Results 131 to 140 of about 39,960 (300)

EMCDDA trend report for the evaluation of the 2005–12 EU drugs strategy. [PDF]

, 2012
This report has been compiled by the EMCDDA in the first half of 2011 as a supporting document for the external evaluation of the 2005–12 EU drugs strategy and its two 2005–08 and 2009–12 action plans.

core  

Pyrene‐Conjugated, 2‐Pyridinecarboxaldehyde Derivatives as N‐Terminus‐Specific Tags for MALDI‐ and LALDI‐MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Background Proteolytic processing is a fundamental post‐translational modification. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) workflows are powerful for degradomic analyses but inherently sacrifice spatial information, a critical aspect for investigating biological systems such as aberrant extracellular matrix remodeling and ...
Mujia Jenny Li, Murat Kucukdisli, Florian Braun, David W. Will, Nadine Meier, Bettina Wehrle, Larissa Chiara Meyer, Melanie Christine Föll, Oliver Schilling   +8 more
wiley   +1 more source

Synthesis of Some New 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino)-2-pyridyl] piperazines as Anti-HIV [PDF]

Journal of Sciences, Islamic Republic of Iran, 2004
A few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-HIV belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-HIV activity.
doaj  

Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles via decarboxylative asymmetric allylic alkylation [PDF]

, 2019
An enantioselective synthesis of diverse N4-Boc-protected α,α-disubstituted piperazin-2-ones using the palladium-catalyzed decarboxylative allylic alkylation reaction has been achieved.
Hess, Stephan N., Stoltz, Brian M., Sun, Alexander W.   +2 more
core   +1 more source

Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The purification protocol for hypertrophied hepatic stellate cells (hypHSCs) developed in this study, using fibrotic and steatotic mouse livers (CDAHFD model), made it possible to obtain a high‐purity hypHSC preparation for transcriptomic analysis.
Marion Heckmann, Nour‐El‐Houda Djerir, Keola Greliche, Pierre‐Henri Commere, Julien Fernandes, Guillaume Sarrabayrouse, Bernard Hainque, Pascal Bigey, Virginie Escriou, Céline Hoffmann   +9 more
wiley   +1 more source

In Vitro Evaluation of PARP1 Inhibitor Olaparib‐Cyanine Dye Conjugate for the Treatment of Glioblastoma

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo, Faheem, Peter J. Choi, Nicholas J. Pederson, Yuge Liu, Mike Dragunow, Thomas I‐H. Park, Katharine L. Diehl, Jiney Jose   +8 more
wiley   +1 more source

The Relationship Between Catalyst and Solvent in Hydrogenation via Condensed Phase Heterogeneous Catalysis

ChemSusChem, Volume 19, Issue 8, 28 April 2026.
Heterogeneous catalysis has historically been developed in the gas phase, however, we have found it pertinent to highlight solvent effects that must be accounted for in liquid environments. Condensed phase catalysis, like that in biomass, petroleum and the conversion of CO2, stands to benefit from the typically overlooked discussion regarding the ...
Jim B. Floyd, Robert A. Dagle, Jotheeswari Kothandaraman, David J. Heldebrant   +3 more
wiley   +1 more source

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex

Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.
Targeting disease‐linked RNAs with small molecules is often limited by the modest impact of binding RNA structure alone. Here, we present a first‐in‐class bifunctional molecule that degrades the oncogenic lncRNA MALAT‐1 by inducing proximity between the RNA and a cleaving warhead.
Christian A. T. Brega, Benjamin A. Craig, Sigitas Mikutis, Rupert S. J. Proctor, Yuliia Vyborna, Galway Ivey, Maria Eleftheriou, Kostas Tzelepis, Mo Yang, Shaifaly Parmar, Javier Bonet‐Aleta, John S. Schneekloth Jr., Gonçalo J. L. Bernardes   +12 more
wiley   +1 more source

Fast log P determination by ultra-high-pressure liquid chromatography coupled with UV and mass spectrometry detections [PDF]

, 2018
Ultra-high-pressure liquid chromatography (UHPLC) systems able to work with columns packed with sub-2μm particles offer very fast methods to determine the lipophilicity of new chemical entities.
Carrupt, Pierre-Alain, Guillarme, Davy, Henchoz, Yveline, Martel, Sophie, Rudaz, Serge, Veuthey, Jean-Luc   +5 more
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Enzyme‐Assisted Synthesis and In Vitro Characterization of Bifunctional PCSK9 Inhibitors

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important therapeutic target for lowering cholesterol. Here, we report the assembly of a bifunctional molecule combining a PCSK9‐binding peptide with an asialoglycoprotein receptor (ASGPR) ligand.
Yuhui Zhang, Li Wang, Leo Corcilius, Amal K. Reji, Richard J. Payne, Bin Hong, Thomas Durek, Conan K. Wang, David J. Craik   +8 more
wiley   +1 more source