Results 241 to 250 of about 47,089 (385)

Cycloaddition and Annulation Reactions with Donor‐Acceptor Cyclobutanes

Helvetica Chimica Acta, EarlyView.
Reviewing the rise of donor‐acceptor cyclobutanes in (4 + 2) annulations, from Lewis/Brønsted acid to electrocatalysis, enabling stereoselective access to complex heterocycles and natural products. Abstract Donor‐acceptor (DA) cyclobutanes are emerging as valuable synthetic intermediates due to their ring strain and polarized C─C bonds, which allow for
Emma G. L. Robert, Jerome Waser
wiley   +1 more source

A “One‐Pot” Metal‐Free Synthesis and Evaluation of Antiproliferative Activity of Diversely Functionalized Pyrrolidine‐2‐Ones

Journal of Heterocyclic Chemistry, EarlyView.
A new “one‐pot” metal‐free stereoselective method for the synthesis of novel diversely functionalized pyrrolidine‐2‐ones from N‐alkyl‐ or N‐arylsulfonamidoacetophenones was developed. The majority of obtained compounds possess low micromolar antiproliferative activities.
Samuel Dick, Matija Bekic, David Meuter, Gary Angles, Victoria Sena, Tatiana Timofeeva, Arturo Lopez Villalobos, Liliya V. Frolova   +7 more
wiley   +1 more source

Synthesis of Poly(p‐Terphenyl N,N‐Dimethylpiperidinium)s Using Asymmetric Ketone‐Based Branching Agent

Macromolecular Materials and Engineering, EarlyView.
4‐Biphenylyl trifluoromethyl ketone is used as an asymmetric branching agent in the synthesis of aryl ether‐free poly(p‐terphenyl‐N,N‐dimethylpiperidinium)s via optimized superacid‐catalyzed Friedel‐Crafts polyhydroxyalkylation. The resulting quaternized polymers, with varying branching degrees, show high molecular weights (∼70 kDa) as determined by ...
Ihor Tkachenko, Tetiana Samoilenko, Mariana Gumenna, David Kalabis, Ruslan Kravchuk, Vassili Nazarenko, Iva Matolínová, Valery Shevchenko   +7 more
wiley   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

SnAP-eX Reagents for the Synthesis of Exocyclic 3-Amino- and 3-Alkoxypyrrolidines and Piperidines from Aldehydes.

Organic Letters, 2016
Michael U Luescher, J. Bode
semanticscholar   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Lung Adenocarcinoma Expressing an EML4-ALK Fusion Transcript With Premature Stop Codons and Response to Alectinib: A Case Report. [PDF]

Thorac Cancer
Ozaki M, Ikushima H, Suzuki M, Yokoyama A, Fukuda K, Watanabe K, Shinozaki-Ushiku A, Kato M, Ushiku T, Aburatani H, Oda K, Kage H.   +11 more
europepmc   +1 more source

Lactams. XI. Construction of lactam carbonyl function in 1,3-disubstituted piperidines by mercuric acetate-EDTA oxidation: Effects of carbonyl and related groups at the 3-position.

, 1977
Tozo Fujii, Masashi Ohba, Shigeyuki Yoshifuji   +2 more
openalex   +2 more sources

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, EarlyView.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Anesthetic Management With Remimazolam for Adolescent Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-like Episodes (MELAS): A Case Report. [PDF]

Anesth Prog
Ueda M, Tanaka N, Momota Y, Kawaguchi M.
europepmc   +1 more source