Results 11 to 20 of about 2,792 (196)

Mechanisms of Pilocarpine‐Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle [PDF]

FASEB BioAdvances
Pilocarpine, a muscarinic receptor agonist, is clinically used to reduce intraocular pressure via ciliary muscle contraction. However, the intracellular signaling pathways mediating pilocarpine‐induced nitric oxide (NO) and prostaglandin E2 (PGE2 ...
Giovanna Benozzi, Emmanuel Quinteros Villarruel, Andrés F. Zuluaga, Betina Orman   +3 more
doaj   +3 more sources

Pirenzepine exhibits anti-prostate cancer activity and enhances checkpoint inhibitor-based immunotherapy by targeting STING [PDF]

European Journal of Medical Research
Purpose Therapeutic options targeting programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for use in human malignancies, showing clinical benefits.
Jinge Xu, Junyu Li, Junwen Zhang, Yongsheng Yu   +3 more
doaj   +4 more sources

Unexpected scaffold rearrangement product of pirenzepine found in commercial samples [PDF]

Scientific Reports, 2021
Pharmacovigilance aims at a better understanding of the molecular events triggered by medications to prevent adverse effects, which despite significant advances in our analytical repertoire plague the use of drugs until today. In this study, we find that
Marius Ozenil, Lukas Skos, Alexander Roller, Natalie Gajic, Wolfgang Holzer, Helmut Spreitzer, Sonja Platzer-Ozenil, Chrysoula Vraka, Marcus Hacker, Wolfgang Wadsak, Verena Pichler   +10 more
doaj   +2 more sources

Pirenzepine Binding Sites in the Brain of the Honeybee Apis mellifera: Localization and Involvement in Non-Associative Learning [PDF]

Insects, 2022
Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopolamine,
Chaïma Messikh, Monique Gauthier, Catherine Armengaud   +2 more
doaj   +2 more sources

Autoradiography of 3H-pirenzepine and 3H-AFDX-384 in Mouse Brain Regions: Possible Insights into M1, M2, and M4 Muscarinic Receptors Distribution [PDF]

Frontiers in Pharmacology, 2018
Autoradiography helps to determine the distribution and density of muscarinic receptor (MR) binding sites in the brain. However, it relies on the selectivity of radioligands toward their target.
Paulina Valuskova, Vladimir Farar, Sandor Forczek, Iva Krizova, Jaromir Myslivecek   +4 more
doaj   +2 more sources

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathyResearch in context [PDF]

EBioMedicine
Summary: Background: There is no effective definitive treatment for diabetic peripheral neuropathy (DPN). Strategies that target nerve pathology, limit nerve degeneration, and promote axon regeneration can potentially be beneficial.
Ajith Sivadasan, Paul Fernyhough, Nigel A. Calcutt, Katie E. Frizzi, Kimberly Gardner, Angela Hansen, Ari Breiner, Douglas W. Zochodne, Natalia McInnes, Zubin Punthakee, Sylvie Gosselin, Bruce A. Perkins, Vera Bril   +12 more
doaj   +2 more sources

Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala [PDF]

Frontiers in Cellular Neuroscience
The basolateral amygdala (BLA) plays a crucial role in context-specific learning and memory by integrating valence-specific stimuli with internal physiological states.
Todd J. Sahagian, Scott W. Harden, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Charles J. Frazier, Charles J. Frazier   +7 more
doaj   +2 more sources

GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation [PDF]

Scientific Reports
Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development.
Yun He, Qin Ni, Cuiyun Zhang, liulin Zhou, Shuang Li, Yu Tao, Lanhua Liu   +6 more
doaj   +2 more sources

Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis [PDF]

Pharmaceuticals
Pyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis.
Sara Abdalfattah, Caroline Knorz, Akhtar Ayoobi, Ejlal A. Omer, Matteo Rosellini, Max Riedl, Christian Meesters, Thomas Efferth   +7 more
doaj   +2 more sources

Translating Basic Science to Clinical Applications: A Narrative Review of Repurposed Pharmacological Agents in Preclinical Models of Diabetic Neuropathy [PDF]

Biomedicines
Diabetic neuropathy (DN) remains a major clinical burden, characterized by progressive sensory dysfunction, pain, and impaired quality of life. Despite the available symptomatic treatments, there is a pressing need for disease-modifying therapies.
Corina Andrei, Oana Cristina Șeremet, Ciprian Pușcașu, Anca Zanfirescu   +3 more
doaj   +2 more sources