Results 41 to 50 of about 5,364 (186)

A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

Frontiers in Cellular Neuroscience, 2022
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP ...
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier   +4 more
doaj   +1 more source

Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity toward the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogues.

Journal of Medicinal Chemistry, 1987
W. Eberlein, G. Trummlitz, W. Engel, G. Schmidt, H. Pelzer, N. Mayer   +5 more
semanticscholar   +2 more sources

The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343–Induced Antinociceptive Effects During Thermal Stimulation of Mice

Journal of Pharmacological Sciences, 2008
The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious ...
Kenji Honda, Keigo Horikawa, Suguru Ando, Kohei Koga, Satoshi Kawata, Keisuke Migita, Yukio Takano   +6 more
doaj   +1 more source

The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia

Journal of Pharmacological Sciences, 2015
The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH).
Tomonori Yamanishi, Kanya Kaga, Miki Fuse, Chiharu Shibata, Takao Kamai, Tomoyuki Uchiyama   +5 more
doaj   +1 more source

Methods of preventing and retarding the progression of myopia

Journal of Education, Health and Sport, 2019
Myopia is an increasing problem worldwide. Its prevalence is predicted to over 4 billion of people in 2050, what would be almost 50% of the population.
Ewa Grudzińska, Anna Fabian-Danielewska, Magdalena Gibka   +2 more
doaj   +3 more sources

Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

BMC Neuroscience, 2012
Background Cholinergic transmission has been implicated in learning, memory and cognition. However, the cellular effects induced by muscarinic acetylcholine receptors (mAChRs) activation are poorly understood in the neocortex. We investigated the effects
Gigout Sylvain, Jones Gareth A, Wierschke Stephan, Davies Ceri H, Watson Jeannette M, Deisz Rudolf A   +5 more
doaj   +1 more source

Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond

Parasitology
Human alveolar echinococcosis is a hard-to-treat and largely untreated parasitic disease with high associated health care costs. The current antiparasitic treatment for alveolar echinococcosis relies exclusively on albendazole, which does not act ...
Weisi Wang, Jun Li, Wenjing Qi, Ying Chen, Mengxiao Tian, Chuanchuan Wu, Yao Zhang, Yingfang Yu, Shuai Han, Xiumin Han, Liping Duan, Wenbao Zhang   +11 more
doaj   +1 more source

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

Advances in Pharmacological Sciences, 2009
In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve ...
Anders T. Ryberg, Ondrej Soukup, Gunnar Tobin   +2 more
doaj   +1 more source

Are we doing enough for the patient with myopia? A literature review

British and Irish Orthoptic Journal, 2011
Aim:  Myopia is one of the most common eye conditions and often has a progressive nature. With higher degrees come greater risks of visual disability; however, typically no treatment is offered clinically to tackle myopic progression. This review aims to
Marina Parker, Anna R. O’connor
doaj   +1 more source

Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

Frontiers in Neuroscience, 2018
The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse ...
Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough, Paul Fernyhough   +3 more
doaj   +1 more source