Results 61 to 70 of about 15,176 (256)

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources

Synthesis of novel antibacterial and antifungal dithiocarbamate-containing piperazine derivatives via re-engineering multicomponent approach

Heliyon, 2022
A metal-free multicomponent synthetic route for the diverse preparation of dithiocarbamate-containing piperazine derivatives was developed through the C–N bond cleavage of DABCO ring.
Azim Ziyaei Halimehjani, Faezeh Dehghan, Vida Tafakori, Elaheh Amini, Seyyed Emad Hooshmand, Yazdanbkhsh Lotfi Nosood   +5 more
doaj   +1 more source

Precise Control of Charge–Structure Coupling in Polyamide Membranes for Mono‐ and Divalent Ion Separation

Advanced Science, EarlyView.
A zwitterionic copolymer, Poly(2‐methacryloyloxyethyl phosphorylcholine‐co‐2‐aminoethyl methacrylate hydrochloride) (P(MPC‐co‐AEMA)) copolymers, with tunable MPC/AEMA ratios, is grafted onto the polyamide (PA) selective layer via secondary interfacial polymerization. Balancing reactive anchoring segments (AEMA) and zwitterionic segments (MPC) regulated
Shaofan Duan, Shuai Jiang, Feidong Yang, Yuxuan Feng, Yongxuan Shi, Pengfei Zhang, Mengyang Hu, Yuqing Lin, Tae Hoon Lee, Kecheng Guan, Keizo Nakagawa, Tomohisa Yoshioka, Hideto Matsuyama, Eiji Kamio   +13 more
wiley   +1 more source

Engineering Rapid Payload Release Rate in 1,6‐Elimination Processes of Self‐Immolative Linkers

Angewandte Chemie, EarlyView.
The payload release rate of self‐immolative linkers was greatly improved through stabilization of an intermediate carbocation, thereby achieving an up to 10 000‐fold improvement in rate constant. Furthermore, lipophilicity was identified as another factor that affects the release rate. This new strategy is applicable to different payloads and different
Albert Marten Schulte, Gülbahar Bozan, Francesca Amoroso, Bart Cornelissen, Wiktor Szymanski   +4 more
wiley   +2 more sources

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

A General, Enantioselective Synthesis of Protected Morpholines and Piperazines

, 2016
A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N′-protected piperazines from a common ...
Matthew C. O’Reilly (1368825), Craig W. Lindsley (203380)   +1 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Piperazine Abuse and Psychosis: A Systematic Review of the Literature

Psychiatry International
Background: Piperazines, synthetic compounds known for their stimulant and hallucinogenic effects, have gained prominence among novel psychoactive substances (NPS) and are frequently associated with adverse psychiatric outcomes, including psychosis ...
Alessio Mosca, Stefania Chiappini, Andrea Miuli, Gianluca Mancusi, Clara Cavallotto, John M. Corkery, Livia Miotti, Mauro Pettorruso, Giovanni Martinotti, Fabrizio Schifano   +9 more
doaj   +1 more source

4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues. [PDF]

PLoS ONE, 2017
Our ability to use ionizing radiation as an energy source, as a therapeutic agent, and, unfortunately, as a weapon, has evolved tremendously over the past 120 years, yet our tool box to handle the consequences of accidental and unwanted radiation ...
Ewa D Micewicz, Kwanghee Kim, Keisuke S Iwamoto, Josephine A Ratikan, Genhong Cheng, Gayle M Boxx, Robert D Damoiseaux, Julian P Whitelegge, Piotr Ruchala, Christine Nguyen, Prabhat Purbey, Joseph Loo, Gang Deng, Michael E Jung, James W Sayre, Andrew J Norris, Dörthe Schaue, William H McBride   +17 more
doaj   +1 more source

Decoding Interfacial Polymerization Through Steady Amine Delivery and Real‐Time QCM‐D Monitoring

Advanced Science, EarlyView.
We combine steady amine delivery with in situ quartz crystal microbalance with dissipation to track interfacial polymerization in real time. The platform resolves three kinetic regimes: pre‐gelation oligomerization, post‐gelation aggregation and network growth, and diffusion‐limited film evolution.
Yu Fang, Yu‐Ren Xue, Cheng‐Ye Zhu, Hong‐Qing Liang, Zhi‐Kang Xu   +4 more
wiley   +1 more source