Results 41 to 50 of about 17,674 (187)

Kristalne modifikacije i profil oslobađanja piroksikama [PDF]

, 2011
Piroxicam is a nonsteroidal anti-inflammatory drug with low aqueous solubility which exhibits polymorphism. The present study was carried out to develop polymorphs of piroxicam with enhanced solubility and dissolution rate by the crystal modification ...
A. Rajendarn, Adhiyaman Rajendran, D. Horter, F. Vrecer, F. Vrečer, Gorajana Adinarayana, Huan Sze, K. Srinivasan, Kamal Dua, Lim Lyn, M. El-Baldry, M. Fernandez, M. Martinez-Oharriz, M. Mihalić, N. Blagden, P. Myrdal, S. Byrn, S. Verheyen, Sanjay Garg, V. Tantishaiyakul   +19 more
core   +2 more sources

Consistency and clarity of pharmacogenomic guidance in UK medicine patient information leaflets: A cross‐sectional analysis

British Journal of Clinical Pharmacology, EarlyView.
Pharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and patient information leaflets (PILs) for all UK‐approved medicines with strong evidence supporting a PGx ...
Parth Narlawar, Chloe Ratcliffe, Videha Sharma, William G. Newman, Munir Pirmohamed, John McDermott   +5 more
wiley   +1 more source

Photocatalyzed Ring Expansion of α‐Ketosulfonylaziridines: Ready Access to δ‐Sultams

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A novel radical–polar crossover (RPC) photoredox‐catalyzed reaction for the synthesis of δ‐sultams from N‐sulfonyl α‐ketoaziridines through a controlled ring opening–expansion process is presented. This method allows the easy access to sultams with an unprecedented substitution pattern in up to 85% yield and 2:1 d.r., and highlights the potential of ...
Marco M. Mastandrea, Stefania Perulli, Vittoria Martini, Ludovica Primitivo, Lei‐Jie Zhou, Christian Mück‐Lichtenfeld, Miquel A. Pericàs, Olga García Mancheño   +7 more
wiley   +2 more sources

Preventing crystal agglomeration of pharmaceutical crystals using temperature cycling and a novel membrane crystallization procedure for seed crystal generation [PDF]

, 2018
In this work, a novel membrane crystallization system was used to cr ystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition.
Nagy, ZK, Othman, R, Simone, E, Vladisavljević, GT   +3 more
core   +3 more sources

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers [PDF]

BioImpacts, 2014
Introduction: The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion formulations with different carriers including crospovidone, microcrystalline ...
Mohammad Barzegar-jalali, Saeed Ghanbarzadeh, Khosro Adibkia, Hadi Valizadeh, Ghobad Mohammadi, Mohammadreza Siahi-Shadbad   +5 more
doaj   +1 more source

Piroxicam-β-cyclodextrin: a GI safer piroxicam.

Current medicinal chemistry, 2013
Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such
openaire   +2 more sources

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

Dermatological Adverse Events Associated With Lapatinib Treatment in Dogs With Urothelial Carcinoma: A Retrospective Study

Veterinary Dermatology, EarlyView.
Lapatinib is widely used in human oncology; however, dermatological adverse events (DAEs) are common and have been correlated with treatment efficacy. In veterinary medicine, lapatinib use in combination with piroxicam has been shown to be effective in treating canine urothelial carcinoma (UC); however, the incidence and prognostic significance of DAEs
Kosuke Horita, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda   +3 more
wiley   +1 more source

Functionalization of gauzes with liposomes entrapping an anti-inflammatory drug: a strategy to improve wound healing [PDF]

, 2013
From ancientness, suitable materials have been developed to cover the wounds in order to prevent infections and promote proper wound healing. In this study, the successful development of functionalized nonwoven gauzes with liposomes entrapping anti ...
Ferreira, Helena, Gomes, A. C., Matamá, Maria Teresa, Paulo, Artur Cavaco, Silva, Carla Manuela Pereira Marinho da, Silva, Raquel   +5 more
core   +1 more source