Autoradiography of 3H-pirenzepine and 3H-AFDX-384 in Mouse Brain Regions: Possible Insights into M1, M2, and M4 Muscarinic Receptors Distribution [PDF]
Frontiers in Pharmacology, 2018 Autoradiography helps to determine the distribution and density of muscarinic receptor (MR) binding sites in the brain. However, it relies on the selectivity of radioligands toward their target.
Paulina Valuskova +4 more
doaj +3 more sources
Pirenzepine Binding Sites in the Brain of the Honeybee Apis mellifera: Localization and Involvement in Non-Associative Learning [PDF]
Insects, 2022 Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopolamine,
Chaïma Messikh +2 more
doaj +4 more sources
Effects of Pirenzepine on Pupil Size and Accommodation in Rhesus Monkeys [PDF]
Investigative Opthalmology & Visual Science, 2004 Pirenzepine is suggested to be a relatively selective muscarinic (M(1)) antagonist and is currently under investigation for the treatment of myopia. Atropine, a nonselective M-type antagonist, is used in the treatment of myopia, but has undesired ocular and systemic side effects.
Adrian Glasser +2 more
semanticscholar +4 more sources
DOES PIRENZEPINE DISTINGUISH BETWEEN ‘SUBTYPES’ OF MUSCARINIC RECEPTORS? [PDF]
British Journal of Pharmacology, 1982 Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea‐pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol‐evoked changes in all three organs in a dose‐dependent manner.
Istvan Szelenyi
semanticscholar +5 more sources
British Journal of Anaesthesia, 1998 We conducted a two-part controlled study to evaluate the efficacy of preoperative oral pirenzepine (muscarinic receptor antagonist known to inhibit gastric secretion), ranitidine, and the combination pirenzepine-ranitidine in controlling gastric fluid pH and volume in 210 ASA I children, aged 2-14 yr, undergoing elective surgery.
Kahoru Nishina +4 more
semanticscholar +5 more sources
Unexpected scaffold rearrangement product of pirenzepine found in commercial samples [PDF]
Scientific Reports, 2021 Pharmacovigilance aims at a better understanding of the molecular events triggered by medications to prevent adverse effects, which despite significant advances in our analytical repertoire plague the use of drugs until today. In this study, we find that
Marius Ozenil +10 more
doaj +2 more sources
Effects of Atropine and Pirenzepine on Heart Rate Turbulence [PDF]
Annals of Noninvasive Electrocardiology, 2006 Background: It has been shown that mortality risk in patients after myocardial infarction could be estimated by heart rate turbulence (HRT), a short‐term change in heart rate after ventricular premature beat (VPB), presumably caused by baroreceptor mechanism.
Heinz F. Pitschner +3 more
openaire +4 more sources
Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine [PDF]
Frontiers in Neurology, 2021 HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment.
May Madi Han +5 more
doaj +2 more sources
Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]
J NeurochemIn Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I +14 more
europepmc +2 more sources
Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]
Pigment Cell Melanoma ResSchematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Guo MS +8 more
europepmc +2 more sources