Results 101 to 110 of about 1,197 (187)

Comparative efficacy of new wake-promoting agents for narcolepsy-a network meta-analysis

BMC Neurology
Background As a rare sleep disorder, narcolepsy is treated with various therapeutic options. This article systematically analyzes the efficacy and safety of novel approved wake-promoting drugs.
Zian Yan, Jiwei Li, Yixin Yu, Shenghan Qiu, Bing Wang, Jiyou Tang   +5 more
doaj   +1 more source

Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Excessive Daytime Sleepiness in Narcolepsy: A Network Meta-Analysis

Nature and Science of Sleep, 2023
Shuqin Zhan,1 Hui Ye,2 Ning Li,1 Yimeng Zhang,1 Yueyang Cheng,1 Yuanqing Wang,1,3 Shimin Hu,1 Yue Hou1 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 2Ignis Therapeutics (Shanghai ...
Zhan S, Ye H, Li N, Zhang Y, Cheng Y, Wang Y, Hu S, Hou Y   +7 more
doaj  

First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H₃R Ligands with Antioxidant Properties

Antioxidants
Neurodegenerative diseases are a major public health problem due to the aging population and multifaceted pathology; therefore, the search for new therapeutic alternatives is of the utmost importance.
Tobias Werner, Tito Añazco, Paula Osses-Mendoza, Alejandro Castro-Álvarez, Cristian O. Salas, Raquel Bridi, Holger Stark, Christian Espinosa-Bustos   +7 more
doaj   +1 more source

Comorbidity of obstructive sleep apnea and narcolepsy: A challenging diagnosis and complex management

Sleep Medicine: X
Introduction: Narcolepsy and obstructive sleep apnea syndrome (OSA) are relevant causes of excessive daytime sleepiness (EDS); although different for etiopathogenesis and symptoms, differential diagnosis is sometimes difficult, and guidelines are lacking
Silvia Miano, Leila Kheirandish-Gozal, Marco De Pieri   +2 more
doaj   +1 more source

Anticonvulsant and procognitive properties of Novel Histamine H3 Receptor Antagonists in male adult rats [PDF]

, 2016
To determine the potential of histamine H3 receptor (H3R) ligands as new antiepileptic and procognitive drugs, aromatic ether derivatives (1-12) belonging to the nonimidazole class of ligands, with high in-vitro binding affinity at human H3R, were tested
Saad, Ali Kassem
core   +1 more source

Histamine H₃ Receptor Isoforms: Insights from Alternative Splicing to Functional Complexity

Biomolecules
Alternative splicing significantly enhances the diversity of the G protein-coupled receptor (GPCR) family, including the histamine H3 receptor (H3R).
Meichun Gao, Jasper F. Ooms, Rob Leurs, Henry F. Vischer   +3 more
doaj   +1 more source

REM sleep in narcolepsy [PDF]

Narcolepsy is mainly associated with excessive daytime sleepiness, but the characteristic feature is abnormal rapid eye movement (REM) sleep phenomena.
Dauvilliers, Yves, Siegel, Jerome M, Thorpy, Michael J   +2 more
core   +1 more source

Wpływ objawów i leczenia narkolepsji na życie seksualne - aktualne dowody i doniesienia naukowe [PDF]

Introduction: Narcolepsy (NT) can manifest as excessive daytime sleepiness (EDS), cataplexy, hypnagogic (HHG) and hypnopompic (HHP) hallucinations, sleep paralysis, orgasmolepsy – all of which may affect patients\u27 functioning. The aim of the study was
Dyzma-Kasprzak, Agnieszka, Dyzma-Kasprzak, Agnieszka, Kasprzak, Karol, Kasprzak, Karol, Pukaluk-Lewinska, Agnieszka, Pukaluk-Lewinska, Agnieszka, Wingralek, Zuzanna, Wingralek, Zuzanna   +7 more
core   +2 more sources

The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice

Scientific Reports
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition characterized by repetitive behaviors, impaired sociability, and persistent neuroinflammation.
Malak Hajar, Petrilla Jayaprakash, Holger Stark, Bassem Sadek   +3 more
doaj   +1 more source

A Review of Current and Future Pharmacologic Treatments for Narcolepsy

European Psychiatry
Introduction Narcolepsy is a rare but disabling neurological disorder involving disruption of the sleep-wake cycle that is often under- or misdiagnosed (Barateau L, et al. J Sleep Res. 2022;31(4):e13631).
P. Chue, J. Chue, M. Tate, A. Andreiev, A. Abba-Aji   +4 more
doaj   +1 more source