Functionalization of gauzes with liposomes entrapping an anti-inflammatory drug: a strategy to improve wound healing [PDF]
, 2013 From ancientness, suitable materials have been developed to cover the wounds in order to prevent infections and promote proper wound healing. In this study, the successful development of functionalized nonwoven gauzes with liposomes entrapping anti ...
Ferreira, Helena +5 more
core +1 more source
A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands
ChemMedChem, EarlyView.A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova +15 more
wiley +1 more source
Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers [PDF]
BioImpacts, 2014 Introduction: The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion formulations with different carriers including crospovidone, microcrystalline ...
Mohammad Barzegar-jalali +5 more
doaj +1 more source
Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]
, 2003 The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
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Preventing crystal agglomeration of pharmaceutical crystals using temperature cycling and a novel membrane crystallization procedure for seed crystal generation [PDF]
, 2018 In this work, a novel membrane crystallization system was used to cr ystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition.
Nagy, ZK +3 more
core +3 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source
Piroxicam-β-cyclodextrin: a GI safer piroxicam.
Current medicinal chemistry, 2013 Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such
openaire +2 more sources
The Development of Transdermal Piroxicam Using HPMC Matrices With PVP K-30 as a Penetration Enhancer [PDF]
, 2006 The physicochemical properties such as solubility, partition coefficient, and membrane permeability of a drug are required for formulating and estimating drugs absorption that pass through biological membranes.
Aryani, Ni Luh Dewi
core
Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease
Journal of Periodontology, EarlyView.Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar +11 more
wiley +1 more source
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Are Associated with a High Incidence of Gastrointestinal Side-Effects [PDF]
, 2013 Inhibition of the cyclooxygenase (COX) enzyme is the basis for both the efficacy and toxicity of NSAIDs. The aim of this study was to avaluate the non-steroidal anti-inflammatory drugs were used in neuro polyclinic hospital of Dr.
Azizah, L. (Lailan)
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