Results 111 to 120 of about 37,689 (286)

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Lithiation/trapping of N-Boc piperazines and synthesis of the (–)-sparteine surrogate [PDF]

, 2014
This thesis describes some novel aspects of the s-BuLi mediated lithiation/trapping of N-Boc heterocycles, including a systematic investigation into the lithiation/trapping of N-Boc piperazines.
Firth, James D
core  

Development of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material

Egyptian Journal of Forensic Sciences, 2014
Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives.
Yacine Boumrah, Martine Rosset, Yannick Lecompte, Sabrina Bouanani, Kamel Khimeche, Abdellah Dahmani   +5 more
doaj   +1 more source

On the Assembly of Actin Polymerization‐Powered Motors

Macromolecular Rapid Communications, EarlyView.
Actin polymerization‐powered motors have the highest speed when the actin recruiting‐polymerizing proteins are immobilized in polymer brushes on their surface. These motors orbit around larger tracer particles at pH above the isoelectric point of ActA but dock onto the tracer particles’ surface at lower pH. ABSTRACT Nano‐ and micromotors are a class of
Miguel A. Ramos Docampo, Cathrine Abild Meyer, Brigitte Städler   +2 more
wiley   +1 more source

Reactions between Grignard reagents and heterocyclic N-oxides: Stereoselective synthesis of substituted pyridines, piperidines, and piperazines

, 2011
In this perspective we discuss the recent developments of stereoselective synthesis of substituted pyridines, piperidines, and piperazines from cheap and commercially readily available starting materials.
Roger Olsson, Fredrik Almqvist, Olsson, Roger, Almqvist, Fredrik,, Hans Andersson, Andersson, Hans,   +5 more
core   +1 more source

Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives

Journal of Chemistry, 2013
A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives ...
Yuh-Wen Ho, Maw Cherng Suen
doaj   +1 more source

Revisiting the Association Between Calcium Channel Blockers and Parkinson's Disease in the E3N Cohort

Movement Disorders, EarlyView.
Abstract Background Previous studies on calcium channel blockers (CCBs) and Parkinson's disease (PD) risk reached conflicting conclusions. Objectives We examined the relationship between CCBs and PD in the E3N cohort of French women followed for 15 years (2004–2018), while taking into account the potential for reverse causation.
Emilie Moutard, Agnès Fournier, Émeline Courtois, Fanny Artaud, Pascale Tubert‐Bitter, Emmanuel Roze, Ismaïl Ahmed, Anne C.M. Thiébaut, Alexis Elbaz, Thi Thu Ha Nguyen   +9 more
wiley   +1 more source

Cefdinir reprograms Gram‐positive bacteria to synergize with lysozyme against superbugs

mLife, EarlyView.
Abstract Multidrug‐resistant (MDR) bacteria pose a critical global health threat, urgently requiring solutions. Cefdinir, the highest‐selling third‐generation cephalosporin but one now facing clinical obsolescence due to escalating resistance, is conventionally classified as a nascent cell wall synthesis inhibitor.
Qi Zhang, Yang Yang, Shuqi Li, Zhao Liu, Chun‐Kit Lee, Chi‐Bun Ko, Qian Zhao   +6 more
wiley   +1 more source

Synthesis of [1,2,4]Triazolo[4,3-α]piperazines via Highly Reactive Chloromethyloxadiazoles

, 2016
A concise, modular approach for the synthesis of [1,2,4]triazolo[4,3-α]piperazines via condensation of highly reactive chloromethyloxadiazoles with ethylenediamines is described.
Karl Hansen (2221882), Michele Kubryk (1660960), Joseph D. Armstrong (2366482), Jaume Balsells (1458115), Lisa DiMichele (2023210), Jinchu Liu (2169022)   +5 more
core   +1 more source

“High-Throughput” Evaluation of Polymer-Supported Triazolic Appendages for Metallic Cations Extraction

Metals, 2015
The aim of this work was to find and use a low-cost high-throughput method for a quick primary evaluation of several metal extraction by substituted piperazines appendages as chelatants grafted onto Merrifield polymer using click-chemistry by the ...
Riadh Slimi, Christian Girard
doaj   +1 more source