Results 81 to 90 of about 15,176 (256)
, 2016 A new method for the synthesis of enantiopure α-substituted piperazines via direct functionalization of the intact piperazine ring is described. The approach utilizes the asymmetric lithiation–substitution of an α-methylbenzyl-functionalized N-Boc ...
James D. Firth (1429162) +2 more
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Molecules, 2020 We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group ...
Dana Němečková +4 more
doaj +1 more source
Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides
, 2016 A facile method has been developed for the synthesis of chiral piperazines through Ir-catalyzed hydrogenation of pyrazines activated by alkyl halides, giving a wide range of chiral piperazines including 3-substituted as well as 2,3- and 3,5-disubstituted
Wen-Xue Huang (1626910) +11 more
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SC-XRD diffraction images of stereo-defined piperazines (1/2)
, 2017 <p>Structures of two piperazines in the publication: Suarez-Pantiga, S.; Colas, K.; Johansson, M. J.; Mendoza, A.* "Scalable synthesis of piperazines enabled by visible light irradiation and aluminum organometallics" <br> Angew. Chem. Int. Ed.
Colas, Kilian +7 more
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, 2011 Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass ...
梁振 +7 more
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, 1992 Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya, Sagar-470 003 Manuscript received 27 May 1991, revised 21 November 1991, accepted 6 January 1992 Synthesis and Antimicrobial Activity of N-[α-(Phenoxy/Substituted-phenoxy)acetyl/propionyl ...
SAVITRI D. SRIVASTAVA, SUNITA CHAURASIA
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Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines [PDF]
, 2017 Designer drugs are some of the most commonly abused substances in the world. They are synthesized through slight chemical modifications of existing substances, evading the law while maintaining the desired effects of the pharmaceutical or illicit ...
Ward, Jessamyn
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British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Opportunities and challenges for direct C–H functionalization of piperazines
Beilstein Journal of Organic Chemistry, 2016 Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend ...
Zhishi Ye, Kristen E. Gettys, Mingji Dai
doaj +1 more source
A Practical Synthesis of Differentially Protected 2-(Hydroxymethyl)piperazines
, 2016 An efficient and scalable synthesis of three differentially protected 2-(hydroxymethyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride.
Hongwu Gao (2471113) +1 more
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