Results 21 to 30 of about 37,689 (286)

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Four human (h) carbonic anhydrase isoforms (CA, EC 4.2.1.1), hCA I, II, IV, and VII, were investigated for their activation profile with piperazines belonging to various classes, such as N-aryl-, N-alkyl-, N-acyl-piperazines as well as 2,4-disubstituted ...
Andrea Angeli, Niccolò Chiaramonte, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran   +4 more
doaj   +2 more sources

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

Organic Letters, 2016
We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction.
Thomas D. Montgomery, V. Rawal
semanticscholar   +2 more sources

Efficient one-pot synthesis of enantiomerically pure N-protected-α-substituted piperazines from readily available α-amino acids

, 2018
A new pathway towards enantiomerically pure 3-substituted piperazines, bearing a benzyl protecting group, has been developed in good overall yields (83–92%), starting from commercially available N-protected amino acids.
Mouhamad Jida, S. Ballet
semanticscholar   +2 more sources

Ultrasound-Assisted Synthesis and In Silico Modeling of Methanesulfonyl-Piperazine-Based Dithiocarbamates as Potential Anticancer, Thrombolytic, and Hemolytic Structural Motifs

Molecules, 2022
Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological ...
Freeha Hafeez, Ameer Fawad Zahoor, Azhar Rasul, Asim Mansha, Razia Noreen, Zohaib Raza, Kulsoom Ghulam Ali, Ali Irfan, Gamal A. El-Hiti   +8 more
doaj   +1 more source

Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022
Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova, Aida Seitaliyeva, Elmira Satbayeva, Daniya Serdalieva, Talgat Nurgozhin   +4 more
doaj   +1 more source

New psychoactive substances and the risks of consumption in children and adolescents [PDF]

Romanian Journal of Pediatrics, 2019
According to the definition established by the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) a “new psychoactive substance is considered any narcotic or psychotropic substance in pure form or in preparations, which is not controlled by
Viorela Nitescu
doaj   +1 more source

Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence

Molecules, 2021
Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego, Ana G. Neo, Carlos F. Marcos   +2 more
doaj   +1 more source

Crystal structures of the recreational drug N-(4-methoxyphenyl)piperazine (MeOPP) and three of its salts

Acta Crystallographica Section E: Crystallographic Communications, 2020
Crystal structures are reported for N-(4-methoxyphenyl)piperazine (MeOPP), (I), and for its 3,5-dinitrobenzoate, 2,4,6-trinitrophenolate (picrate) and 4-aminobenzoate salts, (II)–(IV), the last of which crystallizes as a monohydrate. In MeOPP, C11H16N2O,
Haruvegowda Kiran Kumar, Hemmige S. Yathirajan, Chayanna Harish Chinthal, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source

THE PREPARATION OF PIPERAZINE. [PDF]

Journal of the American Chemical Society, 1918
n ...
Pratt, David S., Young, Charles O.
openaire   +2 more sources

The crystal structures of salts of N-(4-fluorophenyl)piperazine with four aromatic carboxylic acids and with picric acid

Acta Crystallographica Section E: Crystallographic Communications, 2020
The structures are reported for five salts formed by reactions between N-(4-fluorophenyl)piperazine and aromatic acids. In 4-(4-fluorophenyl)piperazin-1-ium 2-fluorobenzoate monohydrate, C10H14FN2+·C7H4FO2−·H2O, (I), the components are linked by a ...
Chayanna Harish Chinthal, Hemmige S. Yathirajan, Channappa N. Kavitha, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source