Results 161 to 170 of about 39,960 (300)

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

In situ monitoring of cell adhesion kinetics using label‐free optical biosensors: Evaluating anticancer potential and selectivity of natural compounds

VIEW, Volume 7, Issue 2, April 2026.
The limitations of conventional techniques hinder the identification of natural compounds with anticancer potential in terms of speed, throughput, sensitivity, and capability of continuous monitoring of relevant biological effects. Novel label‐free optical biosensors represent new opportunities in the discovery of drug candidates, eliminating these ...
Beatrix Péter, Tim Ausbüttel, Nicolett Kanyo, Péter Joó, Kinga Tóth, Zoltán Szittner, Inna Szekacs, Szilvia Bosze, Gábor M. Kovács, Imre Boldizsár, Robert Horvath   +10 more
wiley   +1 more source

Structural Exploitation of Cinnarizine Identified Novel Drug-Like Anthelmintic Agents Against <i>Angiostrongylus cantonensis</i>. [PDF]

ACS Infect Dis
Lemes BL, Siegl-Breno MA, Silva-Nunes MK, Lopes FB, Silva AS, Motta NEP, de Moraes J, Fernandes JPS.   +7 more
europepmc   +1 more source

Upper Ocean Cycling of Iron South of the Polar Front: Biological Patterns and Processes

Global Biogeochemical Cycles, Volume 40, Issue 4, April 2026.
Abstract Samples from the upper 300 m along the 52°S band, south of the Antarctic Polar Front in the Atlantic sector of the Southern Ocean, including a 3‐week monitoring of a persistent bloom, were analyzed to advance our understanding of iron cycling and supply to recurrent phytoplankton blooms.
Luis M. Laglera, Juan Santos‐Echeandía, Viena Puigcorbé, Christine Klass, Dieter Wolf‐Gladrow   +4 more
wiley   +1 more source

Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus. [PDF]

NPJ Antimicrob Resist
Eke IE, Abdalla BJ, Soverina S, Olive AJ, Cicchetti N, Carey AF, Abramovitch RB.   +6 more
europepmc   +1 more source

Methods for Transition Metal Catalyzed C-N Bond Formation and Organocatalytic Allylation of Aldehydes [PDF]

, 2008
Nordstrøm, Lars Ulrik Rubæk
core  

Cryo‐EM Structures of Alcohol Oxidase Isozymes Reveal Structural Determinants of Cofactor Variation and Enzymatic Activity in Ogataea methanolica

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The methylotrophic yeast, Ogataea methanolica uniquely harbours two alcohol oxidase (AOD) isozymes, Mod1p and Mod2p, which exhibit distinct kinetic properties and are differentially regulated by methanol and oxygen availability, enabling metabolic adaptation to fluctuating environments.
Hao‐Liang Cai, Atsuhiro Shimada, Tasuku Hamaguchi, Akira Mizoguchi, Koji Yonekura, Kyohei Tsuchiyama, Masaya Shimada, Akio Ebihara, Kazutoshi Tani, Tomoyuki Nakagawa   +9 more
wiley   +1 more source

Electrochemical oxidation enables aromatic C-H amination with dual mechanisms. [PDF]

Nat Synth
Stewart G, Alvarez EM, Rapala C, Sklar JH, Kalow JA, Malapit CA.   +5 more
europepmc   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, Volume 121, Issue 4, Page 870-882, April 2026.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source

Novel 1-(2-Aryl-2-adamantyl)piperazine Derivatives Exhibit In Vitro Anticancer Activity Across Various Human Cancer Cell Lines, with Selective Efficacy Against Melanoma. [PDF]

Medicina (Kaunas)
Papapostolou I, Sereti E, Chatira S, Sakellaridis N, Fytas G, Zoidis G, Dimas K.   +6 more
europepmc   +1 more source