Results 111 to 120 of about 574,474 (315)

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Meningitis as the presenting symptom of pituitary adenomata [PDF]

, 1973
R G Lascelles, K K Bhalla, Sarah Tuck, Paul S Graves   +3 more
openalex   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki   +15 more
wiley   +1 more source

A Functional Thyrotropin- and Growth Hormone-Secreting Pituitary Adenoma with a Ultrastructurally Monomorphic Feature: A Case Study.

, 1998
Yukako Ozawa, Toru Kameya, Akira Kasuga, Heiji Naritaka, Naoko Kanda, Hiroshi Maruyama, Takao Saruta   +6 more
openalex   +2 more sources

Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Binge eating disorder (BED) is maintained by increased food‐related incentive salience, which is reflected by an attentional bias for food. Oxytocin acutely attenuates this bias in patients with anorexia nervosa and reduces food intake in males with normal or increased body weight.
Julia Nannt, Mechteld M. van den Hoek Ostende, Brunna Tuschen‐Caffier, Markus Heinrichs, Daniel Sippel, Manfred Hallschmid, Jennifer Svaldi   +6 more
wiley   +1 more source

Tumoral MGMT content predicts survival in patients with aggressive pituitary tumors and pituitary carcinomas given treatment with temozolomide

, 2018
Daniel Bengtsson, Henrik Daa Schrøder, Katarina Berinder, Dominique Maiter, Charlotte Høybye, Óskar Ragnarsson, Ulla Feldt‐Rasmussen, Å.K. Rasmussen, Aart van der Lely, Maria Petersson, Gudmundur Johannsson, Marianne Andersen, Pia Burman   +12 more
openalex   +2 more sources

Preliminary Evidence of the Association Between Binge Eating and Preeclampsia in Pregnant U.S. Military Active‐Duty Service Women

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objectives Binge eating is the most common disordered eating behavior among pregnant women. This study examined the association of binge‐eating frequency with the presence of a self‐reported current preeclampsia diagnosis in a sample of U.S. military active‐duty Service women. Methods Active‐duty Service women (N = 134), 20–27 weeks gestation,
Ruby Schrag, Jason M. Lavender, Autumn Mains, Stephanie Rioux, Isabel Thorstad, Zoe Sinkford, Victoria Thomas, David A. Klein, Mark Haigney, Marian Tanofsky‐Kraff, Katherine A. Thompson   +10 more
wiley   +1 more source

Inhibitory neuron links the causal relationship from air pollution to psychiatric disorders: a large multi-omics analysis

Journal of Big Data
Psychiatric disorders are severe health challenges that exert a heavy public burden. Air pollution has been widely reported as related to psychiatric disorder risk, but their casual association and pathological mechanism remained unclear.
Xisong Liang, Jie Wen, Chunrun Qu, Nan Zhang, Ziyu Dai, Hao Zhang, Peng Luo, Ming Meng, Zhixiong Liu, Fan Fan, Quan Cheng   +10 more
doaj   +1 more source

Outcome Comparison in Microscopic and Endoscopic Trans-Sphenoidal Pituitary Adenoma Surgery in Terms of Extent of Resection [PDF]

Bert-Ram Sah
openalex   +1 more source