Results 21 to 30 of about 13,032 (188)

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +1 more source

Hydrogen-Bonded Chain of Rings Motif in N-(4-Methoxyphenyl)piperazin-1-ium Salts with Benzoate Anions: Supramolecular Assemblies and Their Energy Frameworks

Crystals, 2022
The crystal structures of three salts, namely N-(4-methoxyphenyl)piperazin-1-ium ethoxybenzoate monohydrate (I), N-(4-methoxyphenyl)piperazin-1-ium methoxybenzoate monohydrate (II) and N-(4-methoxyphenyl)piperazin-1-ium hydroxybenzoate monohydrate (III),
Prabhakar Priyanka, Bidarur K. Jayanna, Thayamma R. Divakara, Gejjalagere P. Suresha, Vinaya, Yeriyur B. Basavaraju, Hemmige S. Yathirajan, Sean R. Parkin, Lilianna Chęcińska   +8 more
doaj   +1 more source

Chlorocobalt complexes with pyridylethyl-derived diazacycloalkanes

Acta Crystallographica Section E: Crystallographic Communications, 2022
Syntheses are described for the blue/purple complexes of cobalt(II) chloride with the tetradentate ligands 1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Ppz), 1,4-bis[2-(pyridin-2-yl)ethyl]homopiperazine (Phpz), trans-2,5-dimethyl-1,4-bis[2-(pyridin-2-yl ...
Anthony W. Addison, Stephen J. Jaworski, Jerry P. Jasinski, Mark M. Turnbull, Fan Xiao, Matthias Zeller, Molly A. O'Connor, Elizabeth A. Brayman   +7 more
doaj   +1 more source

Piperazine Hepatitis

Gastroenterology, 1976
The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver.
A N, Hamlyn, J S, Morris, I, Sarkany, S, Sherlock   +3 more
openaire   +2 more sources

Synthesis and Molecular Structure of tert-Butyl 4-(2-tert-butoxy-2-oxoethyl)piperazine-1-carboxylate

Crystals, 2012
The crystal and molecular structure of tert-butyl 4-(2-tert-butoxy-2-oxoethyl)-piperazine-1-carboxylate is reported. The title compound crystallizes from a petroleum ether/ethyl acetate mixture in the monoclinic space group P 21/c with four molecules in ...
Martin Köckerling, Anke Flemming, Constantin Mamat   +2 more
doaj   +1 more source

A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines

Molecules, 2022
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five ...
Srinivas Chamakuri, Sunny Ann Tang, Kevin A. Tran, Shiva Krishna Reddy Guduru, Peter K. Bolin, Kevin R. MacKenzie, Damian W. Young   +6 more
doaj   +1 more source

Three 4-(4-fluorophenyl)piperazin-1-ium salts containing organic anions: supramolecular assembly in one, two and three dimensions

Acta Crystallographica Section E: Crystallographic Communications, 2020
Three salts containing the 4-(4-fluorophenyl)piperazin-1-ium cation have been prepared and structurally characterized. In 4-(4-fluorophenyl)piperazin-1-ium 2-hydroxy-3,5-dinitrobenzoate, C10H14FN2+·C7H3N2O7−, (I), the anion contains an intramolecular O—H.
Chayanna Harish Chinthal, Hemmige S. Yathirajan, Sreeramapura D. Archana, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source

Crystal structure of 2-(4-methylpiperazin-1-yl)quinoline-3-carbaldehyde

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C15H17N3O, the aldehyde group is twisted relative to the quinoline group by17.6 (2)° due to the presence of a bulky piperazinyl group in the ortho position.
R Nivedita Desai, S Sreenivasa, S. Naveen, N. K. Lokanath, P. A. Suchetan, D. B. Aruna Kumar   +5 more
doaj   +1 more source

Three closely related 1-[(1,3-benzodioxol-5-yl)methyl]-4-(halobenzoyl)piperazines: similar molecular structures but different intermolecular interactions

Acta Crystallographica Section E: Crystallographic Communications, 2019
In each of the compounds 1-[(1,3-benzodioxol-5-yl)methyl]-4-(3-fluorobenzoyl)piperazine, C19H19FN2O3 (I), 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,6-difluorobenzoyl)piperazine, C19H18F2N2O3 (II), and 1-[(1,3-benzodioxol-5-yl)methyl]-4-(2,4-dichlorobenzoyl ...
Ninganayaka Mahesha, Belakavadi K. Sagar, Hemmige S. Yathirajan, Tetsundo Furuya, Tomoyuki Haraguchi, Takashiro Akitsu, Christopher Glidewell   +6 more
doaj   +1 more source

Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly

Acta Crystallographica Section E: Crystallographic Communications, 2019
Six new 1-aroyl-4-(4-methoxyphenyl)piperazines have been prepared, using coupling reactions between benzoic acids and N-(4-methoxyphenyl)piperazine.
Haruvegowda Kiran Kumar, Hemmige S. Yathirajan, Belakavadi K. Sagar, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source