Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses [PDF]
AnimalsGravity may exert species-specific effects on quadrupedal vasoreactivity, reflecting variations in the vertical displacement of the cardiocranial axis from the dorsal plane.
Md. Zahorul Islam +6 more
doaj +2 more sources
Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products [PDF]
BMC ChemistryIn the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges.
Xiaomin Huang +5 more
doaj +2 more sources
Ethanolic Extracts of Cupressaceae Species Conifers Provide Rapid Protection against Barium Chloride-Induced Cardiac Arrhythmia [PDF]
PharmaceuticalsSudden cardiac death (SCD) is responsible for a high percentage of cardiovascular fatalities, with ventricular arrhythmias being the most common cause.
Meng-Ting Zeng +4 more
doaj +2 more sources
Identification of M1 muscarinic receptors in pulmonary sympathetic nerves in the guinea‐pig by use of pirenzepine [PDF]
British Journal of Pharmacology, 1989 J. Maclagan, A. Fryer, D. Faulkner
semanticscholar +2 more sources
Adreno-Muscarinic Synergy of Contractile Responses From Human Hyperplastic Prostate [PDF]
International Neurourology JournalPurpose Adreno-muscarinic synergy, a supra-additional contractile response to simultaneous application of α-adrenoreceptor and muscarinic receptor agonists, is a feature of several lower urinary tract regions that have dual sympathetic and ...
Ben T. Blake-James +2 more
doaj +2 more sources
DOES PIRENZEPINE DISTINGUISH BETWEEN ‘SUBTYPES’ OF MUSCARINIC RECEPTORS? [PDF]
British Journal of Pharmacology, 1982 I. Szelenyi
semanticscholar +2 more sources
A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 1999 Objective: The gastrointestinal diseases, specially peptic ulcer, are among the most common diseases, and a large number of investigations have been carried out about etiology, prevention and treatment of these diseases.
A Arzi, M Khalili
doaj +1 more source
Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons [PDF]
Molecular MetabolismObjective: Antagonism of the muscarinic acetylcholine type 1 receptor (M1R) promotes sensory axon repair and is protective in peripheral neuropathy, however, the mechanism remains elusive.
Sanjana Chauhan +6 more
doaj +2 more sources
Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]
Pigment Cell Melanoma ResSchematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Guo MS +8 more
europepmc +2 more sources
Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]
J NeurochemIn Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I +14 more
europepmc +2 more sources