Results 41 to 50 of about 5,284 (226)

Gastric acid suppressants and cognitive decline in people with or without cognitive impairment

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 8, Issue 1, 2022., 2022
Abstract Introduction Studies suggest associations between proton pump inhibitors (PPIs) and dementia risk; however, many neither considered histamine‐2 receptor antagonists (H2RAs) nor baseline cognitive status. Methods Participants (National Alzheimer's Coordinating Center Database; 2005–2021) using a PPI or H2RA were compared. Covariate‐adjusted Cox
Che‐Yuan Wu, Lisa Y. Xiong, Michael Ouk, Jennifer S. Rabin, Nathan Herrmann, Krista L. Lanctôt, Moira K. Kapral, Marcus Law, Hugo Cogo‐Moreira, Jodi D. Edwards, Walter Swardfager   +10 more
wiley   +1 more source

A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

Frontiers in Cellular Neuroscience, 2022
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP ...
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier   +4 more
doaj   +1 more source

Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine [PDF]

Journal of Medicinal Chemistry, 1991
The M1-selective muscarinic receptor antagonist pirenzepine 6H-pyrido[2,3-b][1,4]benzodiazepin-6-one) was derivatized to explore points of attachment of functionalized side chains for the synthesis of receptor probes and ligands for affinity chromatography.
Kenneth A. Jacobson, Barton James Bradbury, Jesse Baumgold, Yishai Karton, Robert Paek   +4 more
openaire   +3 more sources

Methods of preventing and retarding the progression of myopia

Journal of Education, Health and Sport, 2019
Myopia is an increasing problem worldwide. Its prevalence is predicted to over 4 billion of people in 2050, what would be almost 50% of the population.
Ewa Grudzińska, Anna Fabian-Danielewska, Magdalena Gibka   +2 more
doaj   +3 more sources

Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling

Asian Journal of Andrology, 2018
The autonomic nervous system contributes to prostate cancer proliferation and metastasis. However, the exact molecular mechanism remains unclear. In this study, muscarinic acetylcholine receptor M1 (CHRM1) expression was measured via immunohistochemical ...
Qing-Qing Yin, Lin-Hui Xu, Mi Zhang, Chen Xu   +3 more
doaj   +1 more source

The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia

Journal of Pharmacological Sciences, 2015
The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH).
Tomonori Yamanishi, Kanya Kaga, Miki Fuse, Chiharu Shibata, Takao Kamai, Tomoyuki Uchiyama   +5 more
doaj   +1 more source

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

Advances in Pharmacological Sciences, 2009
In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve ...
Anders T. Ryberg, Ondrej Soukup, Gunnar Tobin   +2 more
doaj   +1 more source

Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

BMC Neuroscience, 2012
Background Cholinergic transmission has been implicated in learning, memory and cognition. However, the cellular effects induced by muscarinic acetylcholine receptors (mAChRs) activation are poorly understood in the neocortex. We investigated the effects
Gigout Sylvain, Jones Gareth A, Wierschke Stephan, Davies Ceri H, Watson Jeannette M, Deisz Rudolf A   +5 more
doaj   +1 more source

Are we doing enough for the patient with myopia? A literature review

British and Irish Orthoptic Journal, 2011
Aim:  Myopia is one of the most common eye conditions and often has a progressive nature. With higher degrees come greater risks of visual disability; however, typically no treatment is offered clinically to tackle myopic progression. This review aims to
Marina Parker, Anna R. O’connor
doaj   +1 more source

Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond

Parasitology
Human alveolar echinococcosis is a hard-to-treat and largely untreated parasitic disease with high associated health care costs. The current antiparasitic treatment for alveolar echinococcosis relies exclusively on albendazole, which does not act ...
Weisi Wang, Jun Li, Wenjing Qi, Ying Chen, Mengxiao Tian, Chuanchuan Wu, Yao Zhang, Yingfang Yu, Shuai Han, Xiumin Han, Liping Duan, Wenbao Zhang   +11 more
doaj   +1 more source