Results 141 to 150 of about 37,689 (286)

Engineering Polymeric Membranes for CO₂ Separation: Materials, Fabrication, Challenges, and Future Perspectives

Carbon Neutralization, Volume 5, Issue 4, July 2026.
Overview of polymeric and mixed‐matrix membranes for CO₂ separation, highlighting key materials, fabrication techniques, performance challenges, and innovations supporting industrial decarbonization and sustainable development. ABSTRACT Carbon dioxide (CO₂) emissions from anthropogenic sources are major contributors to global warming and climate change,
Muhammad Mansha, Noreen Abass, Faizah Altaf, Shehzada Muhammad Sajid Jillani, Safyan Akram Khan, Shahid Ali   +5 more
wiley   +1 more source

1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists

, 2016
This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl)piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3 ...
James B. Thomas (1324521), S. Wayne Mascarella (1307766), Hernán A. Navarro (1309674), F. Ivy Carroll (445446), Juan Pablo Cueva (1315107), Scott P. Runyon (1315095)   +5 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Iron Complexes With Proteins, Carbohydrates, and Maillard Products in Dairy Systems: Implication for Fortification, Bioavailability, and Product Functionality

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 4, July 2026.
ABSTRACT The global prevalence of iron (Fe) deficiency anemia (IDA) continues to pose major public health challenges, necessitating the development of effective fortification strategies. Dairy‐based systems are promising vehicles for Fe fortification and delivery due to their widespread consumption and nutritional value, although their complex matrix ...
Ishara De Silva, Mary Ann Augustin, Thom Huppertz, Julia YQ Low, Arianna Dick, Jayani Chandrapala   +5 more
wiley   +1 more source

Ammonium zincates as catalysts for the selective coupling of aziridines to yield piperazines

, 2023
The piperazine ring is found in many drugs with central pharmacological activity.1 Aziridines, on the other hand, are common synthetic intermediates, as their pronounced geometrical strain allows them to readily perform ring opening reactions under the ...
Caselli, Alessandro, Alberti, Matteo, Dariol, Andrea   +2 more
core  

Geminale Difunktionalisierung von Ketonen durch C–S Bindungs‐insertion photogenerierter Donor–Donor Diazoverbindungen

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Die geminale Difunktionalisierung leicht verfügbarer Bausteine ermöglicht einen schnellen Zugang zu molekularer Komplexität. Diese Arbeit stellt eine Strategie vor, um zwei unterschiedliche funktionelle Gruppen an einem Carbonylkohlenstoff zu installieren, indem dieser in eine Donor–Donor‐Diazo‐Verbindung überführt wird. Die Methode ist sowohl im Batch‐
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

Synthesis, Biological, and Computational Evaluation of Substituted 1-(2-Methoxyphenyl)-4-(1-phenethylpiperidin-4-yl)piperazines and 1-(2-Methoxyphenyl)-4-[(1-phenethylpiperidin-4-yl)methyl]piperazines as Dopaminergic Ligands

, 2016
Sixteen new 1-(2-methoxyphenyl)-4-(1-phenethylpiperidin-4-yl)piperazines and 1-(2-methoxyphenyl)-4-[(1-phenethylpiperidin-4-yl)methyl]piperazines were synthesized to be used as probes for mapping the dopamine D-2 receptor (D(2)DAR) arylpiperazine binding
Kostić-Rajačić, Slađana, Andrić, Deana, Vladimir V. Šukalović, Deana B. Andrić, Penjišević, Jelena, Jelena Z. Penjišević, Roglić, Goran, Kostić Rajačić, Slađana, Šukalović, Vladimir, Vukić Šoškić, Goran M. Roglić, Šoškić, Vukić, Slađana V. Kostić‐Rajačić   +12 more
core   +1 more source

Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

A Generic Approach for Targeting Protein-Protein Interactions Using Multi-functional Piperazines

, 2022
Protein-protein interactions (PPIs) play a pivotal role in most biological processes and misfunction in disease. PPIs have been considered challenging targets for modulation using small molecule ligands, due to their large, comparatively flat ...
Renwick, Suzanne Lynn
core  

Structure‐Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz, Ting Liu, Andreas Krämer, Verena Dederer, Stefan Knapp, Sebastian Mathea, Christian Ducho, Matthias Engel   +7 more
wiley   +1 more source