Reynolds, Michael A. Serwetnyk, Brian S. J. Blagg   +3 more
wiley   +1 more source

Targeting BCL‐xL in Myeloid Malignancies: From Inhibitors to PROTAC

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Restoring apoptosis in malignant cells represents a central goal of anticancer therapy. Tumour cells often escape cell death by overexpressing anti‐apoptotic members of the BCL‐2 protein family, particularly BCL‐2, BCL‐xL, and MCL1. These proteins inhibit the intrinsic mitochondrial apoptotic pathway through intricate interactions with pro ...
Daniela Cilloni, Alessandro Ferrando, Francesco Frassoni   +2 more
wiley   +1 more source