Results 101 to 110 of about 39,960 (300)

First Reported Fatalities Associated with the 'Research Chemical' 2-Methoxydiphenidine [PDF]

2-Methoxydiphenidine, i.e. 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine, also known as 'MXP' or '2-MeO-diphenidine' (or 2-MXP), has been available as a 'research chemical' since 2013 as a purported alternative to the 'dissociative anesthetics ...
Brandt, SD, Elliott, SP, Kavanagh, PV, Morris, H, Wallach, J   +4 more
core   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

An exploratory study of information sources and key findings on UK cocaine-related deaths. [PDF]

, 2017
Cocaine-related deaths have increased since the early 1990s in Europe, including the UK. Being multi-factorial, they are difficult to define, detect and record.
Arendt M, Christine Goodair, Cregler LL, Fabrizio Schifano, Gray JD, Hugh Claridge, John M Corkery, LGC, Parker RB, Pawlik E, Schifano F, Winstock A   +11 more
core   +3 more sources

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives

Journal of Chemistry, 2013
A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives ...
Yuh-Wen Ho, Maw Cherng Suen
doaj   +1 more source

Development of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material

Egyptian Journal of Forensic Sciences, 2014
Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives.
Yacine Boumrah, Martine Rosset, Yannick Lecompte, Sabrina Bouanani, Kamel Khimeche, Abdellah Dahmani   +5 more
doaj   +1 more source

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes.2. Syntheses and biological activities of 1,4-dialkyl-,1,4-dibenzyl and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1' H-imidazol-2'yl)piperazines and isosteric analogues of imidazoline [PDF]

, 1999
International ...
Dive, G., Godfroid, J. J., Guardiola-Lemaitre, B., Huet, J., Ktorza, Alain, Lamouri, A., Le Bihan, G., Lidy, S., Manechez, D., Pele-Tounian, A., Pfeiffer, B., Pénicaud, Luc, Renard, P., Rondu, F., Touboul, E., Wang, X.   +15 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

MC19 (M = B, Si, Al and Ga) fullerenes: Adsorption mechanisms of 1,4-diformylpiperazine

Adsorption Science & Technology, 2018
Fullerenes and piperazines have been investigated, particularly, in the field of nanoscience and medicinal chemistry. In the present research, besides discussing structural and electronic properties, the most probable interaction mechanisms between C20 ...
Özgür Alver, Cemal Parlak, Ponnadurai Ramasami   +2 more
doaj   +1 more source

Supramolecular Complexation of \u3cem\u3eN\u3c/em\u3e-Alkyl- and \u3cem\u3eN\u3c/em\u3e,\u3cem\u3eN\u3c/em\u3e′-Dialkylpiperazines with Cucurbit[6]uril in Aqueous Solution and in the Solid State [PDF]

, 2009
Water seeds: Complex stoichiometry/composition and degree of oligomerization (oligomeric supramolecular complex formation) of cucurbit[6]uril (CB[6]) with N-alkyl- and N,N′-dialkylpiperazine were investigated in aqueous solutions by means of isothermal ...
Inoue, Yoshihisa, Kim, Kimoon, Ko, Young Ho, Lindeman, Sergey V., Mori, Tadashi, Rathore, Rajendra, Rekharsky, Mikhail V., Sato, Akihiro, Selvapalam, Narayanan, Shiba, Kouhei, Shiro, Motoo, Yamamura, Hatsuo   +11 more
core   +1 more source