DESIGN AND EVALUATION OF MICROSPHERES LOADED WITH PIRENZEPINE
International Journal of Pharmaceutical Sciences and Drug Research, 2018 The current objective of the investigation was to fabricate Pirenzepine loaded microspheres for the treatment of gastritis delivered through oral route. The microspheres were prepared by ionotropic gelation technique using sodium as alginate polymer and calcium chloride as cross-linking agent.
D.V.R.N. Bhikshapathi +2 more
openaire +4 more sources
Pirenzepine Promotes the Dimerization of Muscarinic M1 Receptors through a Three-step Binding Process [PDF]
Journal of Biological Chemistry, 2009 Ligand binding to G protein-coupled receptors is a complex process that involves sequential receptor conformational changes, ligand translocation, and possibly ligand-induced receptor oligomerization.
Brigitte Ilien +8 more
openalex +2 more sources
Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis [PDF]
PharmaceuticalsPyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis.
Sara Abdalfattah +7 more
doaj +2 more sources
Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans [PDF]
International Journal of Peptides, 2013 The Japanese herbal medicine (Kampo) Ninjinto has been used for the treatment of gastroenteritis, esogastritis, gastric atony, gastrectasis, vomiting, and anorexia.
Yuhki Sato +4 more
openalex +2 more sources
Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses [PDF]
AnimalsGravity may exert species-specific effects on quadrupedal vasoreactivity, reflecting variations in the vertical displacement of the cardiocranial axis from the dorsal plane.
Md. Zahorul Islam +6 more
doaj +2 more sources
Traditional Chinese medicine could play an important role in diabetes management: Commentary on "National Chinese medicine guideline for the prevention and treatment of diabetes in primary care (2022)". [PDF]
J DiabetesJournal of Diabetes, Volume 16, Issue 4, April 2024.
Jia L +10 more
europepmc +2 more sources
Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products [PDF]
BMC ChemistryIn the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges.
Xiaomin Huang +5 more
doaj +2 more sources
Ethanolic Extracts of Cupressaceae Species Conifers Provide Rapid Protection against Barium Chloride-Induced Cardiac Arrhythmia [PDF]
PharmaceuticalsSudden cardiac death (SCD) is responsible for a high percentage of cardiovascular fatalities, with ventricular arrhythmias being the most common cause.
Meng-Ting Zeng +4 more
doaj +2 more sources
Adreno-Muscarinic Synergy of Contractile Responses From Human Hyperplastic Prostate [PDF]
International Neurourology JournalPurpose Adreno-muscarinic synergy, a supra-additional contractile response to simultaneous application of α-adrenoreceptor and muscarinic receptor agonists, is a feature of several lower urinary tract regions that have dual sympathetic and ...
Ben T. Blake-James +2 more
doaj +2 more sources
Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons [PDF]
Molecular MetabolismObjective: Antagonism of the muscarinic acetylcholine type 1 receptor (M1R) promotes sensory axon repair and is protective in peripheral neuropathy, however, the mechanism remains elusive.
Sanjana Chauhan +6 more
doaj +2 more sources