Results 241 to 250 of about 24,581 (324)

Chemoenzymatic Synthesis of Chiral 1-Benzyl-5-(hydroxymethyl)- 2-piperidone Enabled by Lipase AK-Mediated Desymmetrization of Prochiral 1,3-Diol and Its Diacetate [PDF]

, 2016
Gallagher, Timothy, Judeh, Zaher M A, Siri Pamarthy, Varsha, Thinh Khong, Duc   +3 more
core   +1 more source

(4-Oxo-3,4-dihydroquinazolin-3-yl)methyl piperidine-1-carbodithioate

, 2007
Neng-Fang She, Wei Huang
openalex   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.

Chem Soc Rev
Renata H.
europepmc   +1 more source

Lung Adenocarcinoma Expressing an EML4-ALK Fusion Transcript With Premature Stop Codons and Response to Alectinib: A Case Report. [PDF]

Thorac Cancer
Ozaki M, Ikushima H, Suzuki M, Yokoyama A, Fukuda K, Watanabe K, Shinozaki-Ushiku A, Kato M, Ushiku T, Aburatani H, Oda K, Kage H.   +11 more
europepmc   +1 more source

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

The FEBS Journal, EarlyView.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Emergence of PALB2 Reversion Mutations as a Mechanism of Resistance to Niraparib in Breast Cancer: A Case Report. [PDF]

Cancer Sci
Kawamura M, Tada H, Shirota H, Dobashi M, Takenaga N, Yasojima H, Harada-Shoji N, Komine K, Nakamura K, Miyashita M, Kawakami H.   +10 more
europepmc   +1 more source

Design, synthesis, and biological evaluation of novel piperidine-4-carboxamide derivatives as potent CCR5 inhibitors

, 2013
Suwen Hu, Quan Gu, Zhilong Wang, Zhiyong Weng, Yun‐Rui Cai, Xiaowu Dong, Yongzhou Hu, Tao Liu, Xin Xie   +8 more
openalex   +1 more source

Synthetic trap‐peptides identify a TOM complex phosphatase – PP2A dephosphorylates Tom6

The FEBS Journal, EarlyView.
Synthetic trap‐peptides facilitate the identification of complete holoenzymes that bind to the target sequence remarkably close to the phosphorylation site. PP4 bound to, but did not dephosphorylate, the peptide substrate taken from yeast Tom6 pSer16, showing that proximity alone does not induce phosphatase activity.
Laura Scheinost, Christina Ludwig, Nico Höfflin, Asli Aras Taskin, Adinarayana Marada, F.‐Nora Vögtle, Chris Meisinger, Maja Köhn   +7 more
wiley   +1 more source

Stereocontrolled synthesis of 3-hydroxy-2-piperidinone carboxamides by catalytic ring-opening aminolysis of bridged <i>δ</i>-lactam-γ-lactones. [PDF]

RSC Adv
Beng TK, Curry K, Gitonga A, Yu K, Edwards S.   +4 more
europepmc   +1 more source