Results 151 to 160 of about 15,176 (256)

The toxicology and characteristics of fatal new psychoactive stimulant and hallucinogen-related poisonings in Australia, 2000-2025. [PDF]

Drug Alcohol Depend Rep
Darke S, Duflou J, Farrell M, Lappin J, Peacock A.   +4 more
europepmc   +1 more source

Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo, Morena Miciaccia, Maria Grazia Perrone, Antonio Scilimati, Paola Loguercio Polosa, Francesco Bruni   +5 more
wiley   +1 more source

Iridium-Catalyzed Ionic Hydrogenation of Multi-Aza Heterocycles. [PDF]

Angew Chem Int Ed Engl
Despois A, Cramer N.
europepmc   +1 more source

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression. [PDF]

Nat Prod Bioprospect
Zha Z, He D, Song J, Guan Z, Han J, Liu C, Wang X, Zhu Y, Zhu H, Ye W, Li Q, Zhang Y, Zhou Y.   +12 more
europepmc   +1 more source

Synthesis, Characterization, and In Vitro Evaluation of New Amino‐Alcohol Quinolines as Promising Antimycobacterial Agents

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Nontuberculous mycobacteria (NTM) mainly Mycobacterium avium complex (MAC), are emerging pathogens responsible for pulmonary infections. The efficacy of the standard treatment is therefore compromised by the emergence of intrinsic and acquired resistance in MAC.
Elise Si Ahmed Charrier, François Peltier, Jean‐François Raimbert, Marie Perret, Claire Andréjak, Alexandra Dassonville‐Klimpt, Pascal Sonnet   +6 more
wiley   +1 more source

Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]

Chembiochem
He M, Thomson CM, Thompson D, Kuodis V, Smith TK, Dall'Angelo S, O'Hagan D.   +6 more
europepmc   +1 more source

Deprotektive Alkylierung: Eine Plattform zur Umsetzung von Alkoholen zu Aminen mittels Nonafluormesitylensulfonamiden

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
Die direkte Umwandlung von Alkoholen in tertiäre oder sekundäre Amine in einem Reaktionsschritt unter Verwendung von Nms‐Amiden wird beschrieben. Die Transformation zeichnet sich durch eine breite Toleranz gegenüber verschiedenen funktionellen Gruppen und eine hohe Stereospezifität aus, was ihre Eignung für die Synthese isotopenmarkierter Arzneimittel ...
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +2 more sources

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry. [PDF]

ChemistryOpen
Ten A, Koizhaiganova R, Bissenbay D, Tursynova B, Zhaxibayeva Z, Yu V.   +5 more
europepmc   +1 more source