Results 141 to 150 of about 15,176 (256)

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

A Sensitive Approach for the Determination of the Novel Antidepressant Vilazodone: Electrochemical Sensing Using a Boron‐Doped Diamond Electrode in Surfactant‐Containing Media

ChemistryOpen, Volume 15, Issue 11, November 2026.
The combination of BRBS with Tween 20 enhanced the VLD oxidation signal at ~+0.67 V through surfactant‐assisted adsorption and preconcentration on the BDD electrode surface, resulting in improved sensitivity and signal‐to‐noise ratio. In this study, VLD was also found to undergo oxidation via the piperazine ring through a 2e−/2H+ process at the boron ...
Birdem Bersu İlvan, Ipek Kucuk, Selenay Sadak, Hülya Silah, Bengi Uslu   +4 more
wiley   +1 more source

Nucleophilic Aromatic Substitution in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
In this review, we highlight experimental studies of gas‐phase SNAr. Studying reactions in the gas phase provides invaluable information on intrinsic reactivity by eliminating the complications of solvent effects. Because SNAr is a fundamental reaction in chemical research and organic synthesis, understanding its underlying reactivity and mechanisms is
Daniel N. Hirsch, Damon J. Hinz, Jeehiun K. Lee   +2 more
wiley   +1 more source

Design, Synthesis and Biophysical Characterisation of CPP‐PNA Conjugates for Targeting Oncogenic microRNA‐221

Journal of Peptide Science, Volume 32, Issue 11, November 2026.
Cell‐penetrating peptide‐peptide nucleic acid (CPP‐PNA) conjugates that target the oncogenic microRNA‐221‐5p were synthesised using Cu(I)‐catalysed azide‐alkyne cycloaddition (CuAAC) and disulfide‐mediated conjugation strategies. These constructs form highly stable, sequence‐selective PNA/RNA heteroduplexes and demonstrate preliminary antiproliferative
Martina Rotondo, Françoise Illien, Fabienne Burlina, Barbara Biondi   +3 more
wiley   +1 more source

The present invention relates to a liquid composition containing an active substance belonging to the family of substituted benzhydryl piperazines with reduced amounts of preservatives.

, 2007
The present invention relates to a liquid composition containing an active substance belonging to the family of substituted benzhydryl piperazines with reduced amounts of preservatives.info:eu-repo/semantics ...
Deleers, Michel, Scouvart, Jean, Fanara, Domenico, Poulaint, Claire   +3 more
core  

Synergistic Defect Passivation and Phase Separation Suppression for Efficient Wide‐Bandgap Perovskite and Tandem Photovoltaics

Rare Metals, Volume 45, Issue 11, November 2026.
ABSTRACT Wide‐bandgap perovskite solar cells (WBG PSCs) have attracted significant attention as the top cell in tandem perovskite solar cells. However, the complexity of the composition leads to challenges such as defect formation and phase separation during the crystallization process, which impose significant constraints on the power conversion ...
Suzhen Liu, Wenye Jiang, Binglan Xiong, Sen Jiang, Yingjie Zhu, Yuexin Lin, Wenhan Yang, Tian Zhao, Nan Zhang, Chao Liang   +9 more
wiley   +1 more source

Catalyst-Free Green Synthesis of Dithiocarbamate and Rhodanine Derivatives via C─S and C─N Bond Formation Using N-Substituted Maleimides. [PDF]

Chem Asian J
Satani P, Soliya S, Dutta S, Naveen T.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

In vitro toxicity of piperazine derivatives involves mitochondrial dysfunction and microtubule-related changes in neuronal cell models. [PDF]

BMC Pharmacol Toxicol
Rönnberg D, Jacobsson SOP.
europepmc   +1 more source

Recent Advances in Biogas Production and Upgrading Technologies for Sustainable Energy Systems

GCB Bioenergy, Volume 18, Issue 11, November 2026.
Biogas technology is evolving from waste treatment into an intelligent renewable energy platform. Recent advances in anaerobic digestion, pretreatment, reactor design, biomethane upgrading, and AI‐driven process control improve methane recovery, stability, and gas purity.
Temechew Dessie, Kassa Wudineh Liyew, Eshetu Getahun   +2 more
wiley   +1 more source