Results 261 to 270 of about 23,915 (334)

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors

ChemistryOpen, EarlyView.
This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A. Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A. A. Ibrahim   +10 more
wiley   +1 more source

Case Report: dose adjustment of orelabrutinib for managing central nervous system post-transplant lymphoproliferative disorder following acute lymphoblastic leukemia transplantation. [PDF]

Front Immunol
Wang W, Chen J, Guan L.
europepmc   +1 more source

A Novel Reductive Amino Cyclization Method and Its Application for the Syntheses of Pyrrolidine and Piperidine Nucleus

, 1986
Masanori Somei, Fumio Yamada, Toshifumi Hasegawa, Masayuki Wakita, Mitsuru Sugiyama   +4 more
openalex   +1 more source

Facile and Practical Synthesis of Substituted Piperidine‐2,6‐Diones Under Transition‐Metal Free Condition

ChemistryOpen, EarlyView.
KOtBu‐promoted facile and practical synthesis of various substituted piperidine‐2,6‐diones between methyl acetates and acrylamides via a Michael addition/intramolecular imidation cascade sequence has been disclosed. And reaction scale‐up, further transformation of representative products, and preparation of bioactive molecules (e. g.
Yue‐Hua Liu, Zhang‐Qin Xue, Kai‐Wen Yang, Hao‐Wen Yin, Bo Yang, Rui Zhang, Hao Zhong, Zhu‐Shuang Bai   +7 more
wiley   +1 more source

Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds. [PDF]

RSC Adv
Tandi M, Sharma V, Gopal B, Sundriyal S.
europepmc   +1 more source

Synthesis of piperidine derivatives with a quinazoline ring system as potential antihypertensive agents.

, 1986
Haruki Takai, H. OBASE, M. TERANISHI, Akira Karasawa, Kazuhiro Kubo, Katsuichi Shuto, Yutaka Kasuya, Koki Shigenobu   +7 more
openalex   +2 more sources

“Molecular Docking and Dynamic Studies of Amide Derivatives from Cinnamic Acid with Potential Anti‐Dengue Virus Activity”

ChemistryOpen, EarlyView.
A library of easily synthesizable CAPE analogs was screened in silico against the dengue virus envelope protein. Compound LQM778 showed stable binding and promising inhibitory potential. This study highlights LQM778 as a candidate for future in vitro validation and structural optimization toward accessible antiviral agents against dengue.
Luis Alfonso Cárdenas‐Granados, Manuel Alejandro Hernández‐Serda, Omar Joel Villegas‐Solís, Víctor Hugo Vázquez‐Valadez, Aldo Yoshio Alarcón‐López, Pablo A. Martínez‐Soriano, Jaqueline Ramos‐Sánchez, Tannya Karen Castro‐Jiménez, José Bustos‐Arriaga, Enrique Angeles   +9 more
wiley   +1 more source

Regioselective α-Phosphonylation of Unprotected Alicyclic Amines. [PDF]

Org Lett
Li B, Yu F, Chen W, Seidel D.
europepmc   +1 more source

Synthesis and biological activity of spiro(isocoumarin-piperidines) and reltaed compounds. I.

, 1981
Masatoshi Yamato, Kuniko Hashigaki, Masao Ikeda, H. OHTAKE, Kenjí Tasaka   +4 more
openalex   +2 more sources

β‐Cyclodextrin Inclusion Complexes with Model Pentapeptides: Role of the Tyrosine Position within the Peptide Chain

ChemistryOpen, EarlyView.
Here, a systematic investigation of the interaction between β‐Cyclodextrin and five model peptides , each constituted by four alanines and one tyrosine differently positioned along the peptide chain, is reported. This integrated approach combines experimental and in‐silico techniques to describe the molecular determinants of interactions and shows how ...
Martina Dragone, Gianluca D’Abrosca, Antonia D’Aniello, Domenico Alberga, Getasew Shitaye, Rinaldo Grazioso, Stefano Tomassi, Luigi Russo, Roberto Fattorusso, Salvatore Di Maro, Giuseppe F. Mangiatordi, Michele Saviano, Gaetano Malgieri, Carla Isernia, Rosa Iacovino   +14 more
wiley   +1 more source