GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation [PDF]
Scientific ReportsIntrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development.
Yun He +6 more
doaj +2 more sources
Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis [PDF]
PharmaceuticalsPyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis.
Sara Abdalfattah +7 more
doaj +2 more sources
Translating Basic Science to Clinical Applications: A Narrative Review of Repurposed Pharmacological Agents in Preclinical Models of Diabetic Neuropathy [PDF]
BiomedicinesDiabetic neuropathy (DN) remains a major clinical burden, characterized by progressive sensory dysfunction, pain, and impaired quality of life. Despite the available symptomatic treatments, there is a pressing need for disease-modifying therapies.
Corina Andrei +3 more
doaj +2 more sources
Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses [PDF]
AnimalsGravity may exert species-specific effects on quadrupedal vasoreactivity, reflecting variations in the vertical displacement of the cardiocranial axis from the dorsal plane.
Md. Zahorul Islam +6 more
doaj +2 more sources
Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products [PDF]
BMC ChemistryIn the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges.
Xiaomin Huang +5 more
doaj +2 more sources
A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 1999 Objective: The gastrointestinal diseases, specially peptic ulcer, are among the most common diseases, and a large number of investigations have been carried out about etiology, prevention and treatment of these diseases.
A Arzi, M Khalili
doaj +1 more source
Adreno-Muscarinic Synergy of Contractile Responses From Human Hyperplastic Prostate [PDF]
International Neurourology JournalPurpose Adreno-muscarinic synergy, a supra-additional contractile response to simultaneous application of α-adrenoreceptor and muscarinic receptor agonists, is a feature of several lower urinary tract regions that have dual sympathetic and ...
Ben T. Blake-James +2 more
doaj +2 more sources
Insects, 2022 Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopolamine,
Chaïma Messikh +2 more
doaj +1 more source
A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation [PDF]
, 2004 An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing.
Alvarado, Juan Carlos +5 more
core +4 more sources
Rational Design in Photopharmacology with Molecular Photoswitches
Angewandte Chemie, Volume 135, Issue 30, July 24, 2023., 2023 The state of the art of rational design in photopharmacology is analyzed with a focus on E‐Z molecular photoswitches and on computer‐aided approaches. By meticulously examining the design strategies of photopharmacology through the lens of medicinal chemistry, this review identifies existing trends and novel opportunities for the development of ...
Piermichele Kobauri +3 more
wiley +2 more sources