Results 121 to 130 of about 39,960 (300)

The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue [PDF]

In recent years, use of psychoactive synthetic stimulants has grown rapidly. 5-(2-Aminopropyl)indole (5-IT) is a synthetic drug associated with a number of fatalities, that appears to be one of the newest 3,4-methylenedioxymethamphetamine (MDMA ...
Aarde, Aarde, Aarde, Abreu, Banks, Baumann, Baumann, Baumann, Baumann, Baumann, Baumann, Blough, Bossong, Bowen, Boyer, Bruce E. Blough, Brunt, Brunt, Bäckberg, Cerletti, Coppola, Creehan, Elliott, Eshleman, European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Fantegrossi, Fantegrossi, Fantegrossi, Filip, Fischman, German, Glennon, Green, Herraiz, Hill, Howell, Iversen, John S. Partilla, Julie A. Marusich, Kateland R. Antonazzo, López-Arnau, Ma, Marusich, Marusich, Michael H. Baumann, Miotto, Montgomery, National Research Council Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research, Negus, Negus, Nelson, Pierce V. Kavanagh, Reith, Rosenbaum, Rothman, Rothman, Rothman, Rothman, Scott, Seetohul, Shanks, Silins, Simmler, Simmler, Simon D. Brandt, Sitte, Troxler, U.S. Environmental Protection Agency (U.S. EPA), U.S. Environmental Protection Agency (U.S. EPA), United Nations Office on Drugs and Crime (UNODC), Watterson, Watterson, Wee, Wise, Woolverton, Yarosh   +78 more
core   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors [PDF]

, 2013
Please cite as follows: Chakravorty, S. et al. 2014. Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors.
Chakravorty, Santanu, Fang, Zhizhou, Hodson, Luke E., Klein, Hanna F., Pelly, Stephen C., Rabillier, Matthias, Rauh, Daniel, Richters, Andre, Van Otterlo, Willem A. L.   +8 more
core  

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, EarlyView.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 275-281, March/April 2025.
We present an original proof‐of‐concept methodology to probe radical generation from allergens in contact with photoexposed skin, using electron paramagnetic resonance and spin trapping in a reconstructed human epidermis model mimicking real‐life exposure scenarios.
Yannick Port‐Lougarre, Guillaume Voegeli, Bertrand Vileno, Elena Giménez‐Arnau   +3 more
wiley   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

Direct Mechanoorganocatalysis via Surface Functionalization of Milling Reactors With Amine Functions

ChemistryEurope, Volume 4, Issue 5, May 2026.
Surface functionalization of milling jars in epoxy resin furnished reactive milling jars, able to perform direct mechanoorganocatalysis with high efficiency, recyclability, and simplified purification. This proof of concept was applied successfully to base‐catalyzed Knoevenagel condensation and multicomponent reactions.
Joao Tanepau, Maxime Provost, Marie Gressier, Marie‐Joëlle Menu, Sandrine Duluard, Frédéric Lamaty, Julien Pinaud, Xavier Bantreil   +7 more
wiley   +1 more source

Triple Matrix Confinement‐Induced Ultrabright Afterglow From Carbon Dots With Multivariate Responsive Afterglow Colors for Advanced Dynamic Information Encryption

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
A novel carbon dots material (BUL‐CDs) with an initial afterglow brightness (406 cd m−2) far exceeding that of other afterglow luminescent materials was developed. Furthermore, the BUL‐CDs exhibited time‐dependent afterglow colors, excitation‐dependent afterglow colors, and thermochromic afterglow in response to triplet variables.
Yupeng Liu, Yiming Hao, Yi Li, Xiaofan Xia, Xichang Ou, Xue Wu, Jun Wu, Ruifeng Zheng, Dongbo Guo, Shi Chen, Jing Li, Jinyang Zhu, Qijun Li, Songnan Qu   +13 more
wiley   +2 more sources

In Vivo Measurement of UVA Protection Factor (ISO 24442:2011) Across 38 Different SPF 50 and SPF 50+ Sunscreens Reveals High Heterogeneity and Limitations in the Level of Protection

Photodermatology, Photoimmunology &Photomedicine, Volume 42, Issue 3, May 2026.
ABSTRACT Background/Purpose The UVB and UVA components of terrestrial solar ultraviolet radiation (UVR) cause acute and chronic damage to skin. These adverse effects can be reduced by sunscreen application. The sun protection factor (SPF) is primarily a measure of UVB protection against erythema and does not quantify protection from UVA, which is the ...
Antony Young, Caroline Tricaud, Françoise Bernerd, Yipin Yuan, Pascale Renoux, Marion Sensenbrenner, Ann‐Laure Demessant, Caroline Le Floc'h, Martin Josso, Philippe Andres   +9 more
wiley   +1 more source

Synthesis, Dynamic NMR Characterization, and XRD Study of 2,4-Difluorobenzoyl-Substituted Piperazines

Chemistry
Five different 2,4-difluorobenzamide derivatives were synthesized and fully characterized by 1H/13C/19F/2D NMR spectroscopy using DMSO-d6 as solvent and MS.
Martin Köckerling, Constantin Mamat
doaj   +1 more source