Results 11 to 20 of about 39,960 (300)
Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents [PDF]
Journal of Medicinal Chemistry, 2017 The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents.
Nishad Thamban Chandrika +5 more
openaire +3 more sources
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Four human (h) carbonic anhydrase isoforms (CA, EC 4.2.1.1), hCA I, II, IV, and VII, were investigated for their activation profile with piperazines belonging to various classes, such as N-aryl-, N-alkyl-, N-acyl-piperazines as well as 2,4-disubstituted ...
Andrea Angeli +4 more
doaj +2 more sources
Opportunities and challenges for direct C–H functionalization of piperazines
Beilstein Journal of Organic Chemistry, 2016 Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend ...
Zhishi Ye, Kristen E. Gettys, Mingji Dai
doaj +2 more sources
ACS Catalysis, 2022 We report a photocatalyzed epimerization of morpholines and piperazines that proceeds by reversible hydrogen atom transfer (HAT) and provides an efficient strategy for editing the stereochemical configurations of these saturated nitrogen heterocycles ...
Zican Shen +4 more
semanticscholar +1 more source
Biomedicines, 2023 Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish +10 more
doaj +1 more source
Crystals, 2022 The crystal structures of three salts, namely N-(4-methoxyphenyl)piperazin-1-ium ethoxybenzoate monohydrate (I), N-(4-methoxyphenyl)piperazin-1-ium methoxybenzoate monohydrate (II) and N-(4-methoxyphenyl)piperazin-1-ium hydroxybenzoate monohydrate (III),
Prabhakar Priyanka +8 more
doaj +1 more source
Recent trends in analytical methods to determine new psychoactive substances in hair [PDF]
, 2017 New Psychoactive Substances (NPS) belong to several chemical classes, including phenethylamines, piperazines, synthetic cathinones and synthetic cannabinoids.
García Algar, Oscar +4 more
core +1 more source
Chlorocobalt complexes with pyridylethyl-derived diazacycloalkanes
Acta Crystallographica Section E: Crystallographic Communications, 2022 Syntheses are described for the blue/purple complexes of cobalt(II) chloride with the tetradentate ligands 1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Ppz), 1,4-bis[2-(pyridin-2-yl)ethyl]homopiperazine (Phpz), trans-2,5-dimethyl-1,4-bis[2-(pyridin-2-yl ...
Anthony W. Addison +7 more
doaj +1 more source
An index of fatal toxicity for new psychoactive substances [PDF]
, 2018 The final, definitive version of this paper has been published in Journal of Psychopharmacology, February 2018, published by SAGE Publishing, All rights reserved.An index of fatal toxicity for new psychoactive substances has been developed based solely ...
Corkery, John, King, L.A.
core +2 more sources
Organic Letters, 2020 Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl ...
Robin Gueret +5 more
semanticscholar +1 more source