Results 31 to 40 of about 37,689 (286)

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +1 more source

Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions: supramolecular assembly in zero, one, two and three dimensions

Acta Crystallographica Section E: Crystallographic Communications, 2020
Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. In the isostructural 4-chlorobenzoate and 4-bromobenzoate salts, C11H17N2O+·C7H4ClO2− (I) and C11H17N2O+·C7H4BrO2− (II), and the
Chayanna Harish Chinthal, Channappa N. Kavitha, Hemmige S. Yathirajan, Sabine Foro, Ravindranath S. Rathore, Christopher Glidewell   +5 more
doaj   +1 more source

Hydrogen-Bonded Chain of Rings Motif in N-(4-Methoxyphenyl)piperazin-1-ium Salts with Benzoate Anions: Supramolecular Assemblies and Their Energy Frameworks

Crystals, 2022
The crystal structures of three salts, namely N-(4-methoxyphenyl)piperazin-1-ium ethoxybenzoate monohydrate (I), N-(4-methoxyphenyl)piperazin-1-ium methoxybenzoate monohydrate (II) and N-(4-methoxyphenyl)piperazin-1-ium hydroxybenzoate monohydrate (III),
Prabhakar Priyanka, Bidarur K. Jayanna, Thayamma R. Divakara, Gejjalagere P. Suresha, Vinaya, Yeriyur B. Basavaraju, Hemmige S. Yathirajan, Sean R. Parkin, Lilianna Chęcińska   +8 more
doaj   +1 more source

Chlorocobalt complexes with pyridylethyl-derived diazacycloalkanes

Acta Crystallographica Section E: Crystallographic Communications, 2022
Syntheses are described for the blue/purple complexes of cobalt(II) chloride with the tetradentate ligands 1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Ppz), 1,4-bis[2-(pyridin-2-yl)ethyl]homopiperazine (Phpz), trans-2,5-dimethyl-1,4-bis[2-(pyridin-2-yl ...
Anthony W. Addison, Stephen J. Jaworski, Jerry P. Jasinski, Mark M. Turnbull, Fan Xiao, Matthias Zeller, Molly A. O'Connor, Elizabeth A. Brayman   +7 more
doaj   +1 more source

Visible-Light-Driven CarboxyLic Amine Protocol (CLAP) for the Synthesis of 2-Substituted Piperazines under Batch and Flow Conditions.

Organic Letters, 2020
Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl ...
Robin Gueret, Lydie Pélinski, Till Bousquet, M. Sauthier, V. Ferey, A. Bigot   +5 more
semanticscholar   +1 more source

A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines

Molecules, 2022
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five ...
Srinivas Chamakuri, Sunny Ann Tang, Kevin A. Tran, Shiva Krishna Reddy Guduru, Peter K. Bolin, Kevin R. MacKenzie, Damian W. Young   +6 more
doaj   +1 more source

Crystal structure of 2-(4-methylpiperazin-1-yl)quinoline-3-carbaldehyde

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C15H17N3O, the aldehyde group is twisted relative to the quinoline group by17.6 (2)° due to the presence of a bulky piperazinyl group in the ortho position.
R Nivedita Desai, S Sreenivasa, S. Naveen, N. K. Lokanath, P. A. Suchetan, D. B. Aruna Kumar   +5 more
doaj   +1 more source

Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway.

Organic and biomolecular chemistry, 2020
The hancockiamides are an unusual new family of N-cinnamoylated piperazines from the Australian soil fungus Aspergillus hancockii. Genomic analyses of A.
Hang Li, Alastair E Lacey, Si Shu, J. Kalaitzis, Daniel Vuong, A. Crombie, Jinyu Hu, Cameron L. M. Gilchrist, E. Lacey, Andrew M. Piggott, Y. Chooi   +10 more
semanticscholar   +1 more source

Piperazine [PDF]

The American Journal of the Medical Sciences, 1894
n ...
openaire   +1 more source

Piperazine Hepatitis

Gastroenterology, 1976
The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver.
A N, Hamlyn, J S, Morris, I, Sarkany, S, Sherlock   +3 more
openaire   +2 more sources