Results 91 to 100 of about 496,447 (247)

Molecular signatures of neural connectivity in the olfactory cortex

Nature Communications, 2016
The piriform cortex projects to multiple brain regions involved in diverse aspects of olfactory behavior but information about the organization of these outputs is lacking.
Assunta Diodato, Marion Ruinart de Brimont, Yeong Shin Yim, Nicolas Derian, Sandrine Perrin, Juliette Pouch, David Klatzmann, Sonia Garel, Gloria B Choi, Alexander Fleischmann   +9 more
doaj   +1 more source

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC, Gribble, FM, Holt, MK, Reimann, F, Richards, JE, Trapp, S   +5 more
core   +2 more sources

Longitudinal MRI Characterization of T1 and T2 Relaxation Times in an Amyloid Mouse Model of Alzheimer's Disease at 11.7 T

NMR in Biomedicine, Volume 39, Issue 1, January 2026.
In this study, we systematically characterized the longitudinal evolution of T1 and T2 relaxation times at the early to middle stage of Tg2576 mouse model representing the amyloidosis subtype of Alzheimer’s disease. We found that rates of change in relaxation times within the thalamus, hypothalamus, and piriform cortex may serve as markers for ...
Soven Kumar, Xiuli Yang, Yuguo Li, Adnan Bibic, Zhiliang Wei   +4 more
wiley   +1 more source

Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. [PDF]

, 1998
In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local ...
Baram, TZ, Fernandes, MJ, Motte, J, Nehlig, A   +3 more
core   +2 more sources

Recent Advancements in the Research of the Mechanism by Which PPAR‐γ Is Involved in Postoperative Neurocognitive Disorder

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
PPAR‐γ plays a crucial role in the pathogenic mechanisms and regulation of PND. Its pathways are intricately intertwined with inflammatory responses, oxidative stress, β‐amyloid deposition, and abnormal phosphorylation of Tau protein. ABSTRACT Perioperative neurocognitive disorders (PND) have emerged as prevalent central nervous system complications ...
Yubing Huang, Yuhang Zhu, Zhaoqiong Zhu
wiley   +1 more source

In the Piriform Cortex, the Primary Impetus for Information Encoding through Synaptic Plasticity Is Provided by Descending Rather than Ascending Olfactory Inputs

Cerebral Cortex, 2018
Information encoding by means of persistent changes in synaptic strength supports long-term information storage and memory in structures such as the hippocampus.
Christina Strauch, D. Manahan‐Vaughan
semanticscholar   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices

IBRO Reports, 2019
In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control.
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +7 more
doaj   +1 more source

Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]

, 2016
The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni, Dallérac, Glenn, Davies, Heather A., Doyère, Valérie, Kraev, Igor V., Stewart, Michael G.   +5 more
core   +1 more source

Single Inhalation of Peppermint Essential Oil Alleviates Acute Restraint Stress‐Exacerbated Itch in Oxazolone‐Induced Mild Dermatitis: Correlations With Brain Neuronal Activity in Female BALB/c Mouse

Brain and Behavior, Volume 15, Issue 11, November 2025.
Acute restraint stress increased the total duration of scratching behavior in mice regardless of whether dermatitis is present. The number of c‐Fos‐positive cells correlated with pruritic responses. Inhalation of peppermint essential oil alleviated OXA‐induced pruritus under stress conditions and increased the number of c‐Fos‐positive cells in the itch‐
Shotaro Shoji, Yusuke Murata, Hikari Ikeda, Reika Sakai, Yuka Chijiiwa, Masayoshi Mori, Munechika Enjoji   +6 more
wiley   +1 more source