Results 271 to 280 of about 84,342 (322)

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Switchable Amination Pathways of Chromones via Iodonium Salt/Amine Modulation. [PDF]

JACS Au
Zhang S, Yang Z, Shi H, Li X, Zhao H, Du Y.   +5 more
europepmc   +1 more source

Acryloyl piperidine/pyrrolidine statistical and block copolymers as hydrate inhibitors: effects of cloud point temperature and copolymer microstructure

Chong Du, Anh Phan, Milan Marić, Phillip Servio   +3 more
openalex   +1 more source

Regulierung der Promiskuitiven Katalyse durch Substratinduzierte Transiente Assemblierung

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
Wir berichten über eine neuartige substratinduzierte transiente Koassemblierung zwischen einem kurzen lysinreichen Peptid und Fmoc‐Gly‐OH. Im aktivierten Zustand zeigt die Assemblierung eine promiskuitive katalytische Aktivität durch die Beschleunigung der Hydrolyse und der C═N‐Kondensationsreaktion.
Ayan Chatterjee, Maximilian Schuler, Marius G. Braun, Christopher V. Synatschke, Qi Lu, Jiyao Yu, David Y. W. Ng, Tanja Weil   +7 more
wiley   +1 more source

Regiodivergent α- and β-Functionalization of Saturated <i>N</i>-Heterocycles by Photocatalytic Oxidation. [PDF]

J Am Chem Soc
Rackl JW, Müller AF, Profyllidou A, Wennemers H.   +3 more
europepmc   +1 more source

Genetische Codierung von Pentafluorphosphato‐Phenylalanin ermöglicht die Herstellung von PF5‐Proteinen als Phosphoprotein‐Mimetika

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
Erweiterung des genetischen Codes mit einem einzigartigen hyperfluorierten Phosphotyrosin‐Analogon. In dieser Arbeit haben wir die nicht‐natürliche Aminosäure Pentafluorphosphato‐Difluormethyl‐Phenylalanin, die sieben Fluoratome und eine permanente negative Ladung trägt, mittels mutierter, orthogonaler Aminoacyl‐tRNA‐Synthetasen erfolgreich in drei ...
Anna Magdalena Ambros, Haocheng Qianzhu, Markus Tiemann, Edan Habel, Katrin Denzinger, Hana Zupan, Matteo Accorsi, Bettina G. Keller, Gerhard Wolber, Thomas Huber, Jörg Rademann   +10 more
wiley   +1 more source

Regulating Promiscuous Catalysis via Substrate‐Induced Transient Assembly

Angewandte Chemie International Edition, Volume 65, Issue 1, 2 January 2026.
We report a novel substrate‐induced transient co‐assembly between a short Lys‐rich peptide and Fmoc‐Gly‐OH. In the activated state, the assembly exhibits promiscuous catalytic activity through the rate enhancements of hydrolysis and C═N condensation reactions.
Ayan Chatterjee, Maximilian Schuler, Marius G. Braun, Christopher V. Synatschke, Qi Lu, Jiyao Yu, David Y.W. Ng, Tanja Weil   +7 more
wiley   +1 more source

Microwave-enhanced additive-free C-H amination of benzoxazoles catalysed by supported copper. [PDF]

Beilstein J Org Chem
Paraschiv A, Maruzzo V, Pettazzi F, Magliocco S, Inaudi P, Brambilla D, Berlier G, Cravotto G, Martina K.   +8 more
europepmc   +1 more source

Genetic Encoding of Pentafluorophosphato‐Phenylalanine Provides PF5‐Proteins as Phosphoprotein Mimetics

Angewandte Chemie International Edition, Volume 65, Issue 1, 2 January 2026.
Genetic code expansion with a unique hyper‐fluorinated phosphotyrosine analog. In this work, we successfully incorporated the unnatural amino acid pentafluorophosphato‐difluoromethyl‐phenylalanine, carrying seven fluorine atoms and a permanent negative charge into three different proteins via the use of mutated orthogonal aminoacyl‐tRNA synthetases ...
Anna Magdalena Ambros, Haocheng Qianzhu, Markus Tiemann, Edan Habel, Katrin Denzinger, Hana Zupan, Matteo Accorsi, Bettina G. Keller, Gerhard Wolber, Thomas Huber, Jörg Rademann   +10 more
wiley   +1 more source

Electronic Activation Enables the Borylation of Alkyl C-H Bonds in Saturated Nitrogen Heterocycles. [PDF]

J Am Chem Soc
D'Angelo KA, Zheng R, Yu IF, Tang MJ, La C, Wetterer RT, Hartwig JF.   +6 more
europepmc   +1 more source