Results 191 to 200 of about 76,241 (267)

PIPERIDINE : A CORRECTION. [PDF]

The Lancet, 1898
F.W. Tunnicliffe, Otto Rosenheim
openaire   +1 more source

Covalent Peptide‐Based N‐Myc/Aurora‐A Inhibitors Bearing Sulfonyl Fluoride Warheads

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
N‐Myc‐derived peptidomimetics bearing aryl sulfonyl fluoride warheads were shown to act as effective N‐Myc/Aurora‐A PPI inhibitors, selectively labelling Aurora‐A in a recognition‐directed manner. ABSTRACT Orthosteric inhibition of the N‐Myc/Aurora‐A protein–protein interaction (PPI) represents a potential mechanism by which degradation of N‐Myc can be
Robert S. Dawber, Diana Gimenez, George W. Preston, Megan H. Wright, Richard Bayliss, Stuart L. Warriner, Andrew J. Wilson   +6 more
wiley   +1 more source

Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria. [PDF]

J Med Chem
Gahalawat S, Ray S, Zhang X, Deng X, Han Y, Chen Z, Lawong A, Shackleford DM, Katneni K, Chen G, Li P, Ng A, Zhong L, Hu M, McInerney M, Wang W, Saunders J, Collins D, Jayaseelan J, Noack CL, C Maity B, De N, Laleu B, Campbell SF, Phillips MA, Charman SA, Ready JM.   +26 more
europepmc   +1 more source

Renovating Neural Networks With Viral‐Mediated Gene Transfer From A Tissue Contacting Matrix Mimic

Small, Volume 22, Issue 17, 20 March 2026.
Fmoc‐DDIKVAV self‐assembling peptidemediated delivery of AAV‐BDNF significantly enhances neuroprotection in the striatum of a mouse model compared with AAV‐BDNF injection alone. This synergistic integration of biomaterial scaffolding and gene therapy holds substantial promise for slowing the progression of neurodegenerative diseases such as Huntington ...
Shiva Soltani Dehnavi, Negar Mahmoudi, Yi Wang, Samuel Cheeseman, Rita Ferreira, Ross D. Hannan, Leszek Lisowski, Vincent S. J. Craig, Niamh Moriarty, Clare L. Parish, Richard J. Williams, David R. Nisbet   +11 more
wiley   +1 more source

Piperidine-catalyzed synthesis of (<i>E</i>)-2-cyanoacrylamides: crystallographic, antiproliferative, and docking studies. [PDF]

RSC Adv
Serrano-Sterling C, Iriepa I, Macías MA, Castillo JC, Becerra D.   +4 more
europepmc   +1 more source

Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers

Small Structures, Volume 7, Issue 3, March 2026.
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis, Lauren A. Lowe, Jingyi Yao, Zhenxu Yang, Shaoxue Zeng, Ken‐Tye Yong, Ling Zhu, Yi Shen   +7 more
wiley   +1 more source

REILLY PIPERIDINES [PDF]

Chemical & Engineering News Archive, 1963
openaire   +1 more source

Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M. Merkel, Andrea Hawe   +4 more
wiley   +1 more source

Evaluation of Potentially Inappropriate Medications Prescribed to Older Adults Upon Emergency Department Discharge

Academic Emergency Medicine, Volume 33, Issue 3, March 2026.
ABSTRACT Background Older adults are susceptible to adverse drug effects due to age‐related changes, a higher prevalence of comorbidities, and complexities in medication management. Nearly half of geriatric patients are prescribed at least one new medication at ED discharge.
Jessica Schowe, Andrew M. North, Kyle Schuchter, Katherine M. Hunold, Elizabeth Rozycki   +4 more
wiley   +1 more source

Aryne Generation from Aryl Halides Via Photothermal Red-Light Activation. [PDF]

J Am Chem Soc
Preston-Herrera C, Devin RC, Matter ME, Stache EE.   +3 more
europepmc   +1 more source