Results 91 to 100 of about 15,176 (256)

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source

Synthesis of N‑Pyrrolyl(furanyl)-Substituted Piperazines, 1,4-Dizepanes, and 1,4-Diazocanes

, 2019
The synthetic potential of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one toward the catalyst-free synthesis of N-pyrrolyl­(furanyl)-piperazines, 1,4-diazepanes, and 1,4-diazocanes through a telescoped protocol is reported. This three-component one-pot
Lucimara L. Zachow, Clarissa P. Frizzo (1457206), Marcos A. P. Martins, Nilo Zanatta, Helio G. Bonacorso (1457209), Marcos A. P. Martins (1457212), Mateus Mittersteiner (6899375), Clarissa P. Frizzo, Mateus Mittersteiner, Lucimara L. Zachow (3341348), Valquiria P. Andrade, Valquiria P. Andrade (6899378), Helio G. Bonacorso, Nilo Zanatta (1457224)   +13 more
core   +3 more sources

Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue

Journal of Saudi Chemical Society, 2010
In the present work, carbonyl pyridoquinolones 8–33 were synthesized and their ability to inhibit gram-positive stains Bacillus subtilis and Staphylococcus aureus, gram-negative stains Escherichia coli and Pseudomonas aeruginosa, and fungi Candida ...
Navin B. Patel, Jaymin C. Patel, Sandip H. Modi   +2 more
doaj   +1 more source

Synthesis And Antitubercular Activity Of 1,2,4-Trisubstitued Piperazines

, 2016
Parallel solid phase synthesis offers a unique opportunity for the synthesis and screening of large numbers of compounds and significantly enhances the prospect of finding new leads.
Rohde, Kyle H., Nefzi, Adel, Michaels, Heather A.   +2 more
core   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Rich‐Electronic Interface Promoting Hydrogen‐Bond Reversible Formation for Ultra‐Stable and Energy‐Efficient Catalytic CO2 Capture

Carbon Energy, EarlyView.
Bridging micro–macro scales, a biomass‐derived Ni@C interface creates electron‐rich sites and hydrogen‐bond proton‐relay pathways, tuning interfacial charge and reversible hydrogen bond to enhance carbon capture capacity. Verified by in situ spectroscopy, multi‐scale simulations, and long‐term industrial testing, this system enables low‐temperature and
Yuetong Zhao, Kun Zhao, Canyu Hu, Xinyu Guo, Pengyu Du, Dong Xu, Weiping Zhang, Liqiang Qi, Pan Zhang, Chenghua Sun, Bingyuan Zeng, Liwen Li, Shuming Du, Lemeng Wang, Dong Fu   +14 more
wiley   +1 more source

Stereospecific Ring Opening and Cycloisomerization of Aziridines with Propargylamines: Synthesis of Functionalized Piperazines and Tetrahydropyrazines

, 2018
Stereospecific Cu-catalyzed nucleophilic ring opening of N-sulfonylaziridines with propargylamines and subsequent hydroamination afford piperazines, which leads to double-bond isomerization to furnish tetrahydro­pyrazines. Optically active aziridines can
Tharmalingam Punniyamurthy (1490761), Bijay Ketan Das (5519159), Sourav Pradhan (3814492)   +2 more
core   +1 more source

Iso‐Tellurazole N‐Oxides Assemble Adaptively Folded Macrocyclic Dodecamers

Chemistry – A European Journal, EarlyView.
Te…O Chalcogen bonding links twelve molecules into a ring that wraps itself around molecular guests. ABSTRACT Self‐assembled macrocyclic dodecamers were found in the crystals of new pseudo‐polymorphs of iso‐tellurazole N‐oxides. These structures are formed by molecules connected by NTe…O chalcogen bonds and are folded in a pattern that defines 89–153 ...
Jin Z. Wang, Phillip MacDougall, Mich W. Zeng, James F. Britten, Ignacio Vargas‐Baca   +4 more
wiley   +1 more source

Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives

Journal of Chemistry, 2013
A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives ...
Yuh-Wen Ho, Maw Cherng Suen
doaj   +1 more source

Development of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material

Egyptian Journal of Forensic Sciences, 2014
Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives.
Yacine Boumrah, Martine Rosset, Yannick Lecompte, Sabrina Bouanani, Kamel Khimeche, Abdellah Dahmani   +5 more
doaj   +1 more source