Results 1 to 10 of about 4,218 (200)

Mechanisms of Pilocarpine‐Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle [PDF]

FASEB BioAdvances
Pilocarpine, a muscarinic receptor agonist, is clinically used to reduce intraocular pressure via ciliary muscle contraction. However, the intracellular signaling pathways mediating pilocarpine‐induced nitric oxide (NO) and prostaglandin E2 (PGE2 ...
Giovanna Benozzi, Emmanuel Quinteros Villarruel, Andrés F. Zuluaga, Betina Orman   +3 more
doaj   +3 more sources

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathyResearch in context [PDF]

EBioMedicine
Summary: Background: There is no effective definitive treatment for diabetic peripheral neuropathy (DPN). Strategies that target nerve pathology, limit nerve degeneration, and promote axon regeneration can potentially be beneficial.
Ajith Sivadasan, Paul Fernyhough, Nigel A. Calcutt, Katie E. Frizzi, Kimberly Gardner, Angela Hansen, Ari Breiner, Douglas W. Zochodne, Natalia McInnes, Zubin Punthakee, Sylvie Gosselin, Bruce A. Perkins, Vera Bril   +12 more
doaj   +2 more sources

Pirenzepine exhibits anti-prostate cancer activity and enhances checkpoint inhibitor-based immunotherapy by targeting STING [PDF]

European Journal of Medical Research
Purpose Therapeutic options targeting programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for use in human malignancies, showing clinical benefits.
Jinge Xu, Junyu Li, Junwen Zhang, Yongsheng Yu   +3 more
doaj   +2 more sources

Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala [PDF]

Frontiers in Cellular Neuroscience
The basolateral amygdala (BLA) plays a crucial role in context-specific learning and memory by integrating valence-specific stimuli with internal physiological states.
Todd J. Sahagian, Scott W. Harden, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Charles J. Frazier, Charles J. Frazier   +7 more
doaj   +2 more sources

GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation [PDF]

Scientific Reports
Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development.
Yun He, Qin Ni, Cuiyun Zhang, liulin Zhou, Shuang Li, Yu Tao, Lanhua Liu   +6 more
doaj   +2 more sources

Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis [PDF]

Pharmaceuticals
Pyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis.
Sara Abdalfattah, Caroline Knorz, Akhtar Ayoobi, Ejlal A. Omer, Matteo Rosellini, Max Riedl, Christian Meesters, Thomas Efferth   +7 more
doaj   +2 more sources

Translating Basic Science to Clinical Applications: A Narrative Review of Repurposed Pharmacological Agents in Preclinical Models of Diabetic Neuropathy [PDF]

Biomedicines
Diabetic neuropathy (DN) remains a major clinical burden, characterized by progressive sensory dysfunction, pain, and impaired quality of life. Despite the available symptomatic treatments, there is a pressing need for disease-modifying therapies.
Corina Andrei, Oana Cristina Șeremet, Ciprian Pușcașu, Anca Zanfirescu   +3 more
doaj   +2 more sources

Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses [PDF]

Animals
Gravity may exert species-specific effects on quadrupedal vasoreactivity, reflecting variations in the vertical displacement of the cardiocranial axis from the dorsal plane.
Md. Zahorul Islam, Siyuan Wu, Tomoki Ootawa, Henry Smith, Ha Thi Thanh Nguyen, Etsumori Harada, Atsushi Miyamoto   +6 more
doaj   +2 more sources

Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products [PDF]

BMC Chemistry
In the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges.
Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang   +5 more
doaj   +2 more sources

Adreno-Muscarinic Synergy of Contractile Responses From Human Hyperplastic Prostate [PDF]

International Neurourology Journal
Purpose Adreno-muscarinic synergy, a supra-additional contractile response to simultaneous application of α-adrenoreceptor and muscarinic receptor agonists, is a feature of several lower urinary tract regions that have dual sympathetic and ...
Ben T. Blake-James, Basu Chakrabarty, Christopher H. Fry   +2 more
doaj   +2 more sources