Results 11 to 20 of about 15,176 (256)
Stereoselective electrochemical intramolecular imino-pinacol reaction: a straightforward entry to enantiopure piperazines [PDF]
Beilstein Journal of Organic ChemistryThe stereoselective electroreductive intramolecular coupling of chiral diimines of aromatic aldehydes with trans-1,2-diaminocyclohexane for the synthesis of enantiopure tetrasubstituted piperazines has been investigated by an electrochemical approach ...
Margherita Gazzotti +5 more
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Recent Advances in the Synthesis of Piperazines: Focus on C–H Functionalization
Organics, 2021 Piperazine ranks as the third most common nitrogen heterocycle in drug discovery, and it is the key component of several blockbuster drugs, such as Imatinib (also marketed as Gleevec) or Sildenafil, sold as Viagra.
Carolina Durand, Michal Szostak
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Molecules, 2022 Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological ...
Freeha Hafeez +8 more
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Iridium-Catalyzed Regio- and Diastereoselective Synthesis of C‑Substituted Piperazines [PDF]
, 2023 Piperazine rings are essential motifs frequently found in commercial drugs. However, synthetic methodologies are mainly limited to N-substituted piperazines, preventing structural diversity.
Ana M. Geer (2095597) +27 more
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Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova +4 more
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THE PREPARATION OF PIPERAZINE. [PDF]
Journal of the American Chemical Society, 1918 n ...
Pratt, David S., Young, Charles O.
openaire +2 more sources
Lithiation/trapping of N-Boc piperazines and synthesis of the (–)-sparteine surrogate [PDF]
, 2014 This thesis describes some novel aspects of the s-BuLi mediated lithiation/trapping of N-Boc heterocycles, including a systematic investigation into the lithiation/trapping of N-Boc piperazines.
Firth, James D
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New psychoactive substances and the risks of consumption in children and adolescents [PDF]
Romanian Journal of Pediatrics, 2019 According to the definition established by the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) a “new psychoactive substance is considered any narcotic or psychotropic substance in pure form or in preparations, which is not controlled by
Viorela Nitescu
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Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence
Molecules, 2021 Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 The structures are reported for five salts formed by reactions between N-(4-fluorophenyl)piperazine and aromatic acids. In 4-(4-fluorophenyl)piperazin-1-ium 2-fluorobenzoate monohydrate, C10H14FN2+·C7H4FO2−·H2O, (I), the components are linked by a ...
Chayanna Harish Chinthal +4 more
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