Results 11 to 20 of about 4,218 (200)

Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]

Pigment Cell Melanoma Res
Schematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Guo MS, Wu Q, Xia Y, Wu J, Wang X, Yuen GKW, Dong TT, Gao J, Tsim KWK.   +8 more
europepmc   +2 more sources

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]

J Neurochem
In Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I, Muramatsu I, Uwada J, Tsuda Y, Tokunaga A, Irie A, Maeda H, Madokoro Y, Sato T, Uchida Y, Saito T, Saido TC, Sada K, Masuoka T, Matsukawa N.   +14 more
europepmc   +2 more sources

Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

Frontiers in Neurology, 2021
HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment.
May Madi Han, Katie E. Frizzi, Ronald J. Ellis, Ronald J. Ellis, Nigel A. Calcutt, Jerel Adam Fields   +5 more
doaj   +1 more source

Pirenzepine Binding Sites in the Brain of the Honeybee Apis mellifera: Localization and Involvement in Non-Associative Learning

Insects, 2022
Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopolamine,
Chaïma Messikh, Monique Gauthier, Catherine Armengaud   +2 more
doaj   +1 more source

Unexpected scaffold rearrangement product of pirenzepine found in commercial samples

Scientific Reports, 2021
Pharmacovigilance aims at a better understanding of the molecular events triggered by medications to prevent adverse effects, which despite significant advances in our analytical repertoire plague the use of drugs until today. In this study, we find that
Marius Ozenil, Lukas Skos, Alexander Roller, Natalie Gajic, Wolfgang Holzer, Helmut Spreitzer, Sonja Platzer-Ozenil, Chrysoula Vraka, Marcus Hacker, Wolfgang Wadsak, Verena Pichler   +10 more
doaj   +1 more source

A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation [PDF]

, 2004
An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing.
Alvarado, Juan Carlos, Delgado García, José María, Escudero González, Miguel, Márquez Ruiz, Javier, Navarro López, Juan de Dios, Yajeya, Javier   +5 more
core   +4 more sources

Rational Design in Photopharmacology with Molecular Photoswitches

Angewandte Chemie, Volume 135, Issue 30, July 24, 2023., 2023
The state of the art of rational design in photopharmacology is analyzed with a focus on E‐Z molecular photoswitches and on computer‐aided approaches. By meticulously examining the design strategies of photopharmacology through the lens of medicinal chemistry, this review identifies existing trends and novel opportunities for the development of ...
Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski, Ben L. Feringa   +3 more
wiley   +2 more sources

Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases

Scientific Reports, 2022
Organophosphorus (OP) compounds that inhibit acetylcholinesterase are a common cause of poisoning worldwide, resulting in several hundred thousand deaths each year.
Oksana A. Lenina, Konstantin A. Petrov
doaj   +1 more source

Vagus nerve stimulation‐induced stromal cell‐derived factor‐l alpha participates in angiogenesis and repair of infarcted hearts

ESC Heart Failure, Volume 10, Issue 6, Page 3311-3329, December 2023., 2023
Abstract Aims We aim to explore the role and mechanism of vagus nerve stimulation (VNS) in coronary endothelial cells and angiogenesis in infarcted hearts. Methods and results Seven days after rat myocardial infarction (MI) was prepared by ligation of the left anterior descending coronary artery, the left cervical vagus nerve was treated with ...
Yan Wang, Yun Liu, Xing‐yuan Li, Lu‐yuan Yao, MagdaleenaNaemi Mbadhi, Shao‐Juan Chen, Yan‐xia Lv, Xin Bao, Long Chen, Shi‐You Chen, Jing‐xuan Zhang, Yan Wu, Jing Lv, Liu‐liu Shi, Jun‐ming Tang   +14 more
wiley   +1 more source

Clozapine for the treatment of aggressiveness and agitation in advanced dementia

Psychogeriatrics, Volume 23, Issue 6, Page 963-972, November 2023., 2023
Abstract Background Distressing behavioural symptoms, particularly agitation and aggressiveness, remain a difficult problem in everyday clinical practice in the treatment of multimorbid patients with dementia. Clozapine may be an effective therapeutic alternative in this context.
Arwed E. Michael, Nikolaus Michael, Andreas Erfurth, Milenko Kujovic   +3 more
wiley   +1 more source