Results 81 to 90 of about 37,689 (286)
Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium
Angewandte Chemie, EarlyView.Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner +2 more
wiley +1 more source
Designer drugs: aspectos analíticos e biológicos
Química Nova, 2012 In the recent years, analytical toxicologists have been facing difficulties in detecting designer drugs due to the chemical modifications on the existing structures and the speed in which they are released into the market, requiring the development and ...
Rachel Bulcão +7 more
doaj +1 more source
De Novo Assembly of Highly Substituted Morpholines and Piperazines
Organic Letters, 2017 The morpholine and piperazine with their remarkable physical and biochemical properties are popular heterocycles in organic and medicinal chemistry used in rational property design.
P. Patil +4 more
semanticscholar +1 more source
A General, Enantioselective Synthesis of Protected Morpholines and Piperazines
, 2016 A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N′-protected piperazines from a common ...
Matthew C. O’Reilly (1368825) +1 more
core +1 more source
Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines [PDF]
, 2017 Designer drugs are some of the most commonly abused substances in the world. They are synthesized through slight chemical modifications of existing substances, evading the law while maintaining the desired effects of the pharmaceutical or illicit ...
Ward, Jessamyn
core
, 2016 The synthesis of enantiomerically pure cis- and trans-2-phenyl-3-(trifluoromethyl)piperazines is described. It involved, as the key step, a diastereoselective nucleophilic addition of the Ruppert–Prakash reagent (TMSCF3) to α-amino sulfinylimines ...
Santos Fustero (1330944) +5 more
core +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
, 2016 A new method for the synthesis of enantiopure α-substituted piperazines via direct functionalization of the intact piperazine ring is described. The approach utilizes the asymmetric lithiation–substitution of an α-methylbenzyl-functionalized N-Boc ...
James D. Firth (1429162) +2 more
core +1 more source
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley +1 more source
, 2021 Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic ...
Tania De Koning-Ward (13096974) +12 more
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