Results 161 to 170 of about 37,689 (286)

The toxicology and characteristics of fatal new psychoactive stimulant and hallucinogen-related poisonings in Australia, 2000-2025. [PDF]

Drug Alcohol Depend Rep
Darke S, Duflou J, Farrell M, Lappin J, Peacock A.   +4 more
europepmc   +1 more source

Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada

Addiction, Volume 121, Issue 6, Page 1530-1540, June 2026.
Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie, Ria Garg, Pamela Leece, Gillian Kolla, Elaine Hyshka, Mina Tadrous, Tara Gomes   +6 more
wiley   +1 more source

Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression. [PDF]

Nat Prod Bioprospect
Zha Z, He D, Song J, Guan Z, Han J, Liu C, Wang X, Zhu Y, Zhu H, Ye W, Li Q, Zhang Y, Zhou Y.   +12 more
europepmc   +1 more source

Histopathological Assessment of Precision‐Cut Kidney Slices: A Live Human Tissue‐Based Model of Renal Fibrosis

APMIS, Volume 134, Issue 6, June 2026.
ABSTRACT Chronic kidney disease (CKD) is characterized by a progressive decline of renal function. A major challenge in CKD drug development is the low success rate of drug candidates, with fewer than 10% of drugs entering Phase I clinical trials demonstrating clinical benefit.
Andreas Riishede, Camilla Merrild, Seulgi Hyun, Mia G. Madsen, Anna K. Keller, Henricus A. M. Mutsaers, Rikke Nørregaard, Lene N. Nejsum   +7 more
wiley   +1 more source

Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]

Chembiochem
He M, Thomson CM, Thompson D, Kuodis V, Smith TK, Dall'Angelo S, O'Hagan D.   +6 more
europepmc   +1 more source

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, Volume 293, Issue 12, Page 3528-3544, June 2026.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry. [PDF]

ChemistryOpen
Ten A, Koizhaiganova R, Bissenbay D, Tursynova B, Zhaxibayeva Z, Yu V.   +5 more
europepmc   +1 more source

Mobile Carrier Structure for Facilitated CO2 Transport in Mixed Ionic Liquid Membrane Composed of 1‐Ethyl‐3‐Methylimidazolium Acetate and Diamine‐Functionalized Ionic Liquids

ChemSusChem, Volume 19, Issue 10, 27 May 2026.
Mixed ionic liquid membranes combining 1 ethyl‐3‐methylimidazolium acetate with diamine‐functionalized ionic liquids enable facilitated CO2 transport for membrane based direct air capture. Tuning diamine terminal groups and spacer length establishes an optimal range in CO2 solubility that enhances CO2 permeability, and one hydroxyethyl terminal group ...
Yu Nagai Kanasaki, Yuki Kohno, Takashi Makino   +2 more
wiley   +1 more source

Structural Exploitation of Cinnarizine Identified Novel Drug-Like Anthelmintic Agents Against <i>Angiostrongylus cantonensis</i>. [PDF]

ACS Infect Dis
Lemes BL, Siegl-Breno MA, Silva-Nunes MK, Lopes FB, Silva AS, Motta NEP, de Moraes J, Fernandes JPS.   +7 more
europepmc   +1 more source

Development of green purification process for piperazine-type drugs: a case study of quetiapine process development. [PDF]

RSC Adv
Huang W, Wang Y, Liu H, Li H, Yin Q.
europepmc   +1 more source